The DOI matches its Crossref record; 194 of the 194 references it cites were found in a registry or an index.
Mechanisms regulating zygotic genome activation
Open accessAbstract
Following fertilization, the two specified gametes must unite to create an entirely new organism. The genome is initially transcriptionally quiescent, allowing the zygote to be reprogrammed into a totipotent state. Gradually, the genome is activated through a process known as the maternal-to-zygotic transition, which enables zygotic gene products to replace the maternal supply that initiated development. This essential transition has been broadly characterized through decades of research in several model organisms. However, we still lack a full mechanistic understanding of how genome activation is executed and how this activation relates to the reprogramming of the zygotic chromatin architecture. Recent work highlights the central role of transcriptional activators and suggests that these factors may coordinate transcriptional activation with other developmental changes. The maternal-to-zygotic transition (MZT) is the process by which the transcriptionally silent embryonic genome is gradually activated. The mechanisms underlying the MZT are not fully understood, but recent work indicates that transcriptional activators have an important role.
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1 retracted
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Cited by
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Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
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Lineage tracing of human development through somatic mutations
Spencer Chapman, M., Ranzoni, A. M., Myers, B., Williams, N., Coorens, T. H. H., Mitchell, E., Butler, T., Dawson, K. J., Hooks, Y., Moore, L., et al. (2021) · Nature · doi:10.1038/s41586-021-03548-6 · Cited by 167
Metadata
- Authors
- Schulz, K. N., & Harrison, M. M.
- Venue
- Nature Reviews Genetics
- Published
- 2018-12-20
- Volume
- 20
- Issue
- 4
- Pages
- 221-234
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2905550051
- Cited by
- 555
- References
- 194
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- green
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