The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Pou5f1 Transcription Factor Controls Zygotic Gene Activation In Vertebrates
Abstract
Pluripotency Control: The transcription factors Pou5f1/Oct4, Sox2, and Nanog play central roles in pluripotency control in mammalian embryonic stem (ES) cells. The evolution of the pluripotency regulatory network and its roles during early development of nonmammalian vertebrates is unknown. Leichsenring et al. (p. 1005 , published online 15 August) show that in zebrafish embryos, Pou5f1 controls priming and transcriptional activation of the first zygotically expressed genes. This mechanism for transition from the transcriptionally silent cleavage stage to the transcriptionally active blastula stage may have evolved to control the prolonged cell pluripotency state in mammalian early development and ES cells, establishing a link between zygotic gene activation and pluripotency control.
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Cites
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Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs
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The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila
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Cited by
Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming
Soufi, A., Garcia, M. F., Jaroszewicz, A., Osman, N., Pellegrini, M., & Zaret, K. S. (2015) · Cell · doi:10.1016/j.cell.2015.03.017 · Cited by 780
“Notably, the pioneer activity of a Zebrafish homolog of an Oct protein was observed during the maternal-to-zygote transition (Lee et al., 2013; Leichsenring et al., 2013), suggesting that targeting nucleosomal sites may be a general method for de novo programming of the genome.”
Mechanisms regulating zygotic genome activation
Schulz, K. N., & Harrison, M. M. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0087-x · Cited by 555
Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition
Lee, M. T., Bonneau, A. R., Takacs, C. M., Bazzini, A. A., DiVito, K. R., Fleming, E. S., & Giraldez, A. J. (2013) · Nature · doi:10.1038/nature12632 · Cited by 503
The maternal-to-zygotic transition revisited
Vastenhouw, N. L., Cao, W. X., & Lipshitz, H. D. (2019) · Development · doi:10.1242/dev.161471 · Cited by 445
A high-resolution mRNA expression time course of embryonic development in zebrafish
White, R. J., Collins, J. E., Sealy, I. M., Wali, N., Dooley, C. M., Digby, Z., Stemple, D. L., Murphy, D. N., Billis, K., Hourlier, T., et al. (2017) · eLife · doi:10.7554/elife.30860 · Cited by 361
Metadata
- Authors
- Leichsenring, M., Maes, J., Mössner, R., Driever, W., & Onichtchouk, D.
- Venue
- Science
- Published
- 2013-08-30
- Volume
- 341
- Issue
- 6149
- Pages
- 1005-1009
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060713924
- Cited by
- 231
- References
- 10
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Leichsenring, M., Maes, J., Mössner, R., Driever, W., & Onichtchouk, D. (2013). Pou5f1 Transcription Factor Controls Zygotic Gene Activation In Vertebrates. Science. https://doi.org/10.1126/science.1242527
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