Optical Control of Muscle Function by Transplantation of Stem Cell–Derived Motor Neurons in Mice

Efficient selection for high-expression transfectants with a novel eukaryotic vector

Niwa, H., Yamamura, K., & Miyazaki, J. (1991) · Gene · doi:10.1016/0378-1119(91)90434-d · Cited by 5,135 · see citing works

Millisecond-timescale, genetically targeted optical control of neural activity

Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,831 · see citing works

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

Nagel, G., Szellas, T., Huhn, W., Kateriya, S., Adeishvili, N., Berthold, P. R., Ollig, D., Hegemann, P., & Bamberg, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1936192100 · Cited by 2,672 · see citing works

Directed differentiation of embryonic stem cells into motor neurons.

Wichterle, H., Lieberam, I., Porter, J. A., & Jessell, T. (2002) · Cell · doi:10.1016/s0092-8674(02)00835-8 · Cited by 1,792 · see citing works

Relation between size of neurons and their susceptibility to discharge

Henneman, E. (1957) · Science · doi:10.1126/science.126.3287.1345 · Cited by 1,227 · see citing works

Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS

Filbin, M. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1195 · Cited by 873 · see citing works

ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation

Lin, J. Y., Knutsen, P. M., Muller, A., Kleinfeld, D., & Tsien, R. Y. (2013) · Nature Neuroscience · doi:10.1038/nn.3502 · Cited by 837 · see citing works

GFAP promoter directs astrocyte-specific expression in transgenic mice

Brenner, M., Kisseberth, W., Su, Y., Besnard, F., & Messing, A. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01030.1994 · Cited by 485 · see citing works

A Generic Intron Increases Gene Expression in Transgenic Mice

Choi, T., Huang, M. T. F., Gorman, C., & Jaenisch, R. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.6.3070 · Cited by 356 · see citing works

Activation of flavin-containing oxidases underlies light-induced production of H 2 O 2 in mammalian cells

Hockberger, P. E., Skimina, T. A., Centonze, V. E., Lavin, C., Chu, S., Dadras, S. S., Reddy, J. K., & White, J. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6255 · Cited by 320 · see citing works

p107 is a suppressor of retinoblastoma development in pRb-deficient micePreprint

Robanus-Maandag, E. C., Dekker, M., van der Valk, M., Carrozza, M. L., Jeanny, J., Dannenberg, J., Berns, A. J. M., & Riele, H. T. (1998) · Genes & Development · doi:10.1101/gad.12.11.1599 · Cited by 319 · see citing works

Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats

Harper, J. M., Krishnan, C., Darman, J., Deshpande, D. M., Peck, S., Shats, I., Backovic, S., Rothstein, J. D., & Kerr, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401103101 · Cited by 234 · see citing works

Orderly recruitment of motor units under optical control in vivo

Llewellyn, M. E., Thompson, K. R., Deisseroth, K., & Delp, S. L. (2010) · Nature Medicine · doi:10.1038/nm.2228 · Cited by 217 · see citing works

Diaphragm pacing by electrical stimulation of the phrenic nerve

Glenn, W. W. L., & Phelps, M. L. (1985) · Neurosurgery · doi:10.1227/00006123-198512000-00021 · Cited by 210 · see citing works

Complete worldwide operative experience in laparoscopic diaphragm pacing: results and differences in spinal cord injured patients and amyotrophic lateral sclerosis patients

Onders, R. P., Elmo, M., Khansarinia, S., Bowman, B., Yee, J., ROAD, J. D., Bass, B. L., Dunkin, B. J., Ingvarsson, P. E., & Oddsdóttir, M. (2008) · Surgical Endoscopy · doi:10.1007/s00464-008-0223-3 · Cited by 170 · see citing works

Transposon-mediated BAC transgenesis in zebrafish and mice

Suster, M. L., Sumiyama, K., & Kawakami, K. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-477 · Cited by 161 · see citing works

Optogenetic Control of Targeted Peripheral Axons in Freely Moving Animals

Towne, C., Montgomery, K. L., Iyer, S. M., Deisseroth, K., & Delp, S. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072691 · Cited by 156 · see citing works

Transposition of the Tol2 Element, an Ac-Like Element From the Japanese Medaka Fish Oryzias latipes, in Mouse Embryonic Stem Cells

Kawakami, K., & Noda, T. (2004) · Genetics · doi:10.1534/genetics.166.2.895 · Cited by 136 · see citing works

Functional Diversity of ESC-Derived Motor Neuron Subtypes Revealed through Intraspinal Transplantation

Peljto, M., Dasen, J. S., Mazzoni, E. O., Jessell, T. M., & Wichterle, H. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.013 · Cited by 132 · see citing works

Activity and synapse elimination at the neuromuscular junction

Thompson, W. J. (1985) · Cellular and Molecular Neurobiology · doi:10.1007/bf00711091 · Cited by 125 · see citing works

A Generic Intron Increases Gene Expression in Transgenic Mice

Choi, T., Huang, M. T. F., Gorman, C. M., et al. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.6.3070-3074.1991 · Cited by 116 · see citing works

Transplanted Mouse Embryonic Stem-Cell-Derived Motoneurons Form Functional Motor Units and Reduce Muscle Atrophy

Yohn, D. C., Miles, G. B., Rafuse, V. F., & Brownstone, R. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1761-08.2008 · Cited by 97 · see citing works

Amyloid precursor protein (APP) contributes to pathology in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Bryson, J. B., Hobbs, C., Parsons, M. J., Bosch, K. D., Pandraud, A., Walsh, F. S., Doherty, P., & Greensmith, L. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds215 · Cited by 72 · see citing works

Changes during the postnatal development in physiological and anatomical characteristics of rat motoneurons studied in vitro

Carrascal, L., Nieto-González, J. L., Cameron, W. E., Torres, B., & Nunez‐Abades, P. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.02.003 · Cited by 64 · see citing works

Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons

Machado, C. B., Kanning, K. C., Kreis, P., Stevenson, D. C., Crossley, M., Nowak, M., Iacovino, M., Kyba, M., Chambers, D. J., Blanc, E., et al. (2014) · Development · doi:10.1242/dev.097188 · Cited by 53 · see citing works

Embryonic Stem Cells for Neural Replacement Therapy: Prospects and Challenges

Zhang, S. (2003) · Stem Cells and Development · doi:10.1089/15258160360732650 · Cited by 36 · see citing works

Optogenetic cell control in experimental models of neurological disorders

Tønnesen, J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.07.007 · Cited by 23 · see citing works

Pain Conduction in the Phrenic Nerve

Gernandt, B. E. (1946) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1946.tb00385.x · Cited by 5 · see citing works

Stretchable organic optoelectronic sensorimotor synapse

Lee, Y., Oh, J. Y., Xu, W., Kim, O., Kim, T. R., Kang, J., Kim, Y., Son, D., Tok, J. B. ‐., Park, M. J., et al. (2018) · Science Advances · doi:10.1126/sciadv.aat7387 · Cited by 536 · see citing works

Electrospinning: An enabling nanotechnology platform for drug delivery and regenerative medicine

Chen, S., Li, R., Li, X., & Xie, J. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.05.001 · Cited by 383 · see citing works

Optogenetic skeletal muscle-powered adaptive biological machines

Raman, R., Cvetkovic, C., Uzel, S. G. M., Platt, R. J., Sengupta, P., Kamm, R. D., & Bashir, R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516139113 · Cited by 347 · see citing works

Modeling ALS with motor neurons derived from human induced pluripotent stem cells

Sances, S., Bruijn, L. I., Chandran, S., Eggan, K., Ho, R., Klim, J. R., Livesey, M. R., Lowry, E., Macklis, J. D., Rushton, D., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4273 · Cited by 289 · see citing works

Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units

Uzel, S. G. M., Platt, R. J., Subramanian, V., Pearl, T. M., Rowlands, C. J., Chan, V., Boyer, L. A., So, P. T. C., & Kamm, R. D. (2016) · Science Advances · doi:10.1126/sciadv.1501429 · Cited by 212 · see citing works

Neuromodulation in the restoration of function after spinal cord injury.

James, N., McMahon, S., Field-Fote, E., & Bradbury, E. (2018) · Lancet Neurology · doi:10.1016/s1474-4422(18)30287-4 · Cited by 140 · see citing works

Towards translational optogenetics

Bansal, A., Shikha, S., & Zhang, Y. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00829-3 · Cited by 173 · see citing works

In Vitro Microfluidic Models for Neurodegenerative Disorders

Osaki, T., Shin, Y., Sivathanu, V., Campisi, M., & Kamm, R. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700489 · Cited by 127 · see citing works

Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system

Montgomery, K. L., Iyer, S. M., Christensen, A. J., Deisseroth, K., & Delp, S. L. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7577 · Cited by 147 · see citing works

Optimal electrical stimulation boosts stem cell therapy in nerve regeneration

Du, J., Zhen, G., Chen, H. A., Zhang, S., Qing, L., Yang, X., Lee, G., Mao, H., & Jia, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.015 · Cited by 147 · see citing works

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Fairbairn, N. G. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i1.11 · Cited by 143 · see citing works

Moving Stem Cells to the Clinic: Potential and Limitations for Brain Repair

Steinbeck, J. A., & Studer, L. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.002 · Cited by 134 · see citing works

Optogenetic control of contractile function in skeletal muscle

Bruegmann, T., Bremen, T. V., Vogt, C. C., Send, T., Fleischmann, B. K., & Sasse, P. (2015) · Nature Communications · doi:10.1038/ncomms8153 · Cited by 132 · see citing works

A bioinspired optoelectronically engineered artificial neurorobotics device with sensorimotor functionalities

Akbari, M. K., & Zhuiykov, S. (2019) · Nature Communications · doi:10.1038/s41467-019-11823-4 · Cited by 132 · see citing works

Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease

Steinbeck, J. A., Jaiswal, M. K., Calder, E. L., Kishinevsky, S., Weishaupt, A., Toyka, K. V., Goldstein, P. A., & Studer, L. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.10.002 · Cited by 127 · see citing works

Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review

Yildiz, K. A., Shin, A. Y., & Kaufman, K. R. (2020) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-020-00667-5 · Cited by 113 · see citing works

Reactivation of Denervated Schwann Cells by Embryonic Spinal Cord Neurons to Promote Axon Regeneration and Remyelination

Fang, X., Zhang, C., Zhang, C., Cai, Y., Yu, Z., Huang, Z., Li, W., & Zhang, W. (2019) · Stem Cells International · doi:10.1155/2019/7378594 · Cited by 106 · see citing works

Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction

Gordon, D., Dafinca, R., Scaber, J., Alegre‐Abarrategui, J., Farrimond, L. E., Scott, C., Biggs, D., Kent, L., Oliver, P. L., Davies, B., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.024 · Cited by 96 · see citing works

Gold Nanoshell-Mediated Remote Myotube Activation

Marino, A., Arai, S., Hou, Y., Degl’Innocenti, A., Cappello, V., Mazzolai, B., Chang, Y., Mattoli, V., Suzuki, M., & Ciofani, G. (2017) · ACS Nano · doi:10.1021/acsnano.6b08202 · Cited by 88 · see citing works

Reconnecting Eye to Brain

Crair, M. C., & Mason, C. A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1711-16.2016 · Cited by 86 · see citing works

Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term Cultures

Lam, R. S., Töpfer, F. M., Wood, P. G., Busskamp, V., & Bamberg, E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169506 · Cited by 79 · see citing works

Optogenetic control of nerve growth

Park, S., Koppes, R. A., Froriep, U. P., Jia, X., Achyuta, A. K. H., McLaughlin, B. L., & Anikeeva, P. (2015) · Scientific Reports · doi:10.1038/srep09669 · Cited by 81 · see citing works

Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis

Ciervo, Y., Ning, K., Xu, J., Shaw, P. J., & Mead, R. J. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0227-3 · Cited by 82 · see citing works

The Evolution of Neuroprosthetic Interfaces

Adewole, D. O., Serruya, M. D., Harris, J. P., Burrell, J. C., Petrov, D., Chen, H.-C. I., Wolf, J. A., & Cullen, D. K. (2016) · Critical Reviews in Biomedical Engineering · doi:10.1615/critrevbiomedeng.2016017198 · Cited by 81 · see citing works

Restoring nervous system structure and function using tissue engineered living scaffolds

Struzyna, L. A., Harris, J. P., Katiyar, K. S., Chen, H., & Cullen, D. K. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.156943 · Cited by 75 · see citing works

The Roles of Optogenetics and Technology in Neurobiology: A Review

Chen, W., Li, C., Liang, W., Li, Y., Zou, Z., Xie, Y., Liao, Y., Lin, Y., Lin, Q., Huang, M., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.867863 · Cited by 71 · see citing works

Living scaffolds for neuroregeneration

Struzyna, L. A., Katiyar, K. S., & Cullen, D. K. (2014) · Current Opinion in Solid State and Materials Science · doi:10.1016/j.cossms.2014.07.004 · Cited by 71 · see citing works

Reconstruction of brain circuitry by neural transplants generated from pluripotent stem cells

Thompson, L. H., & Björklund, A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.04.003 · Cited by 67 · see citing works

Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

Izquierdo-Serra, M., Bautista-Barrufet, A., Trapero, A., Garrido‐Charles, A., Díaz‐Tahoces, A., Camarero, N., Pittolo, S., Valbuena, S., Perez‐Jiménez, A., Gay, M., et al. (2016) · Nature Communications · doi:10.1038/ncomms12221 · Cited by 67 · see citing works

Optogenetics in bacteria – applications and opportunities

Lindner, F., & Diepold, A. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab055 · Cited by 66 · see citing works

Stable InSe transistors with high-field effect mobility for reliable nerve signal sensing

Jiang, J., Li, J., Li, Y., Duan, J., Li, L., Tian, Y., Zong, Z., Zheng, H., Feng, X., Li, Q., et al. (2019) · npj 2D Materials and Applications · doi:10.1038/s41699-019-0110-x · Cited by 63 · see citing works

Neuroprotective potential of astroglia

Liu, B., Teschemacher, A. G., & Kasparov, S. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24140 · Cited by 62 · see citing works

Neurostimulation for Stroke Rehabilitation

Ting, W. K., Fadul, F. A.-R., Fecteau, S., & Éthier, C. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.649459 · Cited by 64 · see citing works

Optogenetics enlightens neuroscience drug discovery

Song, C., & Knöpfel, T. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.15 · Cited by 60 · see citing works

An Artificial Reflex Arc That Perceives Afferent Visual and Tactile Information and Controls Efferent Muscular Actions

Sun, L., Du, Y., Yu, H., Wei, H., Xu, W., & Xu, W. (2022) · Research · doi:10.34133/2022/9851843 · Cited by 61 · see citing works

Targeting phosphoglycerate kinase 1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis

Chaytow, H., Carroll, E., Gordon, D., Huang, Y.-T., van der Hoorn, D., Smith, H. L., Becker, T., Becker, C. G., Faller, K. M. E., Talbot, K., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104202 · Cited by 60 · see citing works

Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy

Magown, P., Shettar, B. C., Zhang, Y., & Rafuse, V. (2015) · Nature Communications · doi:10.1038/ncomms9506 · Cited by 58 · see citing works

Biobased Elastomer Nanofibers Guide Light‐Controlled Human‐iPSC‐Derived Skeletal Myofibers

Cheesbrough, A., Sciscione, F., Riccio, F., Harley, P., R’Bibo, L., Ziakas, G., Darbyshire, A., Lieberam, I., & Song, W. (2022) · Advanced Materials · doi:10.1002/adma.202110441 · Cited by 52 · see citing works

Optogenetic Medicine: Synthetic Therapeutic Solutions Precision-Guided by LightPreprint

Ye, H., & Fussenegger, M. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a034371 · Cited by 53 · see citing works

IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells

Lehnen, D., Barral, S., Cardoso, T., Grealish, S., Heuer, A., Smiyakin, A., Kirkeby, A., Kollet, J., Cremer, H., Parmar, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.08.016 · Cited by 52 · see citing works

Non-viral delivery of an optogenetic tool into cells with self-healing hydrogel

Hsieh, F.-Y., Han, H., Chen, X., Yang, C., Wei, Y., & Hsu, S. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.014 · Cited by 51 · see citing works

In Vitro Modeling of Nerve–Muscle Connectivity in a Compartmentalized Tissue Culture Device

Machado, C. B., Pluchon, P., Harley, P., Rigby, M., Sabater, V. G., Stevenson, D. C., Hynes, S., Lowe, A., Burrone, J., Viasnoff, V., et al. (2019) · Advanced Biosystems · doi:10.1002/adbi.201800307 · Cited by 50 · see citing works

Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease

Bursac, N., Juhas, M. E., & Rando, T. A. (2015) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071114-040640 · Cited by 49 · see citing works

Optically-Induced Neuronal Activity Is Sufficient to Promote Functional Motor Axon Regeneration In Vivo

Ward, P. J., Jones, L. N., Mulligan, A., Goolsby, W. N., Wilhelm, J. C., & ENGLISH, A. W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154243 · Cited by 45 · see citing works

The evolution of nerve transfers for spinal cord injury

Bazarek, S. F., & Brown, J. M. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113426 · Cited by 44 · see citing works

Optogenetic control of insulin secretion by pancreatic β-cells in vitro and in vivo

Kushibiki, T., Okawa, S., Hirasawa, T., & Ishihara, M. (2015) · Gene Therapy · doi:10.1038/gt.2015.23 · Cited by 42 · see citing works

Implantable Micro-Light-Emitting Diode (µLED)-based optogenetic interfaces toward human applications

Lee, J. H., Lee, S., Kim, D., & Lee, K. J. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114399 · Cited by 41 · see citing works

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch

Lin, W., Jia, X., Shi, X., He, Q., Zhang, P., Zhang, X., Zhang, L., Wu, M., Ren, T., Liu, Y., et al. (2025) · Science · doi:10.1126/science.adp0176 · Cited by 39 · see citing works

Optical cuff for optogenetic control of the peripheral nervous system

Michoud, F., Sottas, L., Browne, L. E., Asboth, L., Latrémolière, A., Sakuma, M., Courtine, G., Woolf, C. J., & Lacour, S. P. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa9126 · Cited by 39 · see citing works

Analysis of Signaling Endosome Composition and Dynamics Using SILAC in Embryonic Stem Cell-Derived Neurons

Debaisieux, S., Encheva, V., Chakravarty, P., Snijders, A. P., & Schiavo, G. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.051649 · Cited by 38 · see citing works

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells

Nadadhur, A. G., Emperador-Melero, J., Meijer, M., Schut, D., Jacobs, G., Li, K. W., Hjorth, J. J. J., Meredith, R. M., Toonen, R. F. G., van Kesteren, R. E., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178533 · Cited by 38 · see citing works

Illuminating Parkinson's therapy with optogenetics

Chen, Y., Xiong, M., & Zhang, S. (2015) · Nature Biotechnology · doi:10.1038/nbt.3140 · Cited by 33 · see citing works

Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains

Lei, W., Li, W., Ge, L., & Chen, G. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00131 · Cited by 31 · see citing works

Optogenetic neuronal stimulation promotes axon outgrowth and myelination of motor neurons in a three‐dimensional motor neuron–Schwann cell coculture model on a microfluidic biochip

Hyung, S., Lee, B., Kim, Y. J., Bang, S., Tahk, D., Park, J., Suh, J. F., & Jeon, N. L. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.27083 · Cited by 31 · see citing works

Actuated tissue engineered muscle grafts restore functional mobility after volumetric muscle loss

Rousseau, E. B., Raman, R., Tamir, T. Y., Bu, A., Srinivasan, S. S., Lynch, N., Langer, R., White, F. M., & Cima, M. J. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122317 · Cited by 30 · see citing works

Cardiac optogenetics: a novel approach to cardiovascular disease therapy

Jiang, C., Li, H. T., Zhou, Y. M., Wang, X., Wang, L., & Liu, Z. Q. (2017) · EP Europace · doi:10.1093/europace/eux345 · Cited by 31 · see citing works

A Hybridization of Cuckoo Search and Differential Evolution for the Logistics Distribution Center Location Problem

Chi, R., Su, Y., Qu, Z., & Chi, X. (2019) · Mathematical Problems in Engineering · doi:10.1155/2019/7051248 · Cited by 29 · see citing works

Overview on Research and Clinical Applications of Optogenetics

Towne, C. L., & Thompson, K. R. (2016) · Current Protocols in Pharmacology · doi:10.1002/cpph.13 · Cited by 29 · see citing works

On-demand optogenetic activation of human stem-cell-derived neurons

Klapper, S. D., Sauter, E. J., Swiersy, A., Hyman, M. A. E., Bamann, C., Bamberg, E., & Busskamp, V. (2017) · Scientific Reports · doi:10.1038/s41598-017-14827-6 · Cited by 28 · see citing works

Towards the clinical translation of optogenetic skeletal muscle stimulation

Gundelach, L. A., Hüser, M. A., Beutner, D., Ruther, P., & Bruegmann, T. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02387-0 · Cited by 27 · see citing works

Restoring motor function using optogenetics and neural engraftment

Bryson, J. B., Machado, C. B., Lieberam, I., & Greensmith, L. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.02.016 · Cited by 25 · see citing works

Functional imaging for regenerative medicine

Leahy, M. J., Thompson, K., Zafar, H., Alexandrov, S., Foley, M. J., O’Flatharta, C., & Dockery, P. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0315-2 · Cited by 27 · see citing works

Human Induced Pluripotent Stem Cell–Derived Motor Neuron Transplant for Neuromuscular Atrophy in a Mouse Model of Sciatic Nerve Injury

Pepper, J., Wang, T. V., Hennes, V., Sun, S. Y., & Ichida, J. K. (2016) · JAMA Facial Plastic Surgery · doi:10.1001/jamafacial.2016.1544 · Cited by 26 · see citing works

Subtype diversification and synaptic specificity of stem cell-derived spinal interneurons

Hoang, P. T., Chalif, J. I., Bikoff, J. B., Jessell, T. M., Mentis, G. Z., & Wichterle, H. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.016 · Cited by 25 · see citing works

Directed midbrain and spinal cord neurogenesis from pluripotent stem cells to model development and disease in a dish

Allodi, I., & Hedlund, E. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00109 · Cited by 24 · see citing works

Stem Cell Neurodevelopmental Solutions for Restorative Treatments of the Human Trunk and Spine

Olmsted, Z. T., & Paluh, J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.667590 · Cited by 21 · see citing works

Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates

Williams, J. J., Watson, A. M., Vazquez, A. L., & Schwartz, A. B. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00759 · Cited by 23 · see citing works

Optogenetic neuromuscular actuation of a miniature electronic biohybrid robot

Min, H., Wang, Y., Wang, J., Li, X., Kim, W., Aydin, O., Kang, S., You, J., Lim, J., Wolhaupter, K., et al. (2025) · Science Robotics · doi:10.1126/scirobotics.adu5830 · Cited by 21 · see citing works

A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies

Liu, F., Wu, Y., Almarri, N., Habibollahi, M., Lancashire, H. T., Bryson, J. B., Greensmith, L., Jiang, D., & Demosthenous, A. (2022) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2022.3202026 · Cited by 21 · see citing works

Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections

Paredes‐Redondo, A., Harley, P., Maniati, E., Ryan, D., Louzada, S., Meng, J., Kowala, A., Fu, B., Yang, F., Liu, P., et al. (2021) · Science Advances · doi:10.1126/sciadv.abi8787 · Cited by 20 · see citing works

Optogenetic activation of muscle contraction in vivo

Ganji, E., Chan, C. S., Ward, C. W., & Killian, M. L. (2020) · Connective Tissue Research · doi:10.1080/03008207.2020.1798943 · Cited by 19 · see citing works

Peripheral optogenetic stimulation induces whisker movement and sensory perception in head-fixed mice

Park, S., Bandi, A., Lee, C. R., & Margolis, D. J. (2016) · eLife · doi:10.7554/elife.14140 · Cited by 19 · see citing works

Transplantation of embryonic spinal cord neurons to the injured distal nerve promotes axonal regeneration after delayed nerve repair

Zhang, W., Fang, X., Zhang, C., Li, W., Wong, W. M., Xu, Y., Wu, W., & Lin, J. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13495 · Cited by 19 · see citing works

Optical Stimulation for Restoration of Motor Function After Spinal Cord Injury

Mallory, G. W., Grahn, P. J., Hachmann, J. T., Luján, J. L., & Lee, K. H. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.12.004 · Cited by 18 · see citing works

Transgenic GDNF Positively Influences Proliferation, Differentiation, Maturation and Survival of Motor Neurons Produced from Mouse Embryonic Stem Cells

Cortés, D., Robledo-Arratia, Y., Hernandez-Martinez, R., Escobedo-Ávila, I., Bargas, J., & Velasco, I. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00217 · Cited by 18 · see citing works

Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells

Pomeroy, J. E., Nguyen, H. X., Hoffman, B. D., & Bursac, N. (2017) · Theranostics · doi:10.7150/thno.20593 · Cited by 18 · see citing works

Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease

Inglés‐Prieto, Á., Furthmann, N., Crossman, S. H., Tichy, A., Hoyer, N., Petersen, M., Zheden, V., Biebl, J., Reichhart, E., Gyoergy, A., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009479 · Cited by 18 · see citing works

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons

Bu, A., Afghah, F., Castro, N., Bawa, M., Kohli, S., Shah, K., Rios, B., Butty, V. L., & Raman, R. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202403712 · Cited by 17 · see citing works

Optogenetics Applications for Treating Spinal Cord Injury

Ahmad, A., Ashraf, S., & Komai, S. (2015) · Asian Spine Journal · doi:10.4184/asj.2015.9.2.299 · Cited by 17 · see citing works

Microflow-mediated optical assembly of nanoparticles with femtogram protein via shrinkage of light-induced bubbles

Ueda, M., Nishimura, Y., Tamura, M., Ito, S., Tokonami, S., & Iida, T. (2019) · APL Photonics · doi:10.1063/1.5079306 · Cited by 17 · see citing works

Optogenetics: Novel Tools for Controlling Mammalian Cell Functions with Light

Kushibiki, T., Okawa, S., Hirasawa, T., & Ishihara, M. (2014) · International Journal of Photoenergy · doi:10.1155/2014/895039 · Cited by 17 · see citing works

Synthetic mechanobiology: engineering cellular force generation and signaling

Hughes, J. H., & Kumar, S. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.03.004 · Cited by 17 · see citing works

In vitro models of spinal motor circuit’s development in mammals: achievements and challenges

Nedelec, S., & Martínez-Arias, A. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.12.002 · Cited by 14 · see citing works

Restoring the sense of touch

Anikeeva, P., & Koppes, R. A. (2015) · Science · doi:10.1126/science.aad0910 · Cited by 16 · see citing works

Modulating electrophysiology of motor neural networks via optogenetic stimulation during neurogenesis and synaptogenesis

Pagan‐Diaz, G. J., Drnevich, J. M., Ramos-Cruz, K. P., Sam, R., Sengupta, P., & Bashir, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-68988-y · Cited by 16 · see citing works

Human pluripotent stem cell tools for cardiac optogenetics

Zhuge, Y., Patlolla, B., Ramakrishnan, C., Beygui, R. E., Zarins, C. K., Deisseroth, K. A., Ellen Kuhl, A., & Abilez, O. J. (2014) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2014.6945038 · Cited by 15 · see citing works

Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini

Ramos, S. I., Makeyev, E. V., Salierno, M. J., Kodama, T., Kawakami, Y., & Sahara, S. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.01.036 · Cited by 15 · see citing works

Tumor prevention facilitates delayed transplant of stem cell‐derived motoneurons

Magown, P., Brownstone, R. M., & Rafuse, V. F. (2016) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.327 · Cited by 14 · see citing works

Optogenetics for neural transplant manipulation and functional analysis

Habibey, R., Sharma, K., Swiersy, A., & Busskamp, V. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.01.141 · Cited by 14 · see citing works

Boundary Cap Neural Crest Stem Cells Promote Survival of Mutant SOD1 Motor Neurons

Aggarwal, T., Hoeber, J., Ivert, P., Vasylovska, S., & Kozlova, E. N. (2017) · Neurotherapeutics · doi:10.1007/s13311-016-0505-8 · Cited by 14 · see citing works

hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation

Heuer, A., Kirkeby, A., Pfisterer, U., Jönsson, M. E., & Parmar, M. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.027 · Cited by 14 · see citing works

A brain center that controls consummatory responses

Canovas, J. A., Wang, L., Mohamed, A. A. M., Abbott, L. F., & Zuker, C. S. (2025) · Cell · doi:10.1016/j.cell.2025.08.021 · Cited by 13 · see citing works

Optogenetics in cancer drug discovery

Kiełbus, M., Czapiński, J., Odrzywolski, A., Stasiak, G., Szymanska, K., Kałafut, J., Kos, M., Giannopoulos, K., Stepulak, A., & Rivero‐Müller, A. (2018) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2018.1437138 · Cited by 13 · see citing works

Connectivity and circuitry in a dish versus in a brain

Chinchalongporn, V., Koppensteiner, P., Prè, D., Thangnipon, W., Bilo, L., & Arancio, O. (2015) · Alzheimer s Research & Therapy · doi:10.1186/s13195-015-0129-y · Cited by 13 · see citing works

Establishment of a Human Induced Pluripotent Stem Cell-Derived Neuromuscular Co-Culture Under Optogenetic ControlPreprint

Swartz, E. W., Shintani, G., Wan, J., Maffei, J. S., Wang, S. H., Miller, B. L., Havton, L. A., & Coppola, G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.10.036400 · Cited by 13 · see citing works

Endomicroscopy and electromyography of neuromuscular junctions in situ

Brown, R., Dissanayake, K. N., Skehel, P., & Ribchester, R. R. (2014) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.124 · Cited by 12 · see citing works

Advances in Optogenetics Applications for Central Nervous System Injuries

Geng, Y., Li, Z., Zhu, J., Du, C., Yuan, F., Cai, X., Ali, A., Yang, J., Tang, C., Cong, Z., et al. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2022.0290 · Cited by 12 · see citing works

Clinical applicability of optogenetic gene regulation

Wichert, N., Witt, M., Blume, C. A., & Scheper, T. H. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.27895 · Cited by 12 · see citing works

An Integrated Bidirectional Multi-Channel Opto-Electro Arbitrary Waveform Stimulator for Treating Motor Neurone Disease

Jiang, D., Wu, Y., Almarri, N., Habibollahi, M., Liu, F., Bryson, J. B., Greensmith, L., & Demosthenous, A. (2021) · 2021 IEEE International Symposium on Circuits and Systems (ISCAS) · doi:10.1109/iscas51556.2021.9401220 · Cited by 11 · see citing works

Spot light on skeletal muscles: optogenetic stimulation to understand and restore skeletal muscle function

Bremen, T. V., Send, T., Sasse, P., & Bruegmann, T. (2017) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-017-9481-9 · Cited by 11 · see citing works

Restoring motor function using optogenetics and neural engraftment

Bryson, J. B., Machado, C. B., Lieberam, I., & Greensmith, L. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.02.016 · Cited by 25 · see citing works

Using Optogenetics and Stem Cell-derived Neural Engraftment Techniques to Restore Lost Motor Function

Bryson, J. B., & Greensmith, L. (2017) · Cambridge University Press eBooks · doi:10.1017/9781107281875.023

MOTOR FUNCTION RESTORATION: THERAPEUTIC APPROACHES TO DENERVATION PATHOLOGIES

Magown, P. (2016) · DalSpace (Dalhousie University)

Let there be light and muscle contraction: optogenetic restoration of muscle function.

Gologorsky, Y., & Chi, J. (2014) · PubMed · doi:10.1227/01.neu.0000452317.84236.3e

Using stem cells and light to restore function to paralysed muscles

Bryson, J. B., & Greensmith, L. (2017) · Neuromuscular Disorders · doi:10.1016/s0960-8966(17)30219-5