Rapid Folding of DNA into Nanoscale Shapes at Constant Temperature

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A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

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Self-assembly of a nanoscale DNA box with a controllable lid

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Folding DNA into Twisted and Curved Nanoscale Shapes

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Challenges and opportunities for structural DNA nanotechnology

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Rapid prototyping of 3D DNA-origami shapes with caDNAno

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DNA Origami with Complex Curvatures in Three-Dimensional Space

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Complex shapes self-assembled from single-stranded DNA tiles

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From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal

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Room-Temperature and Selective Triggering of Supramolecular DNA Assembly/Disassembly by Nonionizing Radiation

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Thought-Controlled Nanoscale Robots in a Living Host

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Low-cost, simple, and scalable self-assembly of DNA origami nanostructures

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Remote Photothermal Control of DNA Origami Assembly in Cellular Environments

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Driving DNA Origami Coassembling by Vibrational Strong Coupling in the Dark

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Quantifying quality in DNA self-assembly

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Modular self-assembly of gamma-modified peptide nucleic acids in organic solvent mixtures

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Characterizing DNA Star-Tile-Based Nanostructures Using a Coarse-Grained Model

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Reciprocal Control of Hierarchical DNA Origami-Nanoparticle Assemblies

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Synchronization of Two Assembly Processes To Build Responsive DNA Nanostructures

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Design and operation of reconfigurable two-dimensional DNA molecular arrays

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The Art of Designing DNA Nanostructures with CAD Software

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High-speed, high-purity separation of gold nanoparticle–DNA origami constructs using centrifugation

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Modelling DNA origami self-assembly at the domain level

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Isothermal DNA origami folding: avoiding denaturing conditions for one-pot, hybrid-component annealing

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Directing folding pathways for multi-component DNA origami nanostructures with complex topology

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Sites of high local frustration in DNA origami

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DNA nanotechnology: understanding and optimisation through simulation

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Kinetics and Thermodynamics of Watson–Crick Base Pairing Driven DNA Origami Dimerization

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Self-assembly of fully addressable DNA nanostructures from double crossover tiles

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From Designing the Molecules of Life to Designing Life: Future Applications Derived from Advances in DNA Technologies.

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Dielectrophoretic trapping of multilayer DNA origami nanostructures and DNA origami‐induced local destruction of silicon dioxide

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Nanomaterials and nanoclusters based on DNA modulation

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Probing the Formation Kinetics and Thermodynamics with Rationally Designed Analytical Tools Enables One-Pot Synthesis and Purification of a Tetrahedral DNA Nanostructure

Gao, L., Liu, L., Tian, Y., Yang, Q., Wu, P., Fan, C., Zhao, Q., & Li, F. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00363 · Cited by 33

A nanoscale DNA force spectrometer capable of applying tension and compression on biomolecules

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Choosing dyes for cw-STED nanoscopy using self-assembled nanorulers

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Single-molecule assays for investigating protein misfolding and aggregation

Hoffmann, A., Neupane, K., & Woodside, M. T. (2013) · Physical Chemistry Chemical Physics · doi:10.1039/c3cp44564j · Cited by 31

Direct observation and rational design of nucleation behavior in addressable self-assembly

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Functional Applications of Nucleic Acid–Protein Hybrid Nanostructures

McCluskey, J. B., Clark, D. S., & Glover, D. J. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.02.007 · Cited by 33

Computational Approaches to Nucleic Acid Origami

Jabbari, H., Aminpour, M., & Montemagno, C. D. (2015) · ACS Combinatorial Science · doi:10.1021/acscombsci.5b00079 · Cited by 33

Re-entrant swelling and redissolution of polyelectrolytes arises from an increased electrostatic decay length at high salt concentrations

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Influence of thermodynamically unfavorable secondary structures on DNA hybridization kinetics

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Self‐assembled, Programmable DNA Nanodevices for Biological and Biomedical Applications

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The interactions between DNA nanostructures and cells: A critical overview from a cell biology perspective

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Counterions influence the isothermal self-assembly of DNA nanostructures

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Failure Mechanisms in DNA Self-Assembly: Barriers to Single-Fold Yield

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DNA‐templated lithography and nanofabrication for the fabrication of nanoscale electronic circuitry

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Triple-Stranded DNA As a Structural Element in DNA Origami

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DNA Origami Tessellations

Tang, Y., Liu, H., Wang, Q., Qi, X., Lu, Y., Šulc, P., Zhang, F., Yan, H., & Jiang, S. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c03044 · Cited by 26

Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures

Hanke, M., Tomm, E., Grundmeier, G., & Keller, A. (2023) · ChemBioChem · doi:10.1002/cbic.202300338 · Cited by 25

Simulations of DNA-Origami Self-Assembly Reveal Design-Dependent Nucleation Barriers

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Self‐Assembly of DNA Origami and Single‐Stranded Tile Structures at Room Temperature

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Bifunctional DNA Architectonics: Three‐Way Junctions with Sticky Perylene Bisimide Caps and a Central Metal Lock

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Designing Uniquely Addressable Bio-orthogonal Synthetic Scaffolds for DNA and RNA Origami

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Models and simulations of structural DNA nanotechnology reveal fundamental principles of self-assembly.

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Spatial regulation of synthetic and biological nanoparticles by DNA nanotechnology

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Ion-mediated control of structural integrity and reconfigurability of DNA nanostructures

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Isothermal folding of a light-up bio-orthogonal RNA origami nanoribbon

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Helical DNA Origami Tubular Structures with Various Sizes and Arrangements

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Competitive annealing of multiple DNA origami: formation of chimeric origami

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Temperature Mapping in Hydrogel Matrices Using Unmodified Digital Camera

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Directional Assembly of Nanoparticles by DNA Shapes: Towards Designed Architectures and Functionality

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A label-free light-scattering method to resolve assembly and disassembly of DNA nanostructures

Ijäs, H., Liedl, T., Linko, V., & Posnjak, G. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.10.036 · Cited by 21

TOPOFOLD , the designed modular biomolecular folds: polypeptide‐based molecular origami nanostructures following the footsteps of DNA

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Multi-scale coarse-graining for the study of assembly pathways in DNA-brick self-assembly

Fonseca, P., Romano, F., Schreck, J. S., Ouldridge, T. E., Doye, J. P. K., & Louis, A. A. (2018) · The Journal of Chemical Physics · doi:10.1063/1.5019344 · Cited by 21

Probing Heterogeneous Folding Pathways of DNA Origami Self-Assembly at the Molecular Level with Atomic Force Microscopy

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Genetically Encoded and Biologically Produced All‐DNA Nanomedicine Based on One‐Pot Assembly of DNA Dendrimers for Targeted Gene Regulation

Lu, J., Hu, P., Cao, L., Wei, Z., Xiao, F., Chen, Z., Li, Y., & Tian, L. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202012916 · Cited by 21

Application of Nucleic Acid Frameworks in the Construction of Nanostructures and Cascade Biocatalysts: Recent Progress and Perspective

Zhu, G., Song, P., Wu, J., Luo, M., Chen, Z., & Chen, T. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.792489 · Cited by 20

Revealing thermodynamics of DNA origami folding via affine transformations

Majikes, J. M., Patrone, P. N., Schiffels, D., Zwolak, M. P., Kearsley, A. J., Forry, S. P., & Liddle, J. A. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa283 · Cited by 19

Meshing complex macro-scale objects into self-assembling bricks

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Barcode extension for analysis and reconstruction of structures

Myhrvold, C., Baym, M., Hanikel, N., Ong, L. L., Gootenberg, J. S., & Yin, P. (2017) · Nature Communications · doi:10.1038/ncomms14698 · Cited by 18

Lattice models and Monte Carlo methods for simulating DNA origami self-assembly

Cumberworth, A., Reinhardt, A., & Frenkel, D. (2018) · The Journal of Chemical Physics · doi:10.1063/1.5051835 · Cited by 18

The path towards functional nanoparticle-DNA origami composites

Johnson, J. A., Dehankar, A., Robbins, A., Kabtiyal, P., Jergens, E., Lee, K. H., Johnston‐Halperin, E., Poirier, M. G., Castro, C. E., & Winter, J. O. (2019) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2019.06.003 · Cited by 18

Self‐Assembly of a 3D DNA Crystal Structure with Rationally Designed Six‐Fold Symmetry

Zhang, F., Simmons, C. R., Gates, J., Liu, Y., & Yan, H. (2018) · Angewandte Chemie · doi:10.1002/ange.201807223 · Cited by 18

DNA nanotechnology: a curiosity or a promising technology?

Tørring, T., & Gothelf, K. V. (2013) · F1000Prime Reports · doi:10.12703/p5-14 · Cited by 18

Synchronization of Two Assembly Processes To Build Responsive DNA Nanostructures

Nie, Z., Wang, P., Tian, C., & Mao, C. (2014) · Angewandte Chemie · doi:10.1002/ange.201404307 · Cited by 16

NucleoCraft: The Art of Stimuli-Responsive Precision in DNA and RNA Bioengineering

Lu, Y., Chen, L., Satyabola, D., Prasad, A., & Yan, H. (2024) · BME Frontiers · doi:10.34133/bmef.0050 · Cited by 17

Label as you fold: methyltransferase-assisted functionalization of DNA nanostructures

Heck, C., Torchinsky, D., Nifker, G., Gularek, F., Michaeli, Y., Weinhold, E. G., & Ebenstein, Y. (2020) · Nanoscale · doi:10.1039/d0nr03694c · Cited by 16

Biotemplated precise assembly approach toward ultra-scaled high-performance electronics

Chen, Y., Zhao, M., Ouyang, Y., Zhang, S., Liu, Z., Wang, K., Zhang, Z., Liu, Y., Yang, C. J., Sun, W., et al. (2023) · Nature Protocols · doi:10.1038/s41596-023-00870-3 · Cited by 14

Biodistribution and function of coupled polymer-DNA origami nanostructures

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Description of DNA molecular motion for nanotechnology applications

Awaja, F., Wakelin, E. A., Sage, J., & Altaee, A. (2015) · Progress in Materials Science · doi:10.1016/j.pmatsci.2015.03.001 · Cited by 14

Self-assembly and nanoaggregation of a pH responsive DNA hybrid amphiphile

Yan, Y., Sun, Y., Yu, H., Xu, H., & Lu, J. R. (2015) · Soft Matter · doi:10.1039/c4sm02499k · Cited by 14

Universal pH‐Responsive and Metal‐Ion‐Free Self‐Assembly of DNA Nanostructures

Li, Y., Song, L., Wang, B., He, J., Li, Y., Deng, Z., & Mao, C. (2018) · Angewandte Chemie · doi:10.1002/ange.201804054 · Cited by 14

Fast synthesis of DNA origami single crystals at room temperature

Yu, Y., Ji, M., Wang, Y., Yan, X., Dai, L., Ma, N., Zhou, Z., Xing, H., & Tian, Y. (2024) · Chemical Science · doi:10.1039/d4sc07267g · Cited by 13

An Assembly Funnel Makes Biomolecular Complex Assembly Efficient

Zenk, J., & Schulman, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111233 · Cited by 12

Probing the self-assembly process of amphiphilic tetrahedral DNA frameworks

Liang, C., Chen, J., Li, M., Ge, Z., Fan, C., & Shen, J. (2022) · Chemical Communications · doi:10.1039/d2cc03451d · Cited by 13

Insights into the Structure and Energy of DNA Nanoassemblies

Jaekel, A., Lill, P., Whitelam, S., & Saccà, B. (2020) · Molecules · doi:10.3390/molecules25235466 · Cited by 13

Folding and Imaging of DNA Nanostructures in Anhydrous and Hydrated Deep‐Eutectic Solvents

Gállego, I., Grover, M. A., & Hud, N. V. (2015) · Angewandte Chemie · doi:10.1002/ange.201412354 · Cited by 14

Bidirectional linkage of DNA barcodes for the multiplexed mapping of higher-order protein interactions in cells

Liu, Y., Sundah, N. R., Ho, N. R. Y., Shen, W. X., Xu, Y., Natalia, A., Yu, Z., Seet, J. E., Chan, C. W., Loh, T. P., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01225-3 · Cited by 13

DNA Nanotechnology for Building Sensors, Nanopores and Ion-Channels

Göpfrich, K., & Keyser, U. F. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9791-2_11 · Cited by 12

DNA origami structures as calibration standards for nanometrology

Korpelainen, V., Linko, V., Seppä, J., Lassila, A., & Kostiainen, M. A. (2017) · Measurement Science and Technology · doi:10.1088/1361-6501/28/3/034001 · Cited by 12

Reversible Covalent Stabilization of Stacking Contacts in DNA Assemblies

Gerling, T., & Dietz, H. (2019) · Angewandte Chemie · doi:10.1002/ange.201812463 · Cited by 11

Sequence-specific recognition of DNA nanostructures

Rusling, D. A., & Fox, K. R. (2014) · Methods · doi:10.1016/j.ymeth.2014.02.028 · Cited by 11

Toward quantitative fluorescence microscopy with DNA origami nanorulers

Beater, S., Raab, M., & Tinnefeld, P. (2014) · Methods in cell biology · doi:10.1016/b978-0-12-420138-5.00024-0 · Cited by 11

The Kinematic Principle for Designing Deoxyribose Nucleic Acid Origami Mechanisms: Challenges and Opportunities1

Su, H., Castro, C. E., Marras, A. E., & Zhou, L. (2017) · Journal of Mechanical Design · doi:10.1115/1.4036216 · Cited by 11

Nanotubes Growth by Self-Assembly of DNA Strands at Room Temperature

Bourdon, L., Afrose, S. P., Agarwal, S., Das, D., Singh, R., Cicco, A. D., Lévy, D., Yamada, A., Baigl, D., & Franco, E. (2025) · ACS Nano · doi:10.1021/acsnano.4c17516 · Cited by 10

Base‐Sequence‐Independent Efficient Redox Switching of Self‐Assembled DNA Nanocages

Wang, B., Song, L., Jin, B., Deng, N., Wu, X., He, J., Deng, Z., & Li, Y. (2019) · ChemBioChem · doi:10.1002/cbic.201900253 · Cited by 10

Applying dynamic light scattering to investigate the self-assembly process of DNA nanostructures

Yuan, W., Dong, G., Ning, H., Guan, X.-X., Cheng, J., Shi, Z.-W., Du, X., Meng, S.-W., Liu, D., & Dong, Y.-C. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.108384 · Cited by 10

AFM-Based Probing of the Flexibility and Surface Attachment of Immobilized DNA Origami

Thamm, S., Slesiona, N., Dathe, A., Csáki, A., & Fritzsche, W. (2018) · Langmuir · doi:10.1021/acs.langmuir.8b02362 · Cited by 10

A lock-and-key mechanism for the controllable fabrication of DNA origami structures

Rajendran, A., Endo, M., Hidaka, K., Shimada, N., Maruyama, A., & Sugiyama, H. (2014) · Chemical Communications · doi:10.1039/c4cc02244k · Cited by 10

Engineering Defined Motor Ensembles with DNA Origami

Goodman, B. S., & Reck‐Peterson, S. L. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-397924-7.00010-8 · Cited by 10

Search for effective chemical quenching to arrest molecular assembly and directly monitor DNA nanostructure formation

Majikes, J. M., Nash, J. A., & LaBean, T. H. (2016) · Nanoscale · doi:10.1039/c6nr08433h · Cited by 10

Conformational Control of DNA Origami by DNA Oligomers, Intercalators and UV Light

Li, R., Chen, H., Lee, H., & Choi, J. H. (2021) · Methods and Protocols · doi:10.3390/mps4020038 · Cited by 9

Design principles for accurate folding of DNA origami

Aksel, T., Navarro, E. J., Fong, N., & Douglas, S. M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2406769121 · Cited by 9

Investigating the aggregation behaviour of DNA origami frames

Fischer, F., Henning‐Knechtel, A., & Mertig, M. (2015) · physica status solidi (a) · doi:10.1002/pssa.201431931 · Cited by 9

Cooperativity-based modeling of heterotypic DNA nanostructure assembly

Shapiro, A., Hozeh, A., Girshevitz, O., Abu-Horowitz, A., & Bachelet, I. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv602 · Cited by 11

Grafting from a Hybrid DNA–Covalent Polymer by the Hybridization Chain Reaction

Noteborn, W. E. M., Wondergem, J. A. J., Iurchenko, A., Chariyev‐Prinz, F., Donato, D. M., Voets, I. K., Heinrich, D., & Kieltyka, R. E. (2018) · Macromolecules · doi:10.1021/acs.macromol.7b02610 · Cited by 9

Studying the adsorption of DNA nanostructures on graphene in the aqueous phase using molecular dynamic simulations

Sun, J., Li, Y., & Lin, J. (2017) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2017.03.003 · Cited by 9

Multiplexed Detection of Molecular Interactions with DNA Origami Engineered Cells in 3D Collagen Matrices

Shahhosseini, M., Beshay, P. E., Akbari, E., Roki, N., Lucas, C. R., Avendano, A., Song, J. W., & Castro, C. E. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c07971 · Cited by 8

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Amir, Y., Abu-Horowitz, A., & Bachelet, I. (2015) · Journal of Visualized Experiments · doi:10.3791/51272 · Cited by 8

Effect of Temperature Ramp in Rapid Folding of 3D DNA Origami Structures

Dey, A., Hussain, M. M. A. A., Pham, X., Loo, J. F.-C., Natarajan, A. K., & Kuzyk, A. (2025) · Small Structures · doi:10.1002/sstr.202500682

Cover Feature: Effect of Temperature Ramp in Rapid Folding of 3D DNA Origami Structures (Small Struct. 2/2026)

Dey, A., Hussain, M. M. A. A., Pham, X., Loo, J. F.-C., Natarajan, A. K., & Kuzyk, A. (2026) · Small Structures · doi:10.1002/sstr.70359

Single Molecule Force Control Drives the Rapid Assembly of DNA Nanostructure

Bae, W., Kim, K., Min, D., Ryu, J., Hyeon, C., & Yoon, T. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2013.11.1634

Folding of DNA origamis

Arbona, J., Aimé, J., & Elezgaray, J. (2012) · Frontiers in Life Science · doi:10.1080/21553769.2013.768556 · Cited by 5

Nurturing Nature for Nanotechnology

Zwolak, M. P. (2019) · Biophysical Journal · doi:10.1016/j.bpj.2018.11.217