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Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
Open accessAbstract
Nanoparticle-based drug delivery systems have been developed to improve the efficacy and reduce the systemic toxicity of a wide range of drugs. Although clinically approved nanoparticles have consistently shown value in reducing drug toxicity, their use has not always translated into improved clinical outcomes. This has led to the development of “multifunctional” nanoparticles, where additional capabilities like targeting and image contrast enhancement are added to the nanoparticles. However, additional functionality means additional synthetic steps and costs, more convoluted behavior and effects in vivo, and also greater regulatory hurdles. The trade-off between additional functionality and complexity is the subject of ongoing debate and the focus of this Review.
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Cancer nanomedicine: progress, challenges and opportunities
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Self-citationDrug delivery systems for RNA therapeutics
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Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer
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Metadata
- Authors
- Cheng, Z., Al Zaki, A., Hui, J. Z., Muzykantov, V. R., & Tsourkas, A.
- Venue
- Science
- Published
- 2012-11-16
- Volume
- 338
- Issue
- 6109
- Pages
- 903-910
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026250154
- Cited by
- 1,322
- References
- 8
- FWCI
- 47.26
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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