The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold
Open accessAbstract
Push Me, Release, Pull You: In eukaryotic cells, nearly all long-distance transport of cargos is carried out by the microtubule-based motors kinesin and dynein. These opposite-polarity motors move cargos bidirectionally so that they reach their cellular destinations with spatial and temporal specificity. To understand transport by motor ensembles, Derr et al. (p. 662 , published online 11 October; see the Persective by Diehl ) used a DNA scaffold for building an artificial cargo that could be programmed to bind different numbers and types of molecular motors with defined geometry. A cargo with multiple copies of the same motor was transported with minimal interference, suggesting that similar-polarity motors can coordinate without the need for additional cellular factors. However, ensembles of opposite-polarity motors frequently engaged in a sort of “tug of war,” which could only be resolved by releasing one motor from the microtubule track. Thus, within the cell, it is likely that regulation is required for bidirectional transport.
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Cites
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Self-citationMICROTUBULE POLYMERIZATION DYNAMICS
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Myosin V Walks Hand-Over-Hand: Single Fluorophore Imaging with 1.5-nm Localization
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Rapid prototyping of 3D DNA-origami shapes with caDNAno
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Self-citationHirokawa, N., Niwa, S., & Tanaka, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.039 · Cited by 1,138
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Self-citationSingle-Molecule Analysis of Dynein Processivity and Stepping Behavior
Reck-Peterson, S. L., Yildiz, A., Carter, A. P., Gennerich, A., Zhang, N., & Vale, R. D. (2006) · Cell · doi:10.1016/j.cell.2006.05.046 · Cited by 635
Self-citationBidirectional transport along microtubules
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Cited by
Seeman, N. C., & Sleiman, H. F. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.68 · Cited by 1,875
Three-Dimensional Structures Self-Assembled from DNA Bricks
Ke, Y., Ong, L. L., Shih, W. M., & Yin, P. (2012) · Science · doi:10.1126/science.1227268 · Cited by 1,246
Self-citationRegulation of microtubule motors by tubulin isotypes and post-translational modifications
Sirajuddin, M., Rice, L. M., & Vale, R. D. (2014) · Nature Cell Biology · doi:10.1038/ncb2920 · Cited by 600
Chemistries for DNA Nanotechnology
Madsen, M., & Gothelf, K. V. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00570 · Cited by 447
Bidirectional cargo transport: moving beyond tug of war
Hancock, W. O. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3853 · Cited by 428
Metadata
- Authors
- Derr, N. D., Goodman, B. S., Jungmann, R., Leschziner, A. E., Shih, W. M., & Reck-Peterson, S. L.
- Venue
- Science
- Published
- 2012-11-02
- Volume
- 338
- Issue
- 6107
- Pages
- 662-665
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963489221
- Cited by
- 433
- References
- 40
- FWCI
- 15.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Derr, N. D., Goodman, B. S., Jungmann, R., Leschziner, A. E., Shih, W. M., & Reck-Peterson, S. L. (2012). Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold. Science. https://doi.org/10.1126/science.1226734
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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