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A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy
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Red in Cell and Marrow: About one hundred billion new red cells are released every day from the adult human bone marrow—the result of a complex differentiation pathway. Barde et al. (p. 350 , published online 14 March) show that an essential step in this process, the elimination of mitochondria from maturing erythroblasts through mitophagy, is controlled through the timely induction of specific members of the large family of KRAB-containing zinc finger proteins (KRAB-ZFPs), which, together with their cofactor KAP1, repress the expression of micro-RNAs targeting the transcripts of mitophagy effector genes. This multilayered and combinatorial regulation system provides a level of modularity that may be shared by other physiological processes.
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“miR-351 and miR-125a are also known to regulate mitophagy [49].”
From miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) (2016) · cites this paper as [49]
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Metadata
- Authors
- Barde, I., Rauwel, B., Marin-Florez, R. M., Corsinotti, A., Laurenti, E., Verp, S., Offner, S., Marquis, J., Kapopoulou, A., Vanicek, J., & Trono, D.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- School of Basic Sciences, EPFL, 1015 Lausanne, Switzerland.
- Corresponding author
- Trono, Didier
- ORCID
- Venue
- Science
- Published
- 2013-04-19
- Volume
- 340
- Issue
- 6130
- Pages
- 350-353
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3678075
- OpenAlex
- W1989966286
- Cited by
- 111
- References
- 39
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 11 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 17 · 2013: 6
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
- IRIS (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Science Foundation
- Cincinnati Children's Hospital Medical Center
- École Polytechnique Fédérale de Lausanne
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- KRAB zinc finger proteins, KAP1, mitophagy, erythropoiesis, microRNA regulation, erythroblasts, hypoproliferative anemia, hematopoiesis, transcriptional repression, chromatin modifiers, mitochondrial clearance
- MeSH terms
- Tripartite Motif-Containing Protein 28, Anemia, Animals, Autophagy, Erythroblasts, Erythropoiesis, Female, Male, Membrane Proteins, Mice, Inbred C57BL, Mitochondria, Nuclear Proteins, Repressor Proteins, Transcription Factors, Zinc Fingers, Mice, Knockout, Mitochondrial Proteins, MicroRNAs, Mice
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