The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Follow the leader: the use of leader peptides to guide natural product biosynthesis
Open accessAbstract
The avalanche of genomic information in the past decade has revealed that natural product biosynthesis using the ribosomal machinery is much more widespread than originally anticipated. Nearly all of these compounds are crafted through posttranslational modifications of a larger precursor peptide that often contains the marching orders for the biosynthetic enzymes. We review here the available information for how the peptide sequences in the precursors govern the posttranslational tailoring processes for several classes of natural products. In addition, we highlight the great potential these leader peptide directed biosynthetic systems offer for engineering conformationally restrained and pharmacophore-rich products with structural diversity that greatly expands the proteinogenic repertoire.
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Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501424102 · Cited by 567
Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians
Donia, M. S., Hathaway, B. J., Sudek, S., Haygood, M. G., Rosovitz, M. J., Ravel, J., & Schmidt, E. W. (2006) · Nature Chemical Biology · doi:10.1038/nchembio829 · Cited by 261
Cited by
Cyanobactins—ribosomal cyclic peptides produced by cyanobacteria
Sivonen, K., Leikoski, N., Fewer, D. P., & Jokela, J. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2482-x · Cited by 275
Acker, M. G., Bowers, A. A., & Walsh, C. T. (2009) · Journal of the American Chemical Society · doi:10.1021/ja908777t · Cited by 91
Bottromycins - biosynthesis, synthesis and activity
Franz, L., Kazmaier, U., Truman, A. W., & Koehnke, J. (2021) · Natural Product Reports · doi:10.1039/d0np00097c · Cited by 62
Nguyen, D. T., Zhu, L., Gray, D. L., Woods, T. J., Padhi, C., Flatt, K. M., Mitchell, D. A., & van der Donk, W. A. (2024) · ACS Central Science · doi:10.1021/acscentsci.4c00088 · Cited by 51
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Metadata
- Authors
- Oman, T. J., & van der Donk, W. A.
- Venue
- Nature Chemical Biology
- Published
- 2009-12-16
- Volume
- 6
- Issue
- 1
- Pages
- 9-18
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2054136420
- Cited by
- 408
- References
- 2
- FWCI
- 19.85
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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