The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
B Cells Use Mechanical Energy to Discriminate Antigen Affinities
Open accessAbstract
B Cell Tug of War: High-affinity, protective antibodies made by B cells are critical for providing long-term protection against reinfection. In order to produce antibodies, B cells must first bind to and extract antigens from the surface of antigen-presenting cells. Using an in vitro system that allows B cells to bind to antigenladen, flexible membranes, Natkanski et al. (p. 1587 , published online 16 May) show that antigen extraction relies on myosin IIA–mediated contractile forces that pull upon the antigen-presenting membrane. These forces break the antigen-receptor bonds if affinity is low, thus ensuring that B cells only extract, internalize, and presumably respond to, high-affinity antigens.
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Role of nanoscale antigen organization on B-cell activation probed using DNA origami
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Modulating extracellular matrix stiffness: A strategic approach to boost cancer immunotherapy
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Systems‐wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation
Satpathy, S., Wagner, S. A., Beli, P., Gupta, R., Kristiansen, T. A., Malinova, D., Francavilla, C., Tolar, P., Bishop, G. A., Hostager, B. S., et al. (2015) · Molecular Systems Biology · doi:10.15252/msb.20145880 · Cited by 124
Self-citationMittelheisser, V., Gensbittel, V., Bonati, L., Li, W., Tang, L., & Goetz, J. G. (2024) · Nature Nanotechnology · doi:10.1038/s41565-023-01535-8 · Cited by 109
Metadata
- Authors
- Natkanski, E., Lee, W.-Y., Mistry, B., Casal, A., Molloy, J. E., & Tolar, P.
- Venue
- Science
- Published
- 2013-06-28
- Volume
- 340
- Issue
- 6140
- Pages
- 1587-1590
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2018521012
- Cited by
- 321
- References
- 36
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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