Subtype diversification and synaptic specificity of stem cell-derived spinal interneurons
Open accessAbstract
Neuronal diversification is a fundamental step in the construction of functional neural circuits, but how neurons generated from single progenitor domains acquire diverse subtype identities remains poorly understood. Here we developed an embryonic stem cell (ESC)-based system to model subtype diversification of V1 interneurons, a class of spinal neurons comprising four clades collectively containing dozens of molecularly distinct neuronal subtypes. We demonstrate that V1 subtype diversity can be modified by extrinsic signals. Inhibition of Notch and activation of retinoid signaling results in a switch to MafA clade identity and enriches differentiation of Renshaw cells, a specialized MafA subtype that mediates recurrent inhibition of spinal motor neurons. We show that Renshaw cells are intrinsically programmed to migrate to species-specific laminae upon transplantation and to form subtype-specific synapses with motor neurons. Our results demonstrate that stem cell-derived neuronal subtypes can be used to investigate mechanisms underlying neuronal subtype specification and circuit assembly.
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Retinoic acid promotes Renshaw cell identity in V1 neurons.
“Retinoic acid (RA) promotes Renshaw cell identity in V1 neurons (Hoang et al., 2018), and the timepoint of their generation correlates with expression of the RA-synthesising enzyme Aldh1a2 in the adjacent somites (Niederreither et al., 1997).”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Hoang et al., 2018
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Zannino, D., Downes, G., & Sagerström, C. G. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.02.025 · Cited by 24 · see citing works
Wetts, R., & Vaughn, J. E. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1200 · Cited by 18 · see citing works
A Simple Procedure for the Efficient Derivation of Mouse ES Cells
Wong, E. S. M., Ban, K. H.-K., Mutalif, R., et al. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)76015-8 · Cited by 10 · see citing works
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Delile, J., Rayon, T., Melchionda, M., Edwards, A., Briscoe, J., & Sagner, A. (2019) · Development · doi:10.1242/dev.173807 · Cited by 356 · see citing works
Thams, S., Lowry, E. R., Larraufie, M.-H., Spiller, K. J., Li, H., Williams, D. J., Hoang, P., Jiang, E., Williams, L. A., Sandoe, J., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2018.10.010 · Cited by 51 · see citing works
Self-citation
- Authors
- Hoang, P. T., Chalif, J. I., Bikoff, J. B., Jessell, T. M., Mentis, G. Z., & Wichterle, H.
- Affiliations
- Columbia University Irving Medical Center (US)
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Wichterle, Hynek
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 100
- Issue
- 1
- Pages
- 135-149.e7
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC6590086
- OpenAlex
- W2896423589
- Cited by
- 25
- References
- 99
- Citations by year
- 2024: 5 · 2022: 7 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 2
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH NRSA (F30NS092262, F30NS098551)
- NIH (T32NS064928, T32GM007367, NS078097, NS092043, NS033245, NS078375)
- Jerry and Emily Spiegel
- Project ALS
- Target ALS
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- neuronal subtype specification, spinal interneurons, Renshaw cells, Notch signaling, retinoid signaling, embryonic stem cell differentiation, synaptic specificity
- MeSH terms
- Animals, Cell Differentiation, Interneurons, Motor Neurons, Spinal Cord, Synapses, Mice, Embryonic Stem Cells, Neurogenesis, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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