Cited by 447IL-33, ST2, and ILC PathwaysT-cell and B-cell ImmunologyImmune responses and vaccinations

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Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

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Spencer, S. P., Wilhelm, C., Yang, Q., Hall, J. A., Bouladoux, N., Boyd, A., Nutman, T. B., Urban, J. F., Wang, J., Ramalingam, T. R., Bhandoola, A., Wynn, T. A., Belkaid, Y.·2014·Science

DOI 10.1126/science.1247606PMC PMC4313730

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Abstract

How the immune system adapts to malnutrition to sustain immunity at barrier surfaces, such as the intestine, remains unclear. Vitamin A deficiency is one of the most common micronutrient deficiencies and is associated with profound defects in adaptive immunity. Here, we found that type 3 innate lymphoid cells (ILC3s) are severely diminished in vitamin A–deficient settings, which results in compromised immunity to acute bacterial infection. However, vitamin A deprivation paradoxically resulted in dramatic expansion of interleukin-13 (IL-13)–producing ILC2s and resistance to nematode infection in mice, which revealed that ILCs are primary sensors of dietary stress. Further, these data indicate that, during malnutrition, a switch to innate type 2 immunity may represent a powerful adaptation of the immune system to promote host survival in the face of ongoing barrier challenges.

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Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358
Innate lymphoid cells — a proposal for uniform nomenclature
Spits, H., Artis, D., Colonna, M., Diefenbach, A., Disanto, J. D., Eberl, G., Koyasu, S., Locksley, R., McKenzie, A., Mebius, R., et al. (2013) · Nature reviews. Immunology · doi:10.1038/nri3365 · Cited by 2,380
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880
Self-citation
Mucin dynamics and enteric pathogens
McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428
Malnutrition and Infection: Complex Mechanisms and Global Impacts
Schaible, U. E., & Kaufmann, S. H. E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040115 · Cited by 991
IL-13 Effector Functions
Wynn, T. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141142 · Cited by 991
Self-citation
The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells
Qiu, J., Heller, J. J., Guo, X., Chen, Z. E., Fish, K., Fu, Y., & Zhou, L. (2011) · Immunity · doi:10.1016/j.immuni.2011.11.011 · Cited by 889
The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells
Hoyler, T., Klose, C. S. N., Souabni, A., Turqueti‐Neves, A., Pfeifer, D., Rawlins, E. L., Voehringer, D., Busslinger, M., & Diefenbach, A. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.020 · Cited by 873
The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling
Spits, H., & Santo, J. P. D. (2010) · Nature Immunology · doi:10.1038/ni.1962 · Cited by 840
Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation
Li, Y., Innocentin, S., Withers, D. R., Roberts, N. A., Gallagher, A., Grigorieva, E. F., Wilhelm, C., & Veldhoen, M. (2011) · Cell · doi:10.1016/j.cell.2011.09.025 · Cited by 837
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Chen, X., & Mayne, C. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02853 · Cited by 14
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Leupold, T., & Wirtz, S. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214200 · Cited by 13
Diet composition drives tissue-specific intensity of murine enteric infections
Israelson, H., Vedsted-Jakobsen, A., Zhu, L., Gagnaire, A., von Münchow, A., Polakovicova, N., Valente, A. H., Raza, A., Andersen‐Civil, A. I. S., Olsen, J. E., et al. (2024) · mBio · doi:10.1128/mbio.02603-23 · Cited by 12
Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice
Ohara, D., Takeuchi, Y., Watanabe, H., Lee, Y., Mukoyama, H., Ohteki, T., Kondoh, G., & Hirota, K. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20230923 · Cited by 13
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Zhou, P., Zheng, T., Li, Y., Zhang, X., Feng, J., Wei, Y., Wang, H., Yao, Y., Gong, F., Tian, W., et al. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c03758 · Cited by 12
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Snyder, L. M., McDaniel, K. L., Tian, Y., Wei, C.-H., Kennett, M. J., Patterson, A. D., Ross, A. C., & Cantorna, M. T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03090 · Cited by 12
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Roy, S., & Awasthi, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-16073-9_3 · Cited by 14
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Huang, Y., Zhu, L., Cheng, S., Dai, R., Huang, C., Song, Y., Peng, B., Li, X., Wen, J., Gong, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41319-1 · Cited by 11
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Gu, Y., & Wu, C. (2025) · Mucosal Immunology · doi:10.1016/j.mucimm.2025.12.001 · Cited by 11
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Clark, P. A., Gogoi, M., Rodríguez‐Rodríguez, N., Ferreira, A. C. F., Murphy, J. E., Walker, J. A., Crisp, A., Jolin, H. E., Shields, J. D., & McKenzie, A. N. J. (2024) · Nature Communications · doi:10.1038/s41467-024-52155-2 · Cited by 10
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Yao, X., Ma, K., Zhu, Y., & Cao, S. “. (2025) · Cells · doi:10.3390/cells14110825 · Cited by 10
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Deconstructing deployment of the innate immune lymphocyte army for barrier homeostasis and protection
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Das, A., Ding, Y., Harly, C., & Bhandoola, A. (2026) · Nature Immunology · doi:10.1038/s41590-025-02414-1 · Cited by 9
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Sutherland, D. B., & Fagarasan, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.003 · Cited by 9
The role of innate lymphoid cells in selected disease states – cancer formation, metabolic disorder and inflammation
Poniewierska-Baran, A., Tokarz–Deptuła, B., & Deptuła, W. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.89835 · Cited by 10
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Zheng, M., Tian, Q., Shen, J., & Li, S. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025192 · Cited by 11
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Jackson-Jones, L. H., Cook, P. C., Ivens, A. C., Graham, D. T., Phythian‐Adams, A., Allen, J. E., & MacDonald, A. S. (2015) · International Immunology · doi:10.1093/intimm/dxv020 · Cited by 8
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Wang, X., Darcy, J., Cai, C., Jin, J., Bartke, A., & Cao, D. (2018) · Aging · doi:10.18632/aging.101393 · Cited by 8
Innate lymphoid cells—key immune integrators of overall body homeostasis
Karagiannis, F., & Wilhelm, C. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0684-y · Cited by 9
Self-citation
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Murr, N. J., Olender, T. B., Smith-Oliver, M. R., Smith, A. S., Pilotos, J., Richard, L. B., Mowa, C. N., & Opata, M. M. (2021) · Nutrients · doi:10.3390/nu13030913 · Cited by 7
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Valente, A. H., Jensen, K. M. R., Myhill, L. J., Zhu, L., Mentzel, C. M. J., Krych, Ł., Simonsen, H. T., Castro-Mejía, J. L., Gobbi, A., Knudsen, K. E. B., et al. (2023) · BMC Biology · doi:10.1186/s12915-023-01640-z · Cited by 7
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Xavier‐Elsas, P., Vieira, B. M., Masid‐de‐Brito, D., Barradas, M., & Elsas, M. (2018) · Current Drug Targets · doi:10.2174/1389450120666181217095323 · Cited by 6
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Das, A., Harly, C., Ding, Y., & Bhandoola, A. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-981-16-8387-9_2 · Cited by 7
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Jia, J., Li, J., Guo, J. P., Wang, A., Yan, C., Ren, X., & Xia, X. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.104865 · Cited by 6
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Lee, M., Ko, H., Hong, S., Park, J., Ham, S., Kim, M., Kwon, D.-I., Lee, M.-S., Roh, T., Kim, K. S., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11466-4 · Cited by 6
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Walker, M., Talley, N., & Keely, S. (2019) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2019.1596025 · Cited by 6
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Surace, L., & Santo, J. P. D. (2022) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000722 · Cited by 6
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El-Zayat, S. R., Sibaii, H., Mahfouz, N. N., Sallam, S. F., Fahmy, R., & El-Shaheed, A. A. (2017) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2017.10.007 · Cited by 6
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Kugelberg, E. (2014) · Nature reviews. Immunology · doi:10.1038/nri3626 · Cited by 6
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Min, K. Y., Kim, D., Jo, M. G., Choi, M. Y., Lee, D., Park, J. W., Park, Y.-J., Chung, Y., Kim, Y. M., Park, Y., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01187-1 · Cited by 5
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Dey, P., Mukherjee, S. K., & Parai, D. (2023) · Springer eBooks · doi:10.1007/978-981-99-1463-0_6 · Cited by 6
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Samanta, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821232-5.00011-2 · Cited by 5
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Asahi, T., Abe, S., Tajika, Y., Rodewald, H.-R., Sexl, V., Takeshima, H., & Ikuta, K. (2022) · International Immunology · doi:10.1093/intimm/dxac057 · Cited by 5
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Ruiz‐Sánchez, B. P., Cruz‐Zárate, D., Estrada‐García, I., & Wong‐Baeza, I. (2017) · Revista Alergia México · doi:10.29262/ram.v64i3.284 · Cited by 5
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Hao, J., & Guo, X. (2025) · Trends in Immunology · doi:10.1016/j.it.2025.11.008 · Cited by 5
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Scott, M. E., & Koski, K. G. (2020) · Springer eBooks · doi:10.1007/978-3-030-56913-6_12 · Cited by 7
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Xu, G. B., Pan, Y., Mei, W., & Chen, H. (2023) · Biomedicines · doi:10.3390/biomedicines11102734 · Cited by 4
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Eberl, G. (2014) · Nature · doi:10.1038/nature13216 · Cited by 4
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Maleki, A., Khanmiri, J. M., Khani-Eshratabadi, M., Soveyzi, F., Moazzami, B., Hamblin, M. R., & Rezaei, N. (2020) · European Cytokine Network · doi:10.1684/ecn.2020.0460 · Cited by 4
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Wagage, S., & Hunter, C. A. (2014) · Current Immunology Reviews · doi:10.2174/1573395510666141105234917 · Cited by 4
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Florsheim, E. B., Bachtel, N. D., Cullen, J. L., Lima, B. C., Godazgar, M., Zhang, C., Carvalho, F., Gautier, G., Launay, P., Wang, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.19.524823 · Cited by 4
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Ng, S. S., & Engwerda, C. R. (2018) · Trends in Parasitology · doi:10.1016/j.pt.2018.11.012 · Cited by 2
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Akimbekov, N. S., Digel, I., & Razzaque, M. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00043-7 · Cited by 2
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Li, Q., Li, Y., Zhang, B., Zhai, Y., Lu, W., Cheng, G., & Zhao, Z. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.07.005 · Cited by 2
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Kim, H. Y. (2014) · Allergy Asthma & Respiratory Disease · doi:10.4168/aard.2014.2.5.317 · Cited by 2
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Longman, R., Metz, M. L., & Artis, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811924-2.00014-6 · Cited by 2
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Jung, D. K., Tan, S. T., Hemlock, C., Mertens, A., Stewart, C. P., Rahman, M. Z., Ali, S., Raqib, R., Grembi, J. A., Karim, M. R., et al. (2023) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2023.101969 · Cited by 2
The close association of micronutrients with COVID-19
Zhang, A., Yin, Y., Tian, J., Wang, X., Yue, Z., Pei, L., Liu, L., Li, Q., Jia, M., Wang, H., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28629 · Cited by 2
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Theodorou, M. R., Yu, J., Nikolka, F., Zurkovic, J., Wientjens, C., Weiss, P., Rombo, R., Karagiannis, F., Thiele, C., Hasenauer, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.26.586766 · Cited by 2
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Misal, P., Verma, S., Singh, A. K., & Kar, S. K. (2024) · Integrated science · doi:10.1007/978-3-031-73061-0_19 · Cited by 1
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Tao, H., Geng, J., Bai, L., Su, D., Zhao, Y., Xu, G., & Zhang, M. (2025) · Journal of Molecular Medicine · doi:10.1007/s00109-025-02530-3 · Cited by 1
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Guendel, F., & Lécuyer, E. (2025) · European Journal of Immunology · doi:10.1002/eji.70088 · Cited by 1
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Towers, B. E., & Sonnenberg, G. F. (2025) · International Immunology · doi:10.1093/intimm/dxaf071 · Cited by 1
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Ma, H., Chen, Y., Wang, Y., Zhang, X., Li, J.-N., Wang, Y.-M., & Zhou, Z. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i45.112926 · Cited by 2
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Wu, H., Wang, Y., Tian, Y., Feng, S., Yang, X., Yuan, X., Fan, L., Feng, Q., Liu, Z., & Zhao, Q. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1862570 · Cited by 1
Influence of diet on gastrointestinal immunology
Das, D., Biswas, N., & Mandal, L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821232-5.00002-1 · Cited by 1
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Baker, S. S. (2014) · PEDIATRICS · doi:10.1542/peds.2014-0883 · Cited by 1
Immune modulation by cow’s milk components : Implications for respiratory health
Perdijk, O. (2018) · doi:10.18174/457213 · Cited by 1
Investigação do microbioma intestinal em camundongos deficientes em CRAMP submetidos à sepse experimental
de Almeida, M. L. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2019.tde-16042019-141828 · Cited by 1
Retinoic Acid and Immunity
Larangé, A. (2017) · Wiley eBooks · doi:10.1002/9780470015902.a0027294 · Cited by 1
Loss of Paneth cells dysregulates gut ILC subsets and enhances weight gain response to high fat diet in a mouse modelPreprint
Joldrichsen, M. R., Kim, E., Steiner, H. E., Jeong, Y. J., Premanandan, C., Hsueh, W. A., Ziouzenkova, O., Cormet‐Boyaka, E., & Boyaka, P. N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.29.587349 · Cited by 1
Receptor for advanced glycation endproducts mediates allergic airway inflammation via group 2 innate lymphoid cells
Oczypok, E. A. (2015) · D-Scholarship@Pitt (University of Pittsburgh)
Vitamin B9 and ATP in the control and development of intestinal inflammation
Kunisawa, J. (2015) · Inflammation and Regeneration · doi:10.2492/inflammregen.35.014
Inflammation and Antimicrobial Defense in the Intestine
Caballero, S., & Pamer, E. G. (2015)
Spatial and temporal regulation of cytokine expression in Type 2 immune responses
Kyle, R. L. (2015) · doi:10.26686/wgtn.17013620.v1
Investigating the role of innate lymphoid cells in secondary lymphoid tissue
Mackley, E. C. (2016) · University of Birmingham Institutional Research Archive (University of Birmingham)

Authors: Spencer, S. P., Wilhelm, C., Yang, Q., Hall, J. A., Bouladoux, N., Boyd, A., Nutman, T. B., Urban, J. F., Wang, J., Ramalingam, T. R., Bhandoola, A., Wynn, T. A., & Belkaid, Y.
Affiliations: National Institutes of Health (US)
University of Pennsylvania (US)
Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, NIH, Bethesda, MD 20892, USA.
Beltsville Human Nutrition Research Center (US)
University of California, Berkeley (US)
Corresponding author: Spencer, S. P.
Wilhelm, C.
Belkaid, Y.
ORCID: Spencer, S. P.
Wilhelm, C.
Yang, Q.
Bouladoux, N.
Urban, J. F.
Bhandoola, A.
Wynn, T. A.
Belkaid, Y.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2014-01-24
Volume: 343
Issue: 6169
Pages: 432-437
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1247606
PMC: PMC4313730
OpenAlex: W1999696784
Cited by: 447
References: 38
Citations by year: 2026: 14 · 2025: 23 · 2024: 25 · 2023: 31 · 2022: 33 · 2021: 24 · 2020: 29 · 2019: 44 · 2018: 36 · 2017: 43 · 2016: 40 · 2015: 56 · 2014: 48
FWCI: 28.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (Z99 AI999999)
National Institute of Diabetes and Digestive and Kidney Diseases (F30DK094708)
Topics: Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: innate lymphoid cells, vitamin A deficiency, micronutrient deficiency, malnutrition, Th2 immune response, ILC3, ILC2, IL-13, intestinal immunity, barrier immunity, nematode infection, acute bacterial infection, immune adaptation
MeSH terms: Animals, Enterobacteriaceae Infections, Immunity, Innate, Lymphocytes, Mice, Inbred C57BL, Mice, Mutant Strains, Vitamin A, Vitamin A Deficiency, Homeodomain Proteins, Interleukin-13, Micronutrients, Citrobacter rodentium, Mice, Adaptive Immunity

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Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

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