Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages
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Abstract
Peritoneal macrophages exhibit sexually dimorphic transcriptional profiles, functional capacity, and replenishment kinetics.
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Recent studies have shown that SPMs can continue to alter their functional and transcriptional profiles to look more like LPMs, and even occupy that same niche over time.
“recent studies have shown that not only can SPMs continue to alter their functional and transcriptional profiles to look more like LPMs, and even occupy that same niche over time”
From Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner (2024) · cites this paper as [40]
The Results section on scRNA-seq (page unavailable) describes an intermediate transcriptional phenotype between small F4/80loMHCII+ macrophages and resident CD102+ macrophages; fate-mapping results support derivation of some resident cells from the small-cell population. The Discussion (page unavailable) treats further progression toward the long-lived resident population as a possibility, particularly in females, but says a linear progression is unlikely in males. These passages do not establish that small macrophages acquire the large macrophages’ functional profile, and the claim states the progression more definitively than the paper does. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThere are distinct sex-differences in pMac populations.
“Based on the literature indicating distinct sex-differences in pMac populations, we aimed to determine whether the P522R mutation would have similar effects on population frequencies and antigen presentation in female mice as was seen in male mice [40].”
From Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner (2024) · cites this paper as [40]
pMac sub-populations are not static.
“as these sub-populations are not static regardless.”
From Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner (2024) · cites this paper as [40]
SPMs do so more readily in males.
“but they actually do so more readily in males [30, 40].”
From Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner (2024) · cites this paper as [40]
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Percentages, sums and reported differences re-computed from the paper’s own numbers.
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Cites
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“3 clusters of resident 30 macrophages (3-5) could be identified on the basis of their high expression of Adgre1 (F4/80) and Icam2 31 (CD102).”
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Dick, S. A., Wong, A., Hamidzada, H., Nejat, S., Nechanitzky, R., Vohra, S., Mueller, B., Zaman, R., Kantores, C., Aronoff, L., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abf7777 · Cited by 538 · see citing works
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“Based on the literature indicating distinct sex-differences in pMac populations, we aimed to determine whether the P522R mutation would have similar effects on population frequencies and antigen presentation in female mice as was seen in male mice [40].”
Background
- Authors
- Bain, C. C., Gibson, D. A., Steers, N. J., Boufea, K., Louwe, P. A., Doherty, C., González-Huici, V., Gentek, R., Magalhaes-Pinto, M., Shaw, T., Bajénoff, M., Bénézech, C., Walmsley, S. R., Dockrell, D. H., Saunders, P. T. K., Batada, N. N., & Jenkins, S. J.
- Affiliations
- Centre for Inflammation Research (GB)
- Columbia University Irving Medical Center (US)
- Institute of Genetics and Cancer (GB)
- Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
- Centre National de la Recherche Scientifique (FR)
- Lydia Becker Institute for Immunology and Infection, Faculty of Biology, Medicine and Health, Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK.
- University of Manchester (GB)
- University of Edinburgh (GB)
- Corresponding author
- Bain, C. C.
- Jenkins, S. J.
- ORCID
- Venue
- Science Immunology
- Published
- 2020-06-26
- Volume
- 5
- Issue
- 48
- Pages
- eabc4466
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC7610697
- OpenAlex
- W3036963660
- Cited by
- 97
- References
- 15
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 13 · 2023: 16 · 2022: 17 · 2021: 20 · 2020: 5
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Science Immunology (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome (IS3-R34, 203909/Z/16/A, 206234/Z/17/Z, 209220)
- Medical Research Council (MR/L008076/1, MR/N024524/1)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- peritoneal macrophages, sex differences, bone marrow, macrophage turnover, microenvironment, pneumococcal peritonitis, aging
- MeSH terms
- Animals, Cell Differentiation, Female, Homeostasis, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Phenotype, RNA, Sex Characteristics, Sequence Analysis, RNA, Macrophages, Peritoneal, Mice, Knockout, Mice, Congenic, Mice, Single-Cell Analysis
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