The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Rapid Folding of DNA into Nanoscale Shapes at Constant Temperature
Abstract
Speeding Up Nanoscale DNA Assembly: An impressive array of three-dimensional (3D) nanoscale objects has been assembled by folding a long, single-stranded DNA scaffold by binding of short DNA staples. However, these processes tend to be slow and inefficient. Sobczak et al. (p. 1458 ) examined the folding process with an intercalating fluorescence dye to measure the formation of double-stranded DNA in folding processes or single-stranded DNA in unfolding. Reaction conditions were identified that sped up folding by orders of magnitude and increased yields of the 3D nanoscale objects to nearly 100%.
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“Because of the noncovalent nature of DNA nanostructures, they can be reconfigured using established strategies, including strand displacement,26 thermal annealing,105 and pH changes.106”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [105]
Citations
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Self-citation
Metadata
- Authors
- Sobczak, J.-P. J., Martin, T. G., Gerling, T., & Dietz, H.
- Affiliations
- Technical University of Munich (DE)
- Corresponding author
- Dietz, Hendrik
- Venue
- Science
- Published
- 2012-12-14
- Volume
- 338
- Issue
- 6113
- Pages
- 1458-1461
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049040320
- Cited by
- 285
- References
- 29
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 17 · 2023: 18 · 2022: 18 · 2021: 13 · 2020: 15 · 2019: 20 · 2018: 25 · 2017: 24 · 2016: 28 · 2015: 26 · 2014: 42 · 2013: 15 · 2012: 2
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Mathematics › Theoretical Computer Science › DNA and Biological Computing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- DNA folding, DNA nanotechnology, cooperative folding, nucleation, DNA origami, folding kinetics, DNA topology
- MeSH terms
- DNA, Nucleic Acid Conformation, Temperature, Templates, Genetic, Protein Folding, Nanotechnology, Nanostructures
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