The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescence Nanoscopy
Open accessAbstract
Switching on HIV: Newly assembled human immunodeficiency virus (HIV) virions bud from the host cell as immature particles. Proteolysis of the Gag protein, which forms a structural lattice below the viral membrane, leads to the formation of mature infectious HIV. Fusion of mature HIV virions with a target cell is mediated by viral envelope (Env) proteins that occur in trimeric “spikes” on the surface of the virion. Chojnacki et al. (p. 524 ) used subdiffraction microscopy to show that the spikes were dispersed on the immature virion but clustered into a single focus on the mature virion. The clustering was important for infectivity. Coupling Gag proteolysis with clustering may ensure that only particles whose interior has switched to the entry mode are competent for membrane fusion.
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Cited by
Fluorescence nanoscopy in cell biology
Sahl, S. J., Hell, S. W., & Jakobs, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.71 · Cited by 990
Self-citationVisualizing and discovering cellular structures with super-resolution microscopy
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HIV-1 assembly, release and maturation
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Retroviral proteases and their roles in virion maturation
Konvalinka, J., Kräusslich, H.-G., & Müller, B. (2015) · Virology · doi:10.1016/j.virol.2015.03.021 · Cited by 148
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Metadata
- Authors
- Chojnacki, J., Staudt, T., Glass, B., Bingen, P., Engelhardt, J., Anders, M., Schneider, J., Müller, B., Hell, S. W., & Kräusslich, H.-G.
- Venue
- Science
- Published
- 2012-10-26
- Volume
- 338
- Issue
- 6106
- Pages
- 524-528
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971421092
- Cited by
- 283
- References
- 30
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Chojnacki, J., Staudt, T., Glass, B., Bingen, P., Engelhardt, J., Anders, M., Schneider, J., Müller, B., Hell, S. W., & Kräusslich, H.-G. (2012). Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescence Nanoscopy. Science. https://doi.org/10.1126/science.1226359
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