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The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Genome-Wide Comparison of Medieval and Modern Mycobacterium leprae

Schuenemann, Verena J., Singh, Pushpendra, Mendum, Thomas A., Krause-Kyora, Ben, Jäger, Günter, Bos, Kirsten I., Herbig, Alexander, Economou, Christos, Benjak, Andrej, Busso, Philippe, Nebel, Almut, Boldsen, Jesper L., Kjellström, Anna, Wu, Huihai, Stewart, Graham R., Taylor, G. Michael, Bauer, Peter, Lee, Oona Y.-C., Wu, Houdini H.T., Minnikin, David E., Besra, Gurdyal S., Tucker, Katie, Roffey, Simon, Sow, Samba O., Cole, Stewart T., Nieselt, Kay, Krause, Johannes·2013·Science
DOI 10.1126/science.1238286
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Abstract

Leprosy: Ancient and Modern: In medieval Europe, leprosy was greatly feared: Sufferers had to wear bells and were shunned and kept isolated from society. Although leprosy largely disappeared from Europe in the 16th century, elsewhere in the world almost a quarter of a million cases are still reported annually, despite the availability of effective drugs. Schuenemann et al. (p. 179 , published online 13 June; see the 14 June News story by Gibbons , p. 1278 ) probed the origins of leprosy bacilli by using a genomic capture-based approach on DNA obtained from skeletal remains from the 10th to 14th centuries. Because the unique mycolic acids of this mycobacterium protect its DNA, for one Danish sample over 100-fold, coverage of the genome was possible. Sequencing suggests a link between the middle-eastern and medieval European strains, which falls in line with social historical expectations that the returning expeditionary forces of antiquity originally spread the pathogen. Subsequently, Europeans took the bacterium westward to the Americas. Overall, ancient and modern strains remain remarkably similar, with no apparent loss of virulence genes, indicating it was most probably improvements in social conditions that led to leprosy's demise in Europe.

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Crossref · 10.1126/science.1238286

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  • The limited length of aDNA and the presence of often dominant environmental microbial DNA contamination have precluded widespread usage of de novo sequence assembly.

    “Although with exceptions 177 , the limited length of aDNA and the presence of often dominant environmental microbial DNA contamination have precluded widespread usage of de novo sequence assembly.”

    From Ancient DNA analysis (2021) · cites this paper as [177]

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Metadata

Authors
Schuenemann, V. J., Singh, P., Mendum, T. A., Krause-Kyora, B., Jäger, G., Bos, K. I., Herbig, A., Economou, C., Benjak, A., Busso, P., Nebel, A., Boldsen, J. L., Kjellström, A., Wu, H., Stewart, G. R., Taylor, G. M., Bauer, P., Lee, O. Y.-C., Wu, H. H. T., Minnikin, D. E., Besra, G. S., Tucker, K., Roffey, S., Sow, S. O., Cole, S. T., Nieselt, K., & Krause, J.
Affiliations
  • Institute for Archaeological Sciences, University of Tübingen, 72070 Tübingen, Germany.
  • Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
  • Department of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH Surrey, UK.
  • Institute of Clinical Molecular Biology, Kiel University, 24105 Kiel, Germany.
  • Center for Bioinformatics, University of Tübingen, 72076 Tübingen, Germany.
  • Archaeological Research Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
  • Institute of Forensic, Antropologisk Afdelin, Medicine University of Southern Denmark, 5260 Odense S, Denmark.
  • Osteoarchaeological Research Laboratory, Department of Archaeology and Classical Studies, Stockholm University, SE-106 91 Stockholm, Sweden.
  • Institute for Medical Genetics and Applied Genomics, University of Tübingen, 72076 Tübingen, Germany.
  • School of Biosciences, University of Birmingham, Edgbaston, B15 2TU Birmingham, UK.
  • Department of Archaeology, University of Winchester, Sparkford Road, SO22 4NR Winchester, UK.
  • Center for Vaccine Development-Mali, Ministry of Health, Centre National d’Appui à la lutte contre la Maladie–ex-Institut Marchoux, BP 251 Bamako, Mali.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2013-07-12
Volume
341
Issue
6142
Pages
179-183
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1238286
Cited by
358
References
9
Language
en

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