The spatial and temporal origin of chandelier cells in mouse neocortex
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Building Cross Connectivity: Chandelier cells innervate the initial segment of axons from pyramidal neurons and are thus placed to regulate pyramidal cell circuits in the brain. Chandelier cells of mice are marked by expression of the NKX2.1 transcription factor. Taniguchi et al. (p. 70 , published online 22 November) followed the development of these neurons and found that chandelier cells originate from the ventral germinal zone. The nascent cells migrate and integrate with cortical neurons following specific developmental pathways.
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A significant fraction of chandelier cells, typically considered part of the PV group, express PV protein weakly or perhaps not at all.
“Taniguchi et al. (Taniguchi et al., 2013) found that a significant fraction of chandelier cells, interneurons typically considered part of the PV group (see below), express PV protein weakly or perhaps not all.”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Taniguchi et al., 2013
Weakly or non-PV-expressing chandelier cells share the same developmental origin as PV-expressing chandelier cells.
“Weakly or non-PV-expressing chandelier cells have the same developmental origin as those that express the protein”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Taniguchi et al., 2013
In this work as well as in previous works, chandelier interneurons were not identified on the slice preparations.
“In this work as well as in previous works10, 11 chandelier interneurons22 were not identified on the slice preparations.”
From Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin (2015) · cites this paper as [22]
A substantial fraction of mouse chandelier cells does not contain detectable levels of PV.
“A substantial fraction of chandelier cells in the mouse does not contain detectable levels of PV”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Taniguchi et al., 2013
Chandelier cells are particularly abundant at the border between layers 1 and 2 and in layer 6, and their regional distribution is very heterogeneous.
“They are particularly abundant at the border between layers 1 and 2 and in layer 6”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Taniguchi et al., 2013
Chandelier cells are most frequent in layers 2 and 6 although they are preferentially generated toward the end of neurogenesis.
“chandelier cells are most frequent in layers 2 and 6 of neocortex although they are preferentially generated toward the end of neurogenesis”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Taniguchi et al., 2013
Pvalb-MET-5, which contained Pvalb Vipr2 cells, corresponded to chandelier cells as previously identified.
“Pvalb-MET-5 (containing Pvalb Vipr2 cells) represented chandelier cells as previously identified (Woodruff and Yuste, 2008; Taniguchi et al., 2013; Inan and Anderson, 2014; Tasic et al., 2018; Gouwens et al., 2019)”
From Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells (2020) · cites this paper as Taniguchi et al., 2013
The cardinal identity of a cell is probably already instilled at the postmitotic stage during development, and its subsequent phenotypic differentiation and expression are regulated by extrinsic signals such as cell interactions and neural activity.
“The cardinal identity of a cell is probably already instilled at the postmitotic stage during development9,61,62,63,64, and its subsequent phenotypic differentiation and expression are regulated by extrinsic signals such as cell interactions and neural activity.”
From The diversity of GABAergic neurons and neural communication elements (2019) · cites this paper as [63]
As part of its core identity, a cardinal cell type may be driven by its genetic information to establish characteristic connectivity patterns with other appropriate cell types.
“Therefore, as part of its core identity, a cardinal cell type may be driven by its genetic information to establish characteristic connectivity patterns with other appropriate cell types63.”
From The diversity of GABAergic neurons and neural communication elements (2019) · cites this paper as [63]
Both hippocampal and neocortical AACs have origins in the medial ganglionic eminence (MGE) with specification driven by the homeodomain transcription factor Nkx2.1.
“Both hippocampal and neocortical AACs have origins in MGE with specification driven by the homeodomain transcription factor Nkx2.1 (1097, 1137, 1218).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1097]
A large percentage of neocortical AACs are derived late in gestation (~E15-17) from Nkx2.1-expressing progenitors, contrasting with other MGE-derived interneurons that are generated earlier in gestation (~E9-13).
“Interestingly, a large percentage of neocortical AACs are derived late in gestation (~E15–17) from Nkx2.1-expressing progenitors contrasting with other MGE-derived interneurons that are generated earlier in gestation (~E9–13) (1097).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1097]
Temporal dynamics significantly impact mature interneuron fate.
“Complementing the spatial control of interneuron specification within the GEs is a temporal dynamic that has significant impact on mature interneuron fate”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1097]
PV-expressing AAC neurogenesis preferentially occurs beyond E15.5, after the MGE has morphologically flattened into a ventral germinal zone.
“PV-expressing AAC neurogenesis preferentially occurs beyond E15.5 after the MGE has morphologically flattened out into a ventral germinal zone of the lateral ventricle”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1097]
Late MGE progenitors are fate committed to generating AACs by an intrinsic genetic program late in embryogenesis.
“implying that late MGE progenitors are fate committed to generating AACs by an intrinsic genetic program late in embryogenesis”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1097]
SST hub cells are generated from Nkx2.1 progenitors at E9.5, before the MGE is morphologically distinguishable.
“SST hub cells are generated from Nkx2.1 progenitors at the earliest time points of interneuron production (E9.5) before the MGE is even morphologically distinguishable”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1097]
E16.5 Nkx2.1-expressing donor cells transplanted into the somatosensory cortex of P3 hosts reliably differentiated into AACs.
“when E16.5 Nkx2.1 expressing donor cells were transplanted into the somatosensory cortex of P3 hosts, they reliably differentiated into AACs”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1097]
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References 24 · Cited by 278
- Authors
- Taniguchi, H., Lu, J., & Huang, Z. J.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Corresponding author
- Huang, Z. Josh
- Venue
- Science
- Published
- 2013-01-04
- Volume
- 339
- Issue
- 6115
- Pages
- 70-74
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4017638
- OpenAlex
- W2145882818
- Cited by
- 278
- References
- 24
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 16 · 2023: 21 · 2022: 19 · 2021: 25 · 2020: 25 · 2019: 17 · 2018: 23 · 2017: 30 · 2016: 20 · 2015: 10 · 2014: 35 · 2013: 19 · 2012: 1
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 MH094705)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- chandelier cells, GABAergic interneurons, neocortex development, embryonic origin, TTF-1, neuronal migration, cortical lamination, axon initial segment, pyramidal neurons, cortical circuits, mice
- MeSH terms
- Thyroid Nuclear Factor 1, Animals, Female, gamma-Aminobutyric Acid, Interneurons, Mice, Mutant Strains, Nuclear Proteins, Transcription Factors, Pyramidal Cells, Cell Lineage, Neocortex, Lateral Ventricles, Mice, Neural Stem Cells
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