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Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity
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How the immune system adapts to malnutrition to sustain immunity at barrier surfaces, such as the intestine, remains unclear. Vitamin A deficiency is one of the most common micronutrient deficiencies and is associated with profound defects in adaptive immunity. Here, we found that type 3 innate lymphoid cells (ILC3s) are severely diminished in vitamin A–deficient settings, which results in compromised immunity to acute bacterial infection. However, vitamin A deprivation paradoxically resulted in dramatic expansion of interleukin-13 (IL-13)–producing ILC2s and resistance to nematode infection in mice, which revealed that ILCs are primary sensors of dietary stress. Further, these data indicate that, during malnutrition, a switch to innate type 2 immunity may represent a powerful adaptation of the immune system to promote host survival in the face of ongoing barrier challenges.
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“the depletion of vitamin A, in the adult, led to a decrease of Th1, Th17, and ILC3 responses (a synonym of lowered immunity to bacterial infection), an effect which is counteracted through time127.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [127]
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Cites
Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358
Innate lymphoid cells — a proposal for uniform nomenclature
Spits, H., Artis, D., Colonna, M., Diefenbach, A., Disanto, J. D., Eberl, G., Koyasu, S., Locksley, R., McKenzie, A., Mebius, R., et al. (2013) · Nature reviews. Immunology · doi:10.1038/nri3365 · Cited by 2,380
Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880
Self-citationMucin dynamics and enteric pathogens
McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428
Malnutrition and Infection: Complex Mechanisms and Global Impacts
Schaible, U. E., & Kaufmann, S. H. E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040115 · Cited by 991
Wynn, T. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141142 · Cited by 991
Self-citationThe Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells
Qiu, J., Heller, J. J., Guo, X., Chen, Z. E., Fish, K., Fu, Y., & Zhou, L. (2011) · Immunity · doi:10.1016/j.immuni.2011.11.011 · Cited by 889
The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells
Hoyler, T., Klose, C. S. N., Souabni, A., Turqueti‐Neves, A., Pfeifer, D., Rawlins, E. L., Voehringer, D., Busslinger, M., & Diefenbach, A. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.020 · Cited by 873
Spits, H., & Santo, J. P. D. (2010) · Nature Immunology · doi:10.1038/ni.1962 · Cited by 840
Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation
Li, Y., Innocentin, S., Withers, D. R., Roberts, N. A., Gallagher, A., Grigorieva, E. F., Wilhelm, C., & Veldhoen, M. (2011) · Cell · doi:10.1016/j.cell.2011.09.025 · Cited by 837
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Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology · doi:10.1038/ni.3123 · Cited by 2,160
Innate Lymphoid Cells: 10 Years On
Vivier, É., Artis, D., Colonna, M., Diefenbach, A., Santo, J. P. D., Eberl, G., Koyasu, S., Locksley, R. M., McKenzie, A. N. J., Mebius, R. E., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.017 · Cited by 2,136
Regional specialization within the intestinal immune system
Mowat, A. M., & Agace, W. W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3738 · Cited by 1,882
The biology of innate lymphoid cells
Artis, D., & Spits, H. (2015) · Nature · doi:10.1038/nature14189 · Cited by 1,691
T cell metabolism drives immunity
Buck, M. D., O’Sullivan, D., & Pearce, E. L. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20151159 · Cited by 1,238
Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis
Klose, C. S. N., & Artis, D. (2016) · Nature Immunology · doi:10.1038/ni.3489 · Cited by 954
Interleukin-22: Immunobiology and Pathology
Dudakov, J. A., Hanash, A. M., & van den Brink, M. R. M. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112123 · Cited by 939
Okabe, Y., & Medzhitov, R. (2014) · Cell · doi:10.1016/j.cell.2014.04.016 · Cited by 884
Innate lymphoid cells: A new paradigm in immunology
Eberl, G., Colonna, M., Di Santo, J. P., & McKenzie, A. N. J. (2015) · Science · doi:10.1126/science.aaa6566 · Cited by 878
The microbiota regulates type 2 immunity through RORγt + T cells
Ohnmacht, C., Park, J.-H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., et al. (2015) · Science · doi:10.1126/science.aac4263 · Cited by 863
Commensal–dendritic-cell interaction specifies a unique protective skin immune signature
Naik, S., Bouladoux, N., Linehan, J. L., Han, S.-J., Harrison, O. J., Wilhelm, C., Conlan, S., Himmelfarb, S., Byrd, A. L., Deming, C., et al. (2015) · Nature · doi:10.1038/nature14052 · Cited by 820
Self-citationImmune Dysfunction as a Cause and Consequence of Malnutrition
Bourke, C. D., Berkley, J. A., & Prendergast, A. J. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.04.003 · Cited by 771
Robinette, M. L., Fuchs, A. G., Cortez, V. S., Lee, J. S., Wang, Y., Durum, S. K., Gilfillan, S., & Colonna, M. (2015) · Nature Immunology · doi:10.1038/ni.3094 · Cited by 662
Bernink, J. H., Krabbendam, L., Germar, K., de Jong, E. C., Gronke, K., Kofoed-Nielsen, M., Munneke, J. M., Hazenberg, M. D., Villaudy, J., Buskens, C. J., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.019 · Cited by 609
Role of Vitamin A in the Immune System
Huang, Z., Liu, Y., Qi, G., Brand, D., & Zheng, S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090258 · Cited by 597
Gury-BenAri, M., Thaiss, C. A., Serafini, N., Winter, D. R., Giladi, A., Lara-Astiaso, D., Levy, M., Salame, T. M., Weiner, A., David, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.043 · Cited by 587
Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
Cardoso, V., Chesné, J., Ribeiro, H., García-Cassani, B., Carvalho, T., Bouchery, T., Shah, K., Barbosa-Morais, N. L., Harris, N., & Veiga-Fernandes, H. (2017) · Nature · doi:10.1038/nature23469 · Cited by 592
Development, Differentiation, and Diversity of Innate Lymphoid Cells
Diefenbach, A., Colonna, M., & Koyasu, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.005 · Cited by 560
Innate lymphoid cells in the initiation, regulation and resolution of inflammation
Sonnenberg, G. F., & Artis, D. (2015) · Nature Medicine · doi:10.1038/nm.3892 · Cited by 503
Metabolites: messengers between the microbiota and the immune systemPreprint
Levy, M., Thaiss, C. A., & Elinav, E. (2016) · Genes & Development · doi:10.1101/gad.284091.116 · Cited by 449
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity
van de Pavert, S. A., Ferreira, M., Domingues, R. G., Ribeiro, H., Molenaar, R., Moreira-Santos, L., Almeida, F. F., Ibiza, S., Barbosa, I., Goverse, G., et al. (2014) · Nature · doi:10.1038/nature13158 · Cited by 374
Innate lymphoid cells: major players in inflammatory diseases
Ebbo, M., Crinier, A., Vely, F., & Vivier, É. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.86 · Cited by 371
Innate Lymphoid Cells in Inflammation and Immunity
McKenzie, A. N. J., Spits, H., & Eberl, G. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.006 · Cited by 384
Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
Ibiza, S., García-Cassani, B., Ribeiro, H., Carvalho, T., Almeida, L., Marques, R., Misic, A. M., Bartow‐McKenney, C., Larson, D. M., Pavan, W. J., et al. (2016) · Nature · doi:10.1038/nature18644 · Cited by 375
Hallmarks of Tissue-Resident Lymphocytes
Fan, X., & Rudensky, A. Y. (2016) · Cell · doi:10.1016/j.cell.2016.02.048 · Cited by 368
Impact of Childhood Malnutrition on Host Defense and Infection
Ibrahim, M. K., Zambruni, M., Melby, C. L., & Melby, P. C. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00119-16 · Cited by 382
IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches
Reboldi, A., Arnon, T. I., Rodda, L. B., Atakilit, A., Sheppard, D., & Cyster, J. G. (2016) · Science · doi:10.1126/science.aaf4822 · Cited by 345
Type 2 immunity: Expanding our view
Lloyd, C. M., & Snelgrove, R. J. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat1604 · Cited by 338
Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases
Jiao, Y., Wu, L., Huntington, N. D., & Zhang, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00282 · Cited by 321
Ciccia, F., Guggino, G., Rizzo, A. G., Saieva, L., Peralta, S., Giardina, A. R., Cannizzaro, A., Sireci, G., Leo, G. D., Alessandro, R., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-206323 · Cited by 313
The Influence of Dietary Fatty Acids on Immune Responses
Radzikowska, U., Rinaldi, A. O., Çelebi Sözener, Z., Karaguzel, D., Wojcik, M., Cypryk, K., Akdis, M., Akdis, C. A., & Sokolowska, M. (2019) · Nutrients · doi:10.3390/nu11122990 · Cited by 306
The group 2 innate lymphoid cell ( ILC 2) regulatory network and its underlying mechanisms
Kabata, H., Moro, K., & Koyasu, S. (2018) · Immunological Reviews · doi:10.1111/imr.12706 · Cited by 295
Transcriptional regulation of innate lymphoid cell fate
Serafini, N., Vosshenrich, C. A. J., & Santo, J. P. D. (2015) · Nature reviews. Immunology · doi:10.1038/nri3855 · Cited by 309
Xu, H., Ding, J., Porter, C. B. M., Wallrapp, A., Tabaka, M., Ma, S., Fu, S., Guo, X., Riesenfeld, S. J., Su, C., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.004 · Cited by 273
Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin
Kim, B., Wang, K., Siracusa, M. C., Saenz, S. A., Brestoff, J. R., Monticelli, L. A., Noti, M., Wojno, E. D. T., Fung, T. C., Kubo, M., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401307 · Cited by 278
ILC3 function as a double-edged sword in inflammatory bowel diseases
Zeng, B., Shi, S., Ashworth, G., Dong, C., Liu, J., & Xing, F. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1540-2 · Cited by 290
Metabolic control of regulatory T cell development and function
Zeng, H., & Chi, H. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.08.003 · Cited by 282
The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction
Collins, N., Han, S., Enamorado, M., Link, V. M., Huang, B., Moseman, E. A., Kishton, R. J., Shannon, J. P., Dixit, D., Schwab, S. R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.049 · Cited by 273
Self-citationBeyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology
Rankin, L. C., & Artis, D. (2018) · Cell · doi:10.1016/j.cell.2018.03.013 · Cited by 275
The impact of diet on asthma and allergic diseases
Julia, V., Macia, L., & Dombrowicz, D. (2015) · Nature reviews. Immunology · doi:10.1038/nri3830 · Cited by 265
Environmental Enteric Dysfunction: An Overview
Crane, R. J., Jones, K. D. J., & Berkley, J. A. (2015) · Food and Nutrition Bulletin · doi:10.1177/15648265150361s113 · Cited by 254
Rivas, M. N., Burton, O. T., Oettgen, H. C., & Chatila, T. A. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.02.030 · Cited by 250
Microbiota-mediated inflammation and antimicrobial defense in the intestine
Caballero, S., & Pamer, E. G. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120238 · Cited by 238
Yu, X., Wang, Y., Deng, M., Li, Y., Ruhn, K. A., Zhang, C. C., & Hooper, L. V. (2014) · eLife · doi:10.7554/elife.04406 · Cited by 244
Cantorna, M. T., Snyder, L. M., & Arora, J. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1611734 · Cited by 244
The role of airway epithelial cells and innate immune cells in chronic respiratory disease
Holtzman, M. J., Byers, D. E., Alexander‐Brett, J. M., & Wang, X. (2014) · Nature reviews. Immunology · doi:10.1038/nri3739 · Cited by 246
Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System
Larangé, A., & Cheroutre, H. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055427 · Cited by 243
Retinoic Acid Differentially Regulates the Migration of Innate Lymphoid Cell Subsets to the Gut
Kim, M. H., Taparowsky, E. J., & Kim, C. H. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.009 · Cited by 235
Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis
Trabanelli, S., Chevalier, M. F., Martínez-Usatorre, A., Gomez‐Cadena, A., Salomé, B., Lecciso, M., Salvestrini, V., Verdeil, G., Racle, J., Papayannidis, C., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00678-2 · Cited by 234
The interplay between the gut microbiota and the immune system
Geuking, M. B., Köller, Y., Rupp, S., & McCoy, K. D. (2014) · Gut Microbes · doi:10.4161/gmic.29330 · Cited by 239
Skin-resident innate lymphoid cells converge on a pathogenic effector state
Bielecki, P., Riesenfeld, S. J., Hütter, J.-C., Triglia, E. T., Kowalczyk, M. S., Ricardo-González, R. R., Lian, M., Vesely, M. C. A., Kroehling, L., Xu, H. Y., et al. (2021) · Nature · doi:10.1038/s41586-021-03188-w · Cited by 223
ILC2-modulated T cell–to-MDSC balance is associated with bladder cancer recurrence
Chevalier, M. F., Trabanelli, S., Racle, J., Salomé, B., Cesson, V., Gharbi, D., Bohner, P., Domingos‐Pereira, S., Dartiguenave, F., Fritschi, A.-S., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89717 · Cited by 218
The multifaceted immune regulation of bladder cancer
Schneider, A. K., Chevalier, M. F., & Derré, L. (2019) · Nature Reviews Urology · doi:10.1038/s41585-019-0226-y · Cited by 222
Mackley, E. C., Houston, S. A., Marriott, C. L., Halford, E. E., Lucas, B., Cerovic, V., Filbey, K. J., Maizels, R. M., Hepworth, M. R., Sonnenberg, G. F., et al. (2015) · Nature Communications · doi:10.1038/ncomms6862 · Cited by 214
Immunity to Helminths: Resistance, Regulation, and Susceptibility to Gastrointestinal Nematodes
Grencis, R. K. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120218 · Cited by 211
Wilhelm, C., Harrison, O. J., Schmitt, V., Pelletier, M., Spencer, S. P., Urban, J. F., Ploch, M., Ramalingam, T. R., Siegel, R. M., & Belkaid, Y. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151448 · Cited by 215
Self-citationGoverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M. N., Konijn, T., Knippenberg, M., Cook, E. C. L., Hanekamp, D., Veldhoen, M., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600165 · Cited by 200
Functional and phenotypic heterogeneity of group 3 innate lymphoid cells
Melo-González, F., & Hepworth, M. R. (2016) · Immunology · doi:10.1111/imm.12697 · Cited by 207
The cross talk between microbiota and the immune system: metabolites take center stage
Shapiro, H., Thaiss, C. A., Levy, M., & Elinav, E. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.07.003 · Cited by 189
Seehus, C. R., Aliahmad, P., de la Torre, B., Iliev, I. D., Spurka, L., Funari, V. A., & Kaye, J. G. (2015) · Nature Immunology · doi:10.1038/ni.3168 · Cited by 192
Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity
Klose, C. S. N., & Artis, D. (2020) · Cell Research · doi:10.1038/s41422-020-0323-8 · Cited by 206
Group 3 innate lymphoid cells (ILC3s): Origin, differentiation, and plasticity in humans and mice
Montaldo, E., Juelke, K., & Romagnani, C. (2015) · European Journal of Immunology · doi:10.1002/eji.201545598 · Cited by 199
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Xu, W., Domingues, R. G., Fonseca‐Pereira, D., Ferreira, M. M., Ribeiro, H., Lopez‐Lastra, S., Motomura, Y., Moreira-Santos, L., Bihl, F., Braud, V. M., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.057 · Cited by 184
Migration and Tissue Tropism of Innate Lymphoid Cells
Kim, C. H., Hashimoto‐Hill, S., & Kim, M. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.11.003 · Cited by 188
Innate Lymphoid Cell Development: A T Cell Perspective
Cherrier, D. E., Serafini, N., & Di Santo, J. P. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.010 · Cited by 181
Morita, H., Kubo, T., Rückert, B., Ravindran, A., Soyka, M., Rinaldi, A. O., Sugita, K., Wawrzyniak, M., Wawrzyniak, P., Motomura, K., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.12.1018 · Cited by 179
γδ T cells regulate the intestinal response to nutrient sensing
Sullivan, Z. A., Khoury-Hanold, W., Lim, J., Smillie, C. S., Biton, M., Reis, B. S., Zwick, R. K., Pope, S. D., Israni-Winger, K., Parsa, R., et al. (2021) · Science · doi:10.1126/science.aba8310 · Cited by 162
Transcriptional Regulation of Innate and Adaptive Lymphocyte Lineages
Obaldia, M. E. D., & Bhandoola, A. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112032 · Cited by 167
Self-citationDietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation
Lewis, G., Wang, B., Shafiei Jahani, P., Hurrell, B. P., Banie, H., Aleman Muench, G. R., Maazi, H., Helou, D. G., Howard, E., Galle-Treger, L., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02051 · Cited by 163
Ishizuka, I. E., Chea, S., Gudjonson, H., Constantinides, M. G., Dinner, A. R., Bendelac, A. S., & Golub, R. (2016) · Nature Immunology · doi:10.1038/ni.3344 · Cited by 162
Kløverpris, H. N., Kazer, S. W., Mjösberg, J., Mabuka, J. M., Wellmann, A. L., Ndhlovu, Z. M., Yadon, M., Nhamoyebonde, S., Muenchhoff, M., Simoni, Y., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.006 · Cited by 158
Carotenoid metabolism at the intestinal barrier
Lintig, J. V., Moon, J., Lee, J., & Ramkumar, S. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158580 · Cited by 161
Immune sensing of food allergens promotes avoidance behaviour
Florsheim, E. B., Bachtel, N. D., Cullen, J. L., Lima, B. C., Godazgar, M., Carvalho, F., Chatain, C. P., Zimmer, M. R., Zhang, C., Gautier, G., et al. (2023) · Nature · doi:10.1038/s41586-023-06362-4 · Cited by 160
Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection
Derebe, M. G., Zlatkov, C. M., Gattu, S., Ruhn, K. A., Vaishnava, S., Diehl, G. E., MacMillan, J. B., Williams, N. S., & Hooper, L. V. (2014) · eLife · doi:10.7554/elife.03206 · Cited by 147
Influence of the microbiota on vaccine effectiveness
Valdez, Y., Brown, E., & Finlay, B. B. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.07.003 · Cited by 147
IL-2 is a critical regulator of group 2 innate lymphoid cell function during pulmonary inflammation
Roediger, B., Kyle, R. L., Tay, S. S., Mitchell, A. J., Bolton, H. A., Guy, T. V., Tan, S., Forbes‐Blom, E., Tong, P. L., Köller, Y., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.03.043 · Cited by 146
Brown, C. C., Esterházy, D., Sarde, A., London, M., Pullabhatla, V., Osma-García, I. C., al-Bader, R., Ortiz, C., Elgueta, R., Arno, M. J., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.003 · Cited by 147
Neuroimmune regulation during intestinal development and homeostasis
Veiga‐Fernandes, H., & Pachnis, V. (2017) · Nature Immunology · doi:10.1038/ni.3634 · Cited by 146
Retinoic Acid as a Modulator of T Cell Immunity
Bono, M., Tejon, G., Flores-Santibañez, F., Fernandez, D., Rosemblatt, M., & Sauma, D. (2016) · Nutrients · doi:10.3390/nu8060349 · Cited by 143
Cells of the innate and adaptive immunity and their interactions in inflammatory bowel disease
Kmieć, Z., Cyman, M., & Ślebioda, T. J. (2017) · Advances in Medical Sciences · doi:10.1016/j.advms.2016.09.001 · Cited by 151
Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine
Ferreira, R., Napoli, J., Enver, T., Bernardino, L., & Ferreira, L. (2020) · Nature Communications · doi:10.1038/s41467-020-18042-2 · Cited by 138
Type-2 Innate Lymphoid Cells in Asthma and Allergy
McKenzie, A. N. J. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201403-097aw · Cited by 136
Roles and Regulation of Gastrointestinal Eosinophils in Immunity and Disease
Jung, Y., & Rothenberg, M. E. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400413 · Cited by 137
Distal Consequences of Oral Inflammation
Konkel, J. E., O’Boyle, C., & Krishnan, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01403 · Cited by 144
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease
Basson, A. R., Trotter, A., Rodriguez‐Palacios, A., & Cominelli, F. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00290 · Cited by 140
Control of immunity via nutritional interventions
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Metadata
- Authors
- Spencer, S. P., Wilhelm, C., Yang, Q., Hall, J. A., Bouladoux, N., Boyd, A., Nutman, T. B., Urban, J. F., Wang, J., Ramalingam, T. R., Bhandoola, A., Wynn, T. A., & Belkaid, Y.
- Affiliations
- National Institutes of Health (US)
- University of Pennsylvania (US)
- Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, NIH, Bethesda, MD 20892, USA.
- Beltsville Human Nutrition Research Center (US)
- University of California, Berkeley (US)
- Corresponding author
- Spencer, S. P.
- Wilhelm, C.
- Belkaid, Y.
- Venue
- Science
- Published
- 2014-01-24
- Volume
- 343
- Issue
- 6169
- Pages
- 432-437
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4313730
- OpenAlex
- W1999696784
- Cited by
- 447
- References
- 38
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 25 · 2023: 31 · 2022: 33 · 2021: 24 · 2020: 29 · 2019: 44 · 2018: 36 · 2017: 43 · 2016: 40 · 2015: 56 · 2014: 48
- FWCI
- 28.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 AI999999)
- National Institute of Diabetes and Digestive and Kidney Diseases (F30DK094708)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- innate lymphoid cells, vitamin A deficiency, micronutrient deficiency, malnutrition, Th2 immune response, ILC3, ILC2, IL-13, intestinal immunity, barrier immunity, nematode infection, acute bacterial infection, immune adaptation
- MeSH terms
- Animals, Enterobacteriaceae Infections, Immunity, Innate, Lymphocytes, Mice, Inbred C57BL, Mice, Mutant Strains, Vitamin A, Vitamin A Deficiency, Homeodomain Proteins, Interleukin-13, Micronutrients, Citrobacter rodentium, Mice, Adaptive Immunity
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