Identity and function of a large gene network underlying mutagenic repair of DNA breaks

Al Mamun, Abu Amar M.; Lombardo, Mary-Jane; Shee, Chandan; Lisewski, Andreas M.; Gonzalez, Caleb; Lin, Dongxu; Nehring, Ralf B.; Saint-Ruf, Claude; Gibson, Janet L.; Frisch, Ryan L.; Lichtarge, Olivier; Hastings, P. J.; Rosenberg, Susan M.

doi:10.1126/science.1226683

Cited by 224Bacterial Genetics and BiotechnologyDNA Repair MechanismsFungal and yeast genetics research

Identity and function of a large gene network underlying mutagenic repair of DNA breaks

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Al Mamun, Abu Amar M., Lombardo, Mary-Jane, Shee, Chandan, Lisewski, Andreas M., Gonzalez, Caleb, Lin, Dongxu, Nehring, Ralf B., Saint-Ruf, Claude +5 more·2012·Science

DOI 10.1126/science.1226683PMC PMC3782309

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Abstract

Mechanisms of DNA repair and mutagenesis are defined on the basis of relatively few proteins acting on DNA, yet the identities and functions of all proteins required are unknown. Here, we identify the network that underlies mutagenic repair of DNA breaks in stressed Escherichia coli and define functions for much of it. Using a comprehensive screen, we identified a network of ≥93 genes that function in mutation. Most operate upstream of activation of three required stress responses (RpoS, RpoE, and SOS, key network hubs), apparently sensing stress. The results reveal how a network integrates mutagenic repair into the biology of the cell, show specific pathways of environmental sensing, demonstrate the centrality of stress responses, and imply that these responses are attractive as potential drug targets for blocking the evolution of pathogens.

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Research on carbon-starved E. coli populations has shown that stress responses are required for the mutagenic repair of DNA breaks.
“Research on carbon-starved E. coli populations has shown that stress responses are required for the mutagenic repair of DNA breaks [75].”
From DNA Data Storage. (2023) · cites this paper as [75]
These data support previous work showing that increases in the mutation rate following DNA damage are due to the action of specific repair machinery, rather than the DNA damage itself.
“These data support previous work showing that increases in the mutation rate following DNA damage are due to the action of specific repair machinery, rather than the DNA damage itself (57–60).”
From Staphylococcus aureus Adapts to Oxidative Stress by Producing H 2 O 2 -Resistant Small-Colony Variants via the SOS Response (2015) · cites this paper as [57]

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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.
Datsenko, K., & Wanner, B. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.120163297 · Cited by 15,902 · see citing works
Escherichia coli and Salmonella :cellular and molecular biology
Neidhardt, F. C. (1996) · ASM Press eBooks · Cited by 8,197 · see citing works
The complete genome sequence of Escherichia coli K-12.
Blattner, F., Plunkett, G., Bloch, C., Perna, N., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C., Mayhew, G., et al. (1997) · Science · doi:10.1126/science.277.5331.1453 · Cited by 7,996 · see citing works
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858 · see citing works
Stochastic Gene Expression in a Single Cell
Elowitz, M. B., Levine, A. J., Siggia, E. D., & Swain, P. S. (2002) · Science · doi:10.1126/science.1070919 · Cited by 5,441 · see citing works
A short course in bacterial genetics
Miller, J. H. (1992) · Cited by 4,391 · see citing works
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored
Szklarczyk, D., Franceschini, A., Kuhn, M., Simonovic, M., Roth, A. C., Mínguez, P., Doerks, T., Stark, M., Muller, J., Bork, P., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq973 · Cited by 3,469 · see citing works
Integration of biological networks and gene expression data using Cytoscape
Cline, M. S., Smoot, M., Cerami, E., Kuchinsky, A., Landys, N., Workman, C., Christmas, R., Avila-Campilo, I., Creech, M., Gross, B., et al. (2007) · Nature Protocols · doi:10.1038/nprot.2007.324 · Cited by 2,507 · see citing works
Mutational Processes Molding the Genomes of 21 Breast Cancers
Nik-Zainal, S., Alexandrov, L. B., Wedge, D. C., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.024 · Cited by 1,909 · see citing works
Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria
Postma, P. W., Lengeler, J. W., & Jacobson, G. R. (1993) · Microbiological Reviews · doi:10.1128/mr.57.3.543-594.1993 · Cited by 1,802 · see citing works
Identification of a protein required for disulfide bond formation in vivo.
Bardwell, J., McGovern, K., & Beckwith, J. (1991) · Cell · doi:10.1016/0092-8674(91)90532-4 · Cited by 961 · see citing works
The RpoS-Mediated General Stress Response in Escherichia coli
Battesti, A., Majdalani, N., & Gottesman, S. (2010) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102946 · Cited by 922 · see citing works
TRANSCRIPTIONAL REGULATION BY cAMP AND ITS RECEPTOR PROTEIN
Kolb, A., Busby, S. J. W., BUC, H. C., Garges, S., & Adhya, S. L. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.003533 · Cited by 848 · see citing works
The groES and groEL heat shock gene products of Escherichia coli are essential for bacterial growth at all temperatures
Fayet, O., Ziegelhoffer, T., & Georgopoulos, C. P. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.3.1379-1385.1989 · Cited by 705 · see citing works
Mutation as a Stress Response and the Regulation of Evolvability
Galhardo, R. S., Hastings, P. J., & Rosenberg, S. M. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701648502 · Cited by 643 · see citing works
Escherichia coli K-12: a cooperatively developed annotation snapshot--2005
Riley, M. A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj405 · Cited by 609 · see citing works
Genes acrA and acrB encode a stress‐induced efflux system of Escherichia coli
Ma, D., Cook, D. N., Alberti, M., Pon, N. G., Nikaido, H., & Hearst, J. E. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02390.x · Cited by 602 · see citing works
Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance
Cirz, R. T., Chin, J. K., Andes, D. R., de Crécy‐Lagard, V., Craig, W. A., & Romesberg, F. E. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030176 · Cited by 576 · see citing works
Adaptive reversion of a frameshift mutation in Escherichia coli.
Cairns, J., & Foster, P. L. (1991) · Genetics · doi:10.1093/genetics/128.4.695 · Cited by 491 · see citing works
The ZnuABC high‐affinity zinc uptake system and its regulator Zur in Escherichia coli
Patzer, S. I., & Hantke, K. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00883.x · Cited by 490 · see citing works
arcA (dye), a global regulatory gene in Escherichia coli mediating repression of enzymes in aerobic pathways.
Iuchi, S., & Lin, E. C. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.6.1888 · Cited by 424 · see citing works
The bacterial enzyme RppH triggers messenger RNA degradation by 5′ pyrophosphate removal
Deana, A., Čelešnik, H., & Belasco, J. G. (2008) · Nature · doi:10.1038/nature06475 · Cited by 418 · see citing works
Evolving responsively: adaptive mutation
Rosenberg, S. M. (2001) · Nature Reviews Genetics · doi:10.1038/35080556 · Cited by 417 · see citing works
[7] Uses of transposons with emphasis on Tn10
Kleckner, N. E., Bender, J., & Gottesman, S. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)04009-d · Cited by 412 · see citing works
Hfq structure, function and ligand binding
Brennan, R. G., & Link, T. M. (2007) · Current Opinion in Microbiology · doi:10.1016/j.mib.2007.03.015 · Cited by 411 · see citing works
Identification of the CRP regulon using in vitro and in vivo transcriptional profiling
Zheng, D. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh908 · Cited by 410 · see citing works
Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions
Roberts, S. A., Sterling, J. F., Thompson, C., Harris, S. F., Mav, D., Shah, R., Klimczak, L. J., Kryukov, G. V., Malc, E. P., Mieczkowski, P. A., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.03.030 · Cited by 405 · see citing works
The Bacterial Twin-Arginine Translocation Pathway
Lee, P. A., Tullman‐Ercek, D., & Georgiou, G. (2006) · Annual Review of Microbiology · doi:10.1146/annurev.micro.60.080805.142212 · Cited by 348 · see citing works
rpoE, the gene encoding the second heat‐shock sigma factor, sigma E, in Escherichia coli.
Rouvière, P. E., Peñas, A. D. L., Mecsas, J. C., Lu, C. Z., Rudd, K. E., & Gross, C. A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07084.x · Cited by 310 · see citing works
SOS Mutator DNA Polymerase IV Functions in Adaptive Mutation and Not Adaptive Amplification
McKenzie, G. J., Lee, P. L., Lombardo, M.-J., Hastings, P. J., & Rosenberg, S. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00204-0 · Cited by 305 · see citing works
The SOS response regulates adaptive mutation
McKenzie, G. J., Harris, R. S., Lee, P. L., & Rosenberg, S. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120161797 · Cited by 295 · see citing works
Self-citation
Isolation and Characterization of the Proton-translocating NADH:ubiquinone Oxidoreductase from Escherichia coli
Leif, H., Sled, V. D., Ohnishi, T., Weiss, H., & Friedrich, T. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0538h.x · Cited by 293 · see citing works
Analysis of cell size and DNA content in exponentially growing and stationary-phase batch cultures of Escherichia coli
Åkerlund, T., Nordström, K. J. V., & Bernander, R. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.23.6791-6797.1995 · Cited by 291 · see citing works
The RssB response regulator directly targets ςS for degradation by ClpXPPreprint
Zhou, Y., Gottesman, S., Hoskins, J. R., Maurizi, M. R., & Wickner, S. (2001) · Genes & Development · doi:10.1101/gad.864401 · Cited by 290 · see citing works
Ubiquinone biosynthesis in microorganisms
Meganathan, R. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10831.x · Cited by 285 · see citing works
DNA synthesis errors associated with double-strand-break repair.
Strathern, J. N., Shafer, B. K., & McGill, C. B. (1995) · Genetics · doi:10.1093/genetics/140.3.965 · Cited by 282 · see citing works
An in vivo pathway for disulfide bond isomerization in Escherichia coli
Rietsch, A., Belin, D., Martin, N., & Beckwith, J. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13048 · Cited by 281 · see citing works
Genome‐wide hypermutation in a subpopulation of stationary‐phase cells underlies recombination‐dependent adaptive mutation
Torkelson, J. D., Harris, R. S., Lombardo, M., Nagendran, J., Thulin, C., & Rosenberg, S. M. (1997) · EMBO Journal · doi:10.1093/emboj/16.11.3303 · Cited by 273 · see citing works
σ S -Dependent Gene Expression at the Onset of Stationary Phase in Escherichia coli : Function of σ S -Dependent Genes and Identification of Their Promoter Sequences
Lacour, S., & Landini, P. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.21.7186-7195.2004 · Cited by 271 · see citing works
Recombination in adaptive mutation.
Harris, R. S., Longerich, S., & Rosenberg, S. (1994) · Science · doi:10.1126/science.8146657 · Cited by 261 · see citing works
Many Microbe Microarrays Database: uniformly normalized Affymetrix compendia with structured experimental metadata
Faith, J. J., Driscoll, M. E., Fusaro, V. A., Cosgrove, E. J., Hayete, B., Juhn, F., Schneider, S. J., & Gardner, T. S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm815 · Cited by 259 · see citing works
A switch from high-fidelity to error-prone DNA double-strand break repair underlies stress-induced mutation
Ponder, R. G., Fonville, N. C., & Rosenberg, S. M. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.025 · Cited by 257 · see citing works
Self-citation
Genetic Analysis of the isc Operon in Escherichia coli Involved in the Biogenesis of Cellular Iron-Sulfur Proteins
Tokumoto, U., & Takahashi, Y. (2001) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a002963 · Cited by 254 · see citing works
BACTERIAL ELECTRON TRANSPORT CHAINS
Anraku, Y. (1988) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.57.070188.000533 · Cited by 247 · see citing works
Linkage of polynucleotides through phosphodiester bonds by an enzyme from Escherichia coli.
Olivera, B. M., & Lehman, I. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.57.5.1426 · Cited by 236 · see citing works
ATP hydrolysis-dependent protease activity of the lon (capR) protein of Escherichia coli K-12.
Charette, M., Henderson, G. W., & Markovitz, A. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.8.4728 · Cited by 235 · see citing works
Adaptation to famine: A family of stationary-phase genes revealed by microarray analysis
Tani, T. H., Khodursky, A. B., Blumenthal, R., Brown, P. O., & Matthews, R. G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212510999 · Cited by 234 · see citing works
Adaptive mutation by deletions in small mononucleotide repeats.
Rosenberg, S. M., Longerich, S., Gee, P., & Harris, R. S. (1994) · Science · doi:10.1126/science.8023163 · Cited by 229 · see citing works
Isolation and Characterization of the Proton-translocating NADH:ubiquinone Oxidoreductase from Escherichia coli
Leif, H., Sled, V. D., Ohnishi, T., et al. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20594.x · Cited by 225 · see citing works
Error‐prone DNA polymerase IV is controlled by the stress‐response sigma factor, RpoS, in Escherichia coli
Layton, J. C., & Foster, P. L. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03704.x · Cited by 206 · see citing works
Spontaneous DNA breakage in single living Escherichia coli cells
Pennington, J. M., & Rosenberg, S. M. (2007) · Nature Genetics · doi:10.1038/ng2051 · Cited by 206 · see citing works
Origin of Mutations Under Selection: The Adaptive Mutation Controversy
Roth, J. R., Kugelberg, E., Reams, A. B., Kofoid, E., & Andersson, D. I. (2006) · Annual Review of Microbiology · doi:10.1146/annurev.micro.60.080805.142045 · Cited by 203 · see citing works
Genetic mapping of katF, a locus that with katE affects the synthesis of a second catalase species in Escherichia coli
Loewen, P. C., & Triggs, B. L. (1984) · Journal of Bacteriology · doi:10.1128/jb.160.2.668-675.1984 · Cited by 201 · see citing works
Adaptive reversion of a frameshift mutation in Escherichia coli by simple base deletions in homopolymeric runs.
Foster, P. L., & Trimarchi, J. M. (1994) · Science · doi:10.1126/science.8023164 · Cited by 197 · see citing works
NAD(P)H:flavin oxidoreductase of Escherichia coli. A ferric iron reductase participating in the generation of the free radical of ribonucleotide reductase.
Fontecave, M., ELIASSON, R., & Reichard, P. A. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45356-2 · Cited by 195 · see citing works
Regulation of RpoS proteolysis in Escherichia coli : The response regulator RssB is a recognition factor that interacts with the turnover element in RpoS
Becker, G., Klauck, E., & Hengge‐Aronis, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6439 · Cited by 192 · see citing works
The NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli
Friedrich, T. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00024-3 · Cited by 192 · see citing works
Insertion of inverted Ter sites into the terminus region of the Escherichia coli chromosome delays completion of DNA replication and disrupts the cell cycle
Sharma, B., & Hill, T. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.mmi_18010045.x · Cited by 192 · see citing works
Regulation of DNA repair in hypoxic cancer cells
Bindra, R. S., Crosby, M. E., & Glazer, P. M. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9061-3 · Cited by 191 · see citing works
arcA(dye),大腸菌において好気経路の酵素を抑える働きをする全体的な制御遺伝子
Iuchi, S., & C, L. E. C. (1988) · Cited by 189 · see citing works
Isolation of catalase-deficient Escherichia coli mutants and genetic mapping of katE, a locus that affects catalase activity
Loewen, P. C. (1984) · Journal of Bacteriology · doi:10.1128/jb.157.2.622-626.1984 · Cited by 184 · see citing works
The role of integration host factor In gene expression in Escherichia coli
Freundlich, M., Ramani, N., Mathew, E., Sirko, A., & Tsui, P. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb01432.x · Cited by 184 · see citing works
A defect in cell wall recycling triggers autolysis during the stationary growth phase of Escherichia coli
Templin, M. F., Ursinus, A., & Höltje, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.15.4108 · Cited by 177 · see citing works
A novel device of bacterial signal transducers.
Ishige, K., Nagasawa, S., Tokishita, S.-I., & Mizuno, T. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06850.x · Cited by 173 · see citing works
Identification of UvrY as the Cognate Response Regulator for the BarA Sensor Kinase in Escherichia coli
Pernestig, A.-K., Melefors, Ö., & Georgellis, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m001550200 · Cited by 173 · see citing works
Regulation by destruction: design of the σE envelope stress response
Ades, S. E. (2008) · Current Opinion in Microbiology · doi:10.1016/j.mib.2008.10.004 · Cited by 173 · see citing works
Adaptive Amplification
Hastings, P. J., Bull, H. J., Klump, J. R., & Rosenberg, S. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00176-8 · Cited by 150 · see citing works
Two Enzymes, Both of Which Process Recombination Intermediates, Have Opposite Effects on Adaptive Mutation in Escherichia coli
Foster, P. L., Trimarchi, J. M., & Maurer, R. (1996) · Genetics · doi:10.1093/genetics/142.1.25 · Cited by 147 · see citing works
Opposing Roles of the Holliday Junction Processing Systems of Escherichia coli in Recombination-Dependent Adaptive Mutation
Harris, R. S., Ross, K. J., & Rosenberg, S. M. (1996) · Genetics · doi:10.1093/genetics/142.3.681 · Cited by 143 · see citing works
Adaptation and Preadaptation of Salmonella enterica to Bile
Hernández, S. B., Cota, I., Ducret, A., Aussel, L., & Casadesús, J. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002459 · Cited by 140 · see citing works
Role of the GlnK signal transduction protein in the regulation of nitrogen assimilation in Escherichia coli
Atkinson, M. R., & Ninfa, A. J. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00932.x · Cited by 139 · see citing works
General Stress Response Regulator RpoS in Adaptive Mutation and Amplification inEscherichia coli
Lombardo, M., Aponyi, I., & Rosenberg, S. M. (2004) · Genetics · doi:10.1534/genetics.166.2.669 · Cited by 136 · see citing works
Sequence‐selective interactions with RNA by CspB, CspC and CspE, members of the CspA family of Escherichia coli
Phadtare, S., & Inouye, M. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01541.x · Cited by 131 · see citing works
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals
Sáenz, Y. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg168 · Cited by 129 · see citing works
Nucleotide sequence and genetic characterization reveal six essential genes for the LIV-I and LS transport systems of Escherichia coli.
Adams, M. D., Wagner, L. M., Graddis, T. J., Landick, R. C., Antonucci, T. K., Gibson, A. L., & Oxender, D. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38417-0 · Cited by 128 · see citing works
Repair of DNA Damage Induced by Bile Salts in Salmonella enterica
Prieto, A. I., Ramos‐Morales, F., & Casadesús, J. (2006) · Genetics · doi:10.1534/genetics.106.060889 · Cited by 126 · see citing works
Growth Phase-Dependent Regulation of the Extracytoplasmic Stress Factor, σ E , by Guanosine 3′,5′-Bispyrophosphate (ppGpp)
Costanzo, A., & Ades, S. E. (2006) · Journal of Bacteriology · doi:10.1128/jb.01981-05 · Cited by 122 · see citing works
Control of the alternative sigma factor σE in Escherichia coli
Ades, S. E. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.02.010 · Cited by 121 · see citing works
Impact of a stress-inducible switch to mutagenic repair of DNA breaks on mutation in Escherichia coli
Shee, C., Gibson, J. L., Darrow, M. C., González, C., & Rosenberg, S. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104681108 · Cited by 120 · see citing works
One-step purification from Escherichia coli of complex II (succinate: ubiquinone oxidoreductase) associated with succinate-reducible cytochrome b556
Kita, K., Vibat, C. R. T., Meinhardt, S., Guest, J. R., & Gennis, R. B. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81666-6 · Cited by 119 · see citing works
From cell membrane to nucleotides: The phosphate regulon in Escherichia coli
Torriani, A. (1990) · BioEssays · doi:10.1002/bies.950120804 · Cited by 118 · see citing works
Stress‐induced mutation via DNA breaks in Escherichia coli: A molecular mechanism with implications for evolution and medicine
Rosenberg, S. M., Shee, C., Frisch, R. L., & Hastings, P. J. (2012) · BioEssays · doi:10.1002/bies.201200050 · Cited by 115 · see citing works
Transient and Heritable Mutators in Adaptive Evolution in the Lab and in Nature
Rosenberg, S. M., Thulin, C., & Harris, R. S. (1998) · Genetics · doi:10.1093/genetics/148.4.1559 · Cited by 114 · see citing works
RpoS-Regulated Genes of Escherichia coli Identified by Random lacZ Fusion Mutagenesis
Vijayakumar, S., Kirchhof, M. G., Patten, C. L., & Schellhorn, H. E. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.24.8499-8507.2004 · Cited by 109 · see citing works
Novel Members of the Cra Regulon Involved in Carbon Metabolism in Escherichia coli
Shimada, T., Yamamoto, K., & Ishihama, A. (2010) · Journal of Bacteriology · doi:10.1128/jb.01214-10 · Cited by 107 · see citing works
H-NS-Dependent Regulation of Flagellar Synthesis Is Mediated by a LysR Family Protein
Ko, M., & Park, C. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.16.4670-4672.2000 · Cited by 105 · see citing works
The Escherichia coli lipB Gene Encodes Lipoyl (Octanoyl)-Acyl Carrier Protein:Protein Transferase
Jordan, S. W., & Cronan, J. E. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.5.1582-1589.2003 · Cited by 101 · see citing works
Hsc66 and Hsc20, a new heat shock cognate molecular chaperone system from Escherichia coli
Vickery, L. E., Silberg, J. J., & Ta, D. T. (1997) · Protein Science · doi:10.1002/pro.5560060511 · Cited by 99 · see citing works
The Two-Component Network and the General Stress Sigma Factor RpoS (σS) in Escherichia coli
Hengge, R. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-78885-2_4 · Cited by 98 · see citing works
The Escherichia coli hemL gene encodes glutamate 1-semialdehyde aminotransferase
Ilag, L. L., Jahn, D., Eggertsson, G., & Söll, D. G. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.11.3408-3413.1991 · Cited by 97 · see citing works
Stress-Induced β-Lactam Antibiotic Resistance Mutation and Sequences of Stationary-Phase Mutations in the Escherichia coli Chromosome
Petrosino, J. F., Galhardo, R. S., Morales, L. D., & Rosenberg, S. M. (2009) · Journal of Bacteriology · doi:10.1128/jb.00732-09 · Cited by 96 · see citing works
The DNA sequence of the sulfate activation locus from Escherichia coli K-12.
Leyh, T. S., Vogt, T., & Suo, Y. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50034-5 · Cited by 94 · see citing works
Multimerization of Phosphorylated and Non-phosphorylated ArcA Is Necessary for the Response Regulator Function of the Arc Two-component Signal Transduction System
Jeon, Y., Lee, Y. S., Han, J. S., Kim, J. B., & Hwang, D. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104855200 · Cited by 90 · see citing works
Lipoic acid metabolism in Escherichia coli: isolation of null mutants defective in lipoic acid biosynthesis, molecular cloning and characterization of the E. coli lip locus, and identification of the lipoylated protein of the glycine cleavage system
Boom, T. J. V., Reed, K. E., & Cronan, J. E. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.20.6411-6420.1991 · Cited by 89 · see citing works
The role of UbiX in Escherichia coli coenzyme Q biosynthesis
Gulmezian, M., Hyman, K., Marbois, B. N., Clarke, C. F., & Javor, G. T. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.08.009 · Cited by 87 · see citing works
Structure and autoregulation of the metJ regulatory gene in Escherichia coli.
Saint‐Girons, I., Duchange, N., Cohen, G. N., & Zakin, M. M. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89890-8 · Cited by 86 · see citing works
Regulation of the Alternative Sigma Factor σ E during Initiation, Adaptation, and Shutoff of the Extracytoplasmic Heat Shock Response in Escherichia coli
Ades, S. E., Grigorova, I., & Gross, C. A. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.8.2512-2519.2003 · Cited by 86 · see citing works
Adaptive Amplification and Point Mutation Are Independent Mechanisms: Evidence for Various Stress-Inducible Mutation Mechanisms
Hastings, P. J., Slack, A., Petrosino, J. F., & Rosenberg, S. M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020399 · Cited by 85 · see citing works
The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation
Caldara, M., Charlier, D., & Cunin, R. (2006) · Microbiology · doi:10.1099/mic.0.29088-0 · Cited by 83 · see citing works
ArgR-Independent Induction and ArgR-Dependent Superinduction of theastCADBEOperon inEscherichia coli
Kiupakis, A. K., & Reitzer, L. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.11.2940-2950.2002 · Cited by 80 · see citing works
The Transcription Elongation Factor NusA Is Required for Stress-Induced Mutagenesis in Escherichia coli
Cohen, S., & Walker, G. C. (2010) · Current Biology · doi:10.1016/j.cub.2009.11.039 · Cited by 79 · see citing works
Probing a Role of Subunit IV of the -type Ubiquinol Oxidase by Deletion and Cross-linking Analyses
Saiki, K., Nakamura, H., Mogi, T., & Anraku, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.26.15336 · Cited by 75 · see citing works
MalI, a novel protein involved in regulation of the maltose system of Escherichia coli, is highly homologous to the repressor proteins GalR, CytR, and LacI
Reidl, J., Römisch, K., Ehrmann, M., & Boos, W. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.9.4888-4899.1989 · Cited by 74 · see citing works
The dinB Operon and Spontaneous Mutation in Escherichia coli
McKenzie, G. J., Magner, D. B., Lee, P. L., & Rosenberg, S. M. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.13.3972-3977.2003 · Cited by 72 · see citing works
Ribokinase from Escherichia coli K12. Nucleotide sequence and overexpression of the rbsK gene and purification of ribokinase.
Hope, J. N., Bell, A. W., Hermodson, M. A., & Groarke, J. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57450-6 · Cited by 70 · see citing works
Decrypting the H-NS-dependent regulatory cascade of acid stress resistance in Escherichia coli
Krin, E., Danchin, A., & Soutourina, O. A. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-273 · Cited by 69 · see citing works
Two Mechanisms Produce Mutation Hotspots at DNA Breaks in Escherichia coli
Shee, C., Gibson, J. L., & Rosenberg, S. M. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.08.033 · Cited by 68 · see citing works
The σE stress response is required for stress‐induced mutation and amplification in Escherichia coli
Gibson, J. L., Lombardo, M., Thornton, P. C., Hu, K. H., Galhardo, R. S., Beadle, B., Habib, A. R., Magner, D. B., Frost, L. S., Herman, C., et al. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07213.x · Cited by 68 · see citing works
Error-Prone DNA Polymerase IV Is Regulated by the Heat Shock Chaperone GroE in Escherichia coli
Layton, J. C., & Foster, P. L. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.2.449-457.2005 · Cited by 58 · see citing works
Induction of the Escherichia coli aidB gene under oxygen-limiting conditions requires a functional rpoS (katF) gene
Volkert, M. R., Hajec, L. I., Matijašević, Z., Fang, F. C., & Prince, R. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.24.7638-7645.1994 · Cited by 54 · see citing works
Separate DNA Pol II- and Pol IV-Dependent Pathways of Stress-Induced Mutation during Double-Strand-Break Repair in Escherichia coli Are Controlled by RpoS
Frisch, R. L., Su, Y., Thornton, P. C., Gibson, J. L., Rosenberg, S. M., & Hastings, P. J. (2010) · Journal of Bacteriology · doi:10.1128/jb.00570-10 · Cited by 51 · see citing works
Conditional-lethal deoxyribonucleic acid ligase mutant of Escherichia coli
Dermody, J. J., Robinson, G., & Sternglanz, R. (1979) · Journal of Bacteriology · doi:10.1128/jb.139.2.701-704.1979 · Cited by 50 · see citing works
Genetic Mapping of Mutations Affecting Phosphoglucose Isomerase and Fructose Diphosphatase in Escherichia coli
Fraenkel, D. G. (1967) · Journal of Bacteriology · doi:10.1128/jb.93.5.1582-1587.1967 · Cited by 50 · see citing works
Cloning and Expression of Aminopeptidase P Gene from Escherichia coli HB101 and Characterization of Expressed Enzyme1
Yoshimoto, T., Murayama, N., Honda, T., Tone, H., & Tsuru, D. (1988) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a122430 · Cited by 48 · see citing works
λ nutR mutations convert HK022 nun protein from a transcription termination factor to a suppressor of termination
Robledo, R., Gottesman, M. E., & Weisberg, R. A. (1990) · Journal of Molecular Biology · doi:10.1016/0022-2836(90)90226-c · Cited by 46 · see citing works
The gene for Escherichia coli diadenosine tetraphosphatase is located immediately clockwise to folA and forms an operon with ksgA
Blanchin-Roland, S., Blanquet, S., Schmitter, J., & Fayat, G. (1986) · Molecular and General Genetics MGG · doi:10.1007/bf00338091 · Cited by 45 · see citing works
Regulatory defects of a conditionally lethal nusAts mutant of Escherichia coli
Nakamura, Y., Mizusawa, S., Court, D. L., & Tsugawa, A. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90384-0 · Cited by 44 · see citing works
Polyphosphate kinase regulates error‐prone replication by DNA polymerase IV in Escherichia coli
Stumpf, J. D., & Foster, P. L. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04724.x · Cited by 44 · see citing works
Roles of E. coli double-strand-break-repair proteins in stress-induced mutation
He, A. S., Rohatgi, P. R., Hersh, M. N., & Rosenberg, S. M. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.10.006 · Cited by 42 · see citing works
Molecular cloning of the Escherichia coli gene for diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Méchulam, Y., Fromant, M., Mellot, P., Plateau, P., Blanchin-Roland, S., Fayat, G., & Blanquet, S. (1985) · Journal of Bacteriology · doi:10.1128/jb.164.1.63-69.1985 · Cited by 41 · see citing works
Isolation and expression of the Escherichia coli gene encoding malate dehydrogenase
Sutherland, P. A., & McAlister-Henn, L. (1985) · Journal of Bacteriology · doi:10.1128/jb.163.3.1074-1079.1985 · Cited by 41 · see citing works
Recombination-dependent mutation in Escherichia coli occurs in stationary phase.
McKenzie, G. J., Lombardo, M., & Rosenberg, S. M. (1998) · Genetics · doi:10.1093/genetics/149.2.1163 · Cited by 39 · see citing works
The role of the trehalose system in regulating the maltose regulon of Escherichia coli
Decker, K., Gerhardt, F., & Boos, W. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01395.x · Cited by 33 · see citing works
Different regions of Mlc and NagC, homologous transcriptional repressors controlling expression of the glucose and N‐acetylglucosamine phosphotransferase systems in Escherichia coli, are required for inducer signal recognition
Pennetier, C., Domínguez‐Ramírez, L., & PLUMBRIDGE, J. A. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.06041.x · Cited by 31 · see citing works
Identification of the Escherichia coli K-12 ybhE Gene as pgl , Encoding 6-Phosphogluconolactonase
Thomason, L. C., Court, D. L., Datta, A. R., Khanna, R., & Rosner, J. L. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.24.8248-8253.2004 · Cited by 30 · see citing works
Different characteristics distinguish early versus late arising adaptive mutations in Escherichia coli FC40
Powell, S., & Wartell, R. M. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(00)00149-4 · Cited by 29 · see citing works
Spermidine biosynthesis in Escherichia coli: promoter and termination regions of the speED operon
Xie, Q. W., Tabor, C. W., & Tabor, H. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.8.4457-4465.1989 · Cited by 27 · see citing works
Purification and characterization of protease Re, a cytoplasmic endoprotease in Escherichia coli
Park, J. H., Lee, Y. S., Chung, C. H., & Goldberg, A. L. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.2.921-926.1988 · Cited by 27 · see citing works
An Escherichia coli membrane protein with a unique signal sequence
Neuwald, A. F., & Stauffer, G. V. (1989) · Gene · doi:10.1016/0378-1119(89)90047-4 · Cited by 17 · see citing works
Mapping of trxB, a mutation responsible for reduced thioredoxin reductase activity
Haller, B. L., & Fuchs, J. A. (1984) · Journal of Bacteriology · doi:10.1128/jb.159.3.1060-1062.1984 · Cited by 15 · see citing works
Stress, genomes, and evolution
Mittelman, D., & Wilson, J. H. (2010) · Cell Stress and Chaperones · doi:10.1007/s12192-010-0205-y · Cited by 14 · see citing works
Direct Transfer of NADH From Malate Dehydrogenase to Complex I in Escherichia coli
Amarneh, B., & Vik, S. B. (2005) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:42:3:251 · Cited by 13 · see citing works
Escherichia coli proline tRNA: Structure and recognition sites for prolyl-tRNA synthetase
Hasegawa, T., & Yokogawa, T. (2000) · Nucleic Acids Symposium Series · doi:10.1093/nass/44.1.7 · Cited by 13 · see citing works
YqiC of Salmonella enterica serovar Typhimurium is a membrane fusogenic protein required for mice colonization
Carrica, M. D. C., Craig, P. O., García-Angulo, V. A., Aguirre, A., Véscovi, E. G., Goldbaum, F. A., & Cravero, S. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-95 · Cited by 10 · see citing works

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Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus
Kraemer, M. U. G., Reiner, R. C., Brady, O. J., Messina, J. P., Gilbert, M., Pigott, D. M., Yi, D., Johnson, K. B., Earl, L., Marczak, L. B., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0376-y · Cited by 1,393 · see citing works
Mechanisms of bacterial persistence during stress and antibiotic exposure
Harms, A., Maisonneuve, E., & Gerdes, K. (2016) · Science · doi:10.1126/science.aaf4268 · Cited by 913 · see citing works
Molecular Mechanisms Underlying Bacterial Persisters
Maisonneuve, E., & Gerdes, K. (2014) · Cell · doi:10.1016/j.cell.2014.02.050 · Cited by 644 · see citing works
Cancer as a metabolic disease: implications for novel therapeutics
Seyfried, T. N., Flores, R. E., Poff, A. M., & D’Agostino, D. P. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt480 · Cited by 479 · see citing works
Microbial Persistence and the Road to Drug Resistance
Cohen, N. R., Lobritz, M. A., & Collins, J. J. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.05.009 · Cited by 459 · see citing works
Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates
Windels, E. M., Michiels, J. E., Fauvart, M., Wenseleers, T., den Bergh, B. V., & Michiels, J. J. (2019) · The ISME Journal · doi:10.1038/s41396-019-0344-9 · Cited by 366 · see citing works
Bacterial persisters: molecular mechanisms and therapeutic development
Niu, H., Gu, J., & Zhang, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01866-5 · Cited by 334 · see citing works
Staying in Shape: the Impact of Cell Shape on Bacterial Survival in Diverse Environments
Yang, D. C., Blair, K. M., & Salama, N. R. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-15 · Cited by 283 · see citing works
Trouble is coming: Signaling pathways that regulate general stress responses in bacteria
Gottesman, S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.005593 · Cited by 253 · see citing works
Heterogeneity in efflux pump expression predisposes antibiotic-resistant cells to mutation
Meouche, I. E., & Dunlop, M. J. (2018) · Science · doi:10.1126/science.aar7981 · Cited by 240 · see citing works
Environmentally responsive genome-wide accumulation of de novo Arabidopsis thaliana mutations and epimutationsPreprint
Jiang, C., Mithani, A., Belfield, E. J., Mott, R., Hurst, L. D., & Harberd, N. P. (2014) · Genome Research · doi:10.1101/gr.177659.114 · Cited by 234 · see citing works
Trade-off Mechanisms Shaping the Diversity of Bacteria
Ferenci, T. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.11.009 · Cited by 220 · see citing works
Emergence of antibiotic resistance from multinucleated bacterial filaments
Bos, J., Zhang, Q., Vyawahare, S., Rogers, E. J., Rosenberg, S. M., & Austin, R. H. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420702111 · Cited by 213 · see citing works
Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic
Barrett, T. C., Mok, W. W. K., Murawski, A. M., & Brynildsen, M. P. (2019) · Nature Communications · doi:10.1038/s41467-019-09058-4 · Cited by 206 · see citing works
Cancer as a mitochondrial metabolic disease
Seyfried, T. N. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00043 · Cited by 202 · see citing works
Gamblers: An Antibiotic-Induced Evolvable Cell Subpopulation Differentiated by Reactive-Oxygen-Induced General Stress Response
Pribis, J. P., Garcı́a-Villada, L., Zhai, Y., Lewin‐Epstein, O., Wang, A. Z., Liu, J., Xia, J., Mei, Q., Fitzgerald, D. M., Bos, J., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.037 · Cited by 173 · see citing works
Metabolic therapy: A new paradigm for managing malignant brain cancer
Seyfried, T. N., Flores, R. E., Poff, A. M., D’Agostino, D. P., & Mukherjee, P. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.07.015 · Cited by 182 · see citing works
Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance
Fitzgerald, D. M., Hastings, P. J., & Rosenberg, S. M. (2016) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-050216-121919 · Cited by 172 · see citing works
Molecular mechanisms and clinical implications of bacterial persistence
Michiels, J. E., den Bergh, B. V., Verstraeten, N., & Michiels, J. J. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.10.002 · Cited by 164 · see citing works
Staphylococcus aureus Adapts to Oxidative Stress by Producing H 2 O 2 -Resistant Small-Colony Variants via the SOS Response
Painter, K. L., Strange, E., Parkhill, J., Bamford, K. B., Armstrong-James, D., & Edwards, A. M. (2015) · Infection and Immunity · doi:10.1128/iai.03016-14 · Cited by 153 · see citing works
Antibiotics: Combatting Tolerance To Stop Resistance
Windels, E. M., Michiels, J. E., den Bergh, B. V., Fauvart, M., & Michiels, J. J. (2019) · mBio · doi:10.1128/mbio.02095-19 · Cited by 158 · see citing works
Multilayered genetic safeguards limit growth of microorganisms to defined environments
Gallagher, R. R., Patel, J. R., Interiano, A. L., Rovner, A. J., & Isaacs, F. J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1378 · Cited by 156 · see citing works
“Metabolic burden” explained: stress symptoms and its related responses induced by (over)expression of (heterologous) proteins in Escherichia coli
Snoeck, S., Guidi, C., & Mey, M. D. (2024) · Microbial Cell Factories · doi:10.1186/s12934-024-02370-9 · Cited by 145 · see citing works
R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli
Wimberly, H., Shee, C., Thornton, P. C., Sivaramakrishnan, P., Rosenberg, S. M., & Hastings, P. J. (2013) · Nature Communications · doi:10.1038/ncomms3115 · Cited by 138 · see citing works
Drug tolerant persister cell plasticity in cancer: a revolutionary strategy for more effective anticancer therapies
He, J., Qiu, Z., Fan, J., Xie, X., Sheng, Q., & Sui, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01891-4 · Cited by 133 · see citing works
sigma S , a major player in the response to environmental stresses in E scherichia coli : role, regulation and mechanisms of promoter recognition
Landini, P., Egli, T. W., Wolf, J., & Lacour, S. (2013) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12112 · Cited by 128 · see citing works
Engineered proteins detect spontaneous DNA breakage in human and bacterial cells
Shee, C., Cox, B. D., Gu, F., Luengas, E. M., Joshi, M. C., Chiu, L.-Y., Magnan, D. R., Halliday, J. A., Frisch, R. L., Gibson, J. L., et al. (2013) · eLife · doi:10.7554/elife.01222 · Cited by 128 · see citing works
Targets for Combating the Evolution of Acquired Antibiotic Resistance
Culyba, M. J., Mo, C. Y., & Kohli, R. M. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00109 · Cited by 125 · see citing works
RpoS and the bacterial general stress response
Bouillet, S., Bauer, T., & Gottesman, S. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00151-22 · Cited by 122 · see citing works
Status of pathogens, antibiotic resistance genes and antibiotic residues in wastewater treatment systems
Nnadozie, C. F., Kumari, S., & Bux, F. (2017) · Reviews in Environmental Science and Bio/Technology · doi:10.1007/s11157-017-9438-x · Cited by 119 · see citing works
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer
Noronha, A., Nataraj, N. B., Lee, J. S., Zhitomirsky, B., Oren, Y., Oster, S. K., Lindzen, M., Mukherjee, S., Will, R. D., Ghosh, S., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0111 · Cited by 110 · see citing works
Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics
Mo, C. Y., Manning, S. A., Roggiani, M., Culyba, M. J., Samuels, A. N., Sniegowski, P., Goulian, M., & Kohli, R. M. (2016) · mSphere · doi:10.1128/msphere.00163-16 · Cited by 98 · see citing works
Accumulation of Deleterious Mutations During Bacterial Range Expansions
Bosshard, L., Dupanloup, I., Tenaillon, O., Bruggmann, R., Ackermann, M., Peischl, S., & Excoffier, L. (2017) · Genetics · doi:10.1534/genetics.117.300144 · Cited by 101 · see citing works
Different tradeoffs result from alternate genetic adaptations to a common environment
Rodríguez‐Verdugo, A., Carrillo-Cisneros, D., González‐González, A., Gaut, B. S., & Bennett, A. F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406886111 · Cited by 100 · see citing works
A shifting mutational landscape in 6 nutritional states: Stress-induced mutagenesis as a series of distinct stress input–mutation output relationships
Maharjan, R. P., & Ferenci, T. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2001477 · Cited by 98 · see citing works
Antimicrobials, Stress and Mutagenesis
Rodríguez-Rojas, A., Makarova, O., & Rolff, J. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004445 · Cited by 96 · see citing works
What is mutation? A chapter in the series: How microbes “jeopardize” the modern synthesis
Fitzgerald, D. M., & Rosenberg, S. M. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007995 · Cited by 91 · see citing works
Antibiotic Resistance via Bacterial Cell Shape-Shifting
Ojkic, N., Serbanescu, D., & Banerjee, S. (2022) · mBio · doi:10.1128/mbio.00659-22 · Cited by 91 · see citing works
Hfq links translation repression to stress-induced mutagenesis in E. coliPreprint
Chen, J., & Gottesman, S. (2017) · Genes & Development · doi:10.1101/gad.302547.117 · Cited by 88 · see citing works
Nucleoid-associated proteins shape chromatin structure and transcriptional regulation across the bacterial kingdom
Amemiya, H. M., Schroeder, J. W., & Freddolino, L. (2021) · Transcription · doi:10.1080/21541264.2021.1973865 · Cited by 85 · see citing works
Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
Lukačišinová, M., Fernando, B., & Bollenbach, T. (2020) · Nature Communications · doi:10.1038/s41467-020-16932-z · Cited by 79 · see citing works
Stress-induced mutagenesis and complex adaptation
Ram, Y., & Hadany, L. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.1025 · Cited by 77 · see citing works
Mutations in Global Regulators Lead to Metabolic Selection during Adaptation to Complex Environments
Saxer, G., Krepps, M. D., Merkley, E. D., Ansong, C. K., Kaiser, B. L. D., Valovska, M.-T., Ristic, N., Yeh, P. T., Prakash, V. P., Leiser, O. P., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004872 · Cited by 78 · see citing works
SOS response and its regulation on the fluoroquinolone resistance.
Qin, T., Kang, H., Ma, P., Li, P.-P., Huang, L., & Gu, B. (2015) · PubMed Central · doi:10.3978/j.issn.2305-5839.2015.12.09 · Cited by 74 · see citing works
Low mutational load and high mutation rate variation in gut commensal bacteria
Ramiro, R. S., Durão, P., Bank, C., & Gordo, I. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000617 · Cited by 68 · see citing works
Escherichia coli Genes and Pathways Involved in Surviving Extreme Exposure to Ionizing Radiation
Byrne, R. T., Chen, S. H., Wood, E. A., Cabot, E. L., & Cox, M. M. (2014) · Journal of Bacteriology · doi:10.1128/jb.01589-14 · Cited by 73 · see citing works
Stress-Induced Mutagenesis, Gambler Cells, and Stealth Targeting Antibiotic-Induced Evolution
Pribis, J. P., Zhai, Y., Hastings, P. J., & Rosenberg, S. M. (2022) · mBio · doi:10.1128/mbio.01074-22 · Cited by 69 · see citing works
Living Organisms Author Their Read-Write Genomes in Evolution
Shapiro, J. A. (2017) · Biology · doi:10.3390/biology6040042 · Cited by 68 · see citing works
Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry
Freddolino, L., Yang, J., Momen-Roknabadi, A., & Tavazoie, S. (2018) · eLife · doi:10.7554/elife.31867 · Cited by 59 · see citing works
Irregularities in genetic variation and mutation rates with environmental stresses
Ferenci, T. (2019) · Environmental Microbiology · doi:10.1111/1462-2920.14822 · Cited by 64 · see citing works
Treatment resistance in urothelial carcinoma: an evolutionary perspective
Vlachostergios, P. J., & Faltas, B. M. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0026-y · Cited by 62 · see citing works
Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity
Ji, X., Zou, J., Peng, H., Stolle, A.-S., Xie, R., Zhang, H., Peng, B., Mekalanos, J. J., & Zheng, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1822026116 · Cited by 63 · see citing works
Combating Evolution to Fight Disease
Rosenberg, S. M., & Queitsch, C. (2014) · Science · doi:10.1126/science.1247472 · Cited by 62 · see citing works
Distinct Mechanisms of Nuclease-Directed DNA-Structure-Induced Genetic Instability in Cancer Genomes
Zhao, J., Wang, G., del Mundo, I. M. A., McKinney, J. A., Lu, X., Bacolla, A., Boulware, S. B., Zhang, C., Zhang, H., Ren, P. Y., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.014 · Cited by 59 · see citing works
Reactive oxygen species accelerate de novo acquisition of antibiotic resistance in E. coli
Qi, W., Jonker, M. J., de Leeuw, W. C., Brul, S., & ter Kuile, B. H. (2023) · iScience · doi:10.1016/j.isci.2023.108373 · Cited by 59 · see citing works
Was low CO2 a driving force of C4 evolution: Arabidopsis responses to long-term low CO2 stress
Li, Y., Xu, J., Haq, N. U., Zhang, H., & Zhu, X. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru193 · Cited by 59 · see citing works
Structural insight into LexA–RecA* interaction
Kovačič, L., Paulič, N., Leonardi, A., Hodnik, V., Anderluh, G., Podlesek, Z., Žgur‐Bertok, D., Križaj, I., & Butala, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt744 · Cited by 58 · see citing works
Adaptive laboratory evolution of Escherichia coli lacking cellular byproduct formation for enhanced acetate utilization through compensatory ATP consumption
Seong, W., Han, G. H., Lim, H. S., Baek, J. I., Kim, S.-J., Kim, D., Kim, S. K., Lee, H., Kim, H., Lee, S., et al. (2020) · Metabolic Engineering · doi:10.1016/j.ymben.2020.09.005 · Cited by 56 · see citing works
Ethanol exposure increases mutation rate through error-prone polymerases
Voordeckers, K., Colding, C., Grasso, L., Pardo, B., Hoes, L., Kominek, J., Gielens, K., Dekoster, K., Gordon, J., van der Zande, E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17447-3 · Cited by 60 · see citing works
The external domains of the HIV-1 envelope are a mutational cold spot
Geller, R., Domingo‐Calap, P., Cuevas, J. M., Rossolillo, P., Negroni, M., & Sanjuán, R. (2015) · Nature Communications · doi:10.1038/ncomms9571 · Cited by 55 · see citing works
Hypermutation in single-stranded DNA
Saini, N., & Gordenin, D. A. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102868 · Cited by 47 · see citing works
Knowns and Unknowns of Vitamin B 6 Metabolism in Escherichia coli
Tramonti, A., Nardella, C., di Salvo, M. L., Barile, A., D’Alessio, F., de Crécy‐Lagard, V., & Contestabile, R. (2021) · EcoSal Plus · doi:10.1128/ecosalplus.esp-0004-2021 · Cited by 51 · see citing works
Multigenerational Exposure to Heat Stress Induces Phenotypic Resilience, and Genetic and Epigenetic Variations in Arabidopsis thaliana Offspring
Yadav, N. S., Titov, V., Ayemere, I., Byeon, B., Ilnytskyy, Y., & Kovalchuk, I. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.728167 · Cited by 51 · see citing works
Ancient genes establish stress-induced mutation as a hallmark of cancer
Cisneros, L. H., Bussey, K. J., Orr, A. J., Miočević, M., Lineweaver, C. H., & Davies, P. C. W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176258 · Cited by 47 · see citing works
Diadenosine tetraphosphate (Ap4A) – an E. coli alarmone or a damage metabolite?
Despotović, D., Brandis, A. S., Savidor, A., Levin, Y., Fumagalli, L., & Tawfik, D. S. (2017) · FEBS Journal · doi:10.1111/febs.14113 · Cited by 48 · see citing works
Multiple Osmotic Stress Responses in Acidihalobacter prosperus Result in Tolerance to Chloride Ions
Dopson, M., Holmes, D. S., Lazcano, M., McCredden, T. J., Bryan, C. G., Mulroney, K. T., Steuart, R. F. L., Jackaman, C., & Watkin, E. L. J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02132 · Cited by 47 · see citing works
Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation
Krin, E., Pierlé, S. A., Sismeiro, O., Jagla, B., Dillies, M., Varet, H., Irazoki, O., Campoy, S., Rouy, Z., Cruveiller, S., et al. (2018) · BMC Genomics · doi:10.1186/s12864-018-4716-8 · Cited by 46 · see citing works
Hypermutability and error catastrophe due to defects in ribonucleotide reductase
Ahluwalia, D., & Schaaper, R. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310849110 · Cited by 43 · see citing works
Mutational Signatures Indicative of Environmental Stress in Bacteria
Maharjan, R. P., & Ferenci, T. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu306 · Cited by 43 · see citing works
Targeting evolution to inhibit antibiotic resistance
Merrikh, H., & Kohli, R. M. (2020) · FEBS Journal · doi:10.1111/febs.15370 · Cited by 43 · see citing works
Adaptive Evolution: How Bacteria and Cancer Cells Survive Stressful Conditions and Drug Treatment
Russo, M., Sogari, A., & Bardelli, A. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1588 · Cited by 42 · see citing works
Live cell imaging of SOS and prophage dynamics in isogenic bacterial populations
Helfrich, S., Pfeifer, E., Krämer, C. E. M., Sachs, C. C., Wiechert, W., Kohlheyer, D., Nöh, K., & Frunzke, J. (2015) · Molecular Microbiology · doi:10.1111/mmi.13147 · Cited by 42 · see citing works
Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase
Xia, J., Chen, L.-T., Mei, Q., Ma, C.-H., Halliday, J. A., Lin, H.-Y., Magnan, D. R., Pribis, J. P., Fitzgerald, D. M., Hamilton, H. M., et al. (2016) · Science Advances · doi:10.1126/sciadv.1601605 · Cited by 44 · see citing works
Antibiotics trigger initiation of SCCmec transfer by inducing SOS responses
Liu, P., Wu, Z., Xue, H., & Zhao, X. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx153 · Cited by 40 · see citing works
Bacteriophage GIL01 gp7 interacts with host LexA repressor to enhance DNA binding and inhibit RecA-mediated auto-cleavage
Fornelos, N., Butala, M., Hodnik, V., Anderluh, G., Bamford, J. K. H., & Salas, M. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv634 · Cited by 40 · see citing works
Establishment of a multi-species biofilm model and metatranscriptomic analysis of biofilm and planktonic cell communities
Nakamura, Y., Yamamoto, N., Kino, Y., Yamamoto, N., Kamei, S., Mori, H., Kurokawa, K., & Nakashima, N. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7532-6 · Cited by 39 · see citing works
Transcriptome-Level Signatures in Gene Expression and Gene Expression Variability during Bacterial Adaptive Evolution
Erickson, K. E., Otoupal, P. B., & Chatterjee, A. (2017) · mSphere · doi:10.1128/msphere.00009-17 · Cited by 40 · see citing works
A fluorescence-based genetic screen reveals diverse mechanisms silencing small RNA signaling in E. coli
Chen, J., To, L., Mets, F. D., Luo, X., Majdalani, N., Tai, C., & Gottesman, S. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2106964118 · Cited by 36 · see citing works
Specificity Determinants for Autoproteolysis of LexA, a Key Regulator of Bacterial SOS Mutagenesis
Mo, C. Y., Birdwell, L. D., & Kohli, R. M. (2014) · Biochemistry · doi:10.1021/bi500026e · Cited by 36 · see citing works
Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli
Moore, J. M., Correa, R., Rosenberg, S. M., & Hastings, P. J. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006733 · Cited by 35 · see citing works
Bacterial phenotypic heterogeneity in DNA repair and mutagenesis
Vincent, M. S., & Uphoff, S. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190364 · Cited by 34 · see citing works
Natural phenolic compounds as biofilm inhibitors of multidrug-resistant Escherichia coli – the role of similar biological processes despite structural diversity
Buchmann, D., Schwabe, M., Weiss, R., Kuss, A. W., Schaufler, K., Schlüter, R., Rödiger, S., Guenther, S., & Schultze, N. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1232039 · Cited by 34 · see citing works
Structures of RNA Complexes with the Escherichia coli RNA Pyrophosphohydrolase RppH Unveil the Basis for Specific 5′-End-dependent mRNA Decay
Vasilyev, N., & Serganov, A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.634824 · Cited by 34 · see citing works
Screen for genes involved in radiation survival of Escherichia coli and construction of a reference database
Sargentini, N. J., Gularte, N. P., & Hudman, D. A. (2016) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2016.10.001 · Cited by 32 · see citing works
Regulation of filamentation by bacteria and its impact on the productivity of compounds in biotechnological processes
Rizzo, M. G., Plano, L. M. D., & Franco, D. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10590-3 · Cited by 31 · see citing works
Elevated Mutagenesis Does Not Explain the Increased Frequency of Antibiotic Resistant Mutants in Starved Aging Colonies
Katz, S., & Hershberg, R. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003968 · Cited by 31 · see citing works
A Network Biology Approach to Decipher Stress Response in Bacteria Using Escherichia coli As a Model
Nagar, S. D., Aggarwal, B., Joon, S., Bhatnagar, R., & Bhatnagar, S. (2016) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2016.0028 · Cited by 30 · see citing works
Heterogeneity of spontaneous DNA replication errors in single isogenic Escherichia coli cells
Woo, A. C., Faure, L., Dapa, T., & Matic, I. (2018) · Science Advances · doi:10.1126/sciadv.aat1608 · Cited by 29 · see citing works
Knowledge integration and decision support for accelerated discovery of antibiotic resistance genes
Youn, J., Rai, N., & Tagkopoulos, I. (2022) · Nature Communications · doi:10.1038/s41467-022-29993-z · Cited by 29 · see citing works
Global transcriptional response of Escherichia coli MG1655 cells exposed to the oxygenated monoterpenes citral and carvacrol
Chueca, B., Pérez-Sáez, E., Pagán, R., & García‐Gonzalo, D. (2017) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2017.06.002 · Cited by 28 · see citing works
ppGpp and RNA-polymerase backtracking guide antibiotic-induced mutable gambler cells
Zhai, Y., Minnick, P. J., Pribis, J. P., Garcı́a-Villada, L., Hastings, P. J., Herman, C., & Rosenberg, S. M. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.03.003 · Cited by 28 · see citing works
Prediction and redesign of protein–protein interactions
Lua, R. C., Marciano, D. C., Katsonis, P., Adikesavan, A. K., Wilkins, A. D., & Lichtarge, O. (2014) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2014.05.004 · Cited by 28 · see citing works
Drugging evolution of antibiotic resistance at a regulatory network hub
Zhai, Y., Pribis, J. P., Dooling, S. W., Garcı́a-Villada, L., Minnick, P. J., Xia, J., Liu, J., Mei, Q., Fitzgerald, D. M., Herman, C., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg0188 · Cited by 26 · see citing works
Trade-offs, trade-ups, and high mutational parallelism underlie microbial adaptation during extreme cycles of feast and famine
Behringer, M. G., Ho, W.-C., Miller, S. F., Worthan, S. B., Cen, Z., Stikeleather, R., & Lynch, M. (2024) · Current Biology · doi:10.1016/j.cub.2024.02.040 · Cited by 25 · see citing works
Mutation and Recombination Rates Vary Across Bacterial Chromosome
Kivisaar, M. (2019) · Microorganisms · doi:10.3390/microorganisms8010025 · Cited by 26 · see citing works
Selection-Driven Accumulation of Suppressor Mutants in Bacillus subtilis: The Apparent High Mutation Frequency of the Cryptic gudB Gene and the Rapid Clonal Expansion of gudB+ Suppressors Are Due to Growth under Selection
Gunka, K., Stannek, L., Care, R. A., & Commichau, F. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066120 · Cited by 24 · see citing works
PortEco: a resource for exploring bacterial biology through high-throughput data and analysis tools
Hu, J. C., Sherlock, G. J., Siegele, D. A., Aleksander, S., Ball, C. A., Demeter, J., Gouni, S., Holland, T. A., Karp, P. D., Lewis, J. E., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1203 · Cited by 24 · see citing works
Gene Expression Variability Underlies Adaptive Resistance in Phenotypically Heterogeneous Bacterial Populations
Erickson, K. E., Otoupal, P. B., & Chatterjee, A. (2015) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5b00095 · Cited by 23 · see citing works
Coordinated Regulation of Rsd and RMF for Simultaneous Hibernation of Transcription Apparatus and Translation Machinery in Stationary-Phase Escherichia coli
Yoshida, H., Wada, A., Shimada, T., Maki, Y., & Ishihama, A. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01153 · Cited by 24 · see citing works
Macrophage adaptation leads to parallel evolution of genetically diverse Escherichia coli small‐colony variants with increased fitness in vivo and antibiotic collateral sensitivity
Ramiro, R. S., Costa, H. N. P., & Gordo, I. (2016) · Evolutionary Applications · doi:10.1111/eva.12397 · Cited by 24 · see citing works

Roles of Nucleoid-Associated Proteins in Stress-Induced Mutagenic Break Repair in StarvingEscherichia coli
Moore, J. M., Magnan, D. R., Mojica, A. K., Núñez, M. A. B., Bates, D. B., Rosenberg, S. M., & Hastings, P. J. (2015) · Genetics · doi:10.1534/genetics.115.178970 · Cited by 22 · see citing works
Impact of a stress-inducible switch to mutagenic repair of DNA breaks on mutation in Escherichia coli
Shee, C., Gibson, J. L., Darrow, M. C., González, C., & Rosenberg, S. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104681108 · Cited by 120 · see citing works
Sewing Up DNA Repair
Riddihough, G. (2012) · Science Signaling · doi:10.1126/scisignal.2003855
Separate DNA Pol II- and Pol IV-Dependent Pathways of Stress-Induced Mutation during Double-Strand-Break Repair in Escherichia coli Are Controlled by RpoS
(2010)
Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress
Shee, C., Hastings, P. J., & Rosenberg, S. M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6280-4_2 · Cited by 2 · see citing works

Authors: Al Mamun, A. A. M., Lombardo, M.-J., Shee, C., Lisewski, A. M., Gonzalez, C., Lin, D., Nehring, R. B., Saint-Ruf, C., Gibson, J. L., Frisch, R. L., Lichtarge, O., Hastings, P. J., & Rosenberg, S. M.
Affiliations: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030–3411, USA.
Baylor College of Medicine (US)
U1001 INSERM, Université Paris, Descartes, Sorbonne Paris cité, site Necker, 156 rue de Vaugirard, 75730 Paris Cedex 15, France.
Corresponding author: Lombardo, Mary-Jane
Shee, Chandan
Rosenberg, Susan M.
ORCID: Lisewski, Andreas M.
Lin, Dongxu
Nehring, Ralf B.
Lichtarge, Olivier
Hastings, P. J.
Rosenberg, Susan M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2012-12-07
Volume: 338
Issue: 6112
Pages: 1344-1348
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1226683
PMC: PMC3782309
OpenAlex: W2048699088
Cited by: 224
References: 133
Citations by year: 2026: 8 · 2025: 9 · 2024: 15 · 2023: 22 · 2022: 10 · 2021: 10 · 2020: 15 · 2019: 17 · 2018: 11 · 2017: 27 · 2016: 22 · 2015: 20 · 2014: 21 · 2013: 17
FWCI: 11.14
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Funders: National Cancer Institute (DP1CA174424)
National Institute of General Medical Sciences (GM66099, F32GM019909, F32-GM19909, R01GM53158, R01GM064022, R25GM056929, R01GM066099, R01GM053158, R01GM079656, F32GM095267, R01-GM64022, GM79656)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: DNA repair, mutagenesis, DNA strand breaks, Escherichia coli, gene networks, RpoS, RpoE, SOS response, stress response, environmental sensing, therapeutic target, pathogen evolution
MeSH terms: Bacterial Proteins, DNA Repair, Escherichia coli, Sigma Factor, SOS Response, Genetics, Stress, Physiological, Gene Expression Regulation, Bacterial, Mutagenesis, Gene Regulatory Networks, DNA Breaks, Double-Stranded

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Identity and function of a large gene network underlying mutagenic repair of DNA breaks

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