The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Interferon-ε Protects the Female Reproductive Tract from Viral and Bacterial Infection
Open accessAbstract
A Role for IFN-ɛ: Type I interferons (IFNs) are critical cytokines involved in host defense against pathogens, particularly viruses. IFN-ɛ is an IFN-like gene encoded within the type I IFN locus in mice and humans whose function has not been characterized. Fung et al. (p. 1088 ) created mice with a genetic deletion in Ifn -ɛ and found that, like other type I IFNs, IFN-ɛ signals through the IFN-α receptors 1 and 2. However, unlike these other cytokines, which are primarily expressed by immune cells and are induced upon immune cell triggering, IFN-ɛ was expressed exclusively by epithelial cells of the female reproductive tract in both mice and humans and its expression was hormonally regulated. IFN-ɛ–deficient mice were more susceptible to infection with herpes simplex virus 2 and Chlamydia muridarum , two common sexually transmitted pathogens.
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Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Virus interference. I. the interferon
Isaacs, A., & Lindenmann, J. (1957) · Proceedings of the Royal Society of London. Series B - Biological Sciences · doi:10.1098/rspb.1957.0048 · Cited by 3,451
Cited by
Shared and Distinct Functions of Type I and Type III Interferons
Lazear, H. M., Schoggins, J. W., & Diamond, M. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.025 · Cited by 1,138
Decoding type I and III interferon signalling during viral infection
Mesev, E. V., LeDesma, R. A., & Ploss, A. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0421-x · Cited by 538
Barriga, F. M., Tsanov, K. M., Ho, Y.-J., Sohail, N., Zhang, A., Baslan, T., Wuest, A. N., Del Priore, I., Meškauskaitė, B., Livshits, G., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00443-5 · Cited by 125
Bain, C. C., Gibson, D. A., Steers, N. J., Boufea, K., Louwe, P. A., Doherty, C., González-Huici, V., Gentek, R., Magalhaes-Pinto, M., Shaw, T., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abc4466 · Cited by 97
Interfering with immunity: detrimental role of type I IFNs during infection
Stifter, S. A., & Feng, C. G. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402794 · Cited by 78
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Metadata
- Authors
- Fung, K. Y., Mangan, N. E., Cumming, H., Horvat, J. C., Mayall, J. R., Stifter, S. A., De Weerd, N., Roisman, L. C., Rossjohn, J., Robertson, S. A., Schjenken, J. E., Parker, B., Gargett, C. E., Nguyen, H. P. T., Carr, D. J., Hansbro, P. M., & Hertzog, P. J.
- Venue
- Science
- Published
- 2013-03
- Volume
- 339
- Issue
- 6123
- Pages
- 1088-1092
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061546617
- Cited by
- 261
- References
- 2
- FWCI
- 11.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Fung, K. Y., Mangan, N. E., Cumming, H., Horvat, J. C., Mayall, J. R., Stifter, S. A., De Weerd, N., Roisman, L. C., Rossjohn, J., Robertson, S. A., Schjenken, J. E., Parker, B., Gargett, C. E., Nguyen, H. P. T., Carr, D. J., Hansbro, P. M., & Hertzog, P. J. (2013). Interferon-ε Protects the Female Reproductive Tract from Viral and Bacterial Infection. Science. https://doi.org/10.1126/science.1233321
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