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From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

Hattangadi, Shilpa M., Wong, Piu, Zhang, Lingbo, Flygare, Johan, Lodish, Harvey F.·2011·Blood
DOI 10.1182/blood-2011-07-356006
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Abstract

This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis.

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Metadata

Authors
Hattangadi, S. M., Wong, P., Zhang, L., Flygare, J., & Lodish, H. F.
Affiliations
Whitehead Institute for Biomedical Research, Cambridge, MA;
Venue
Blood
Publisher
American Society of Hematology
Published
2011-12-08
Volume
118
Issue
24
Pages
6258-6268
ISSN
  • 0006-4971
  • 1528-0020
DOI
10.1182/blood-2011-07-356006
Cited by
423
References
11
Language
en

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