The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions
Abstract
How Tight?: In metazoans, sheets of epithelial cells separate different tissue spaces and control their composition. Tight junctions are cell-cell adhesion structures in these cell sheets that form a seal between cells but also provide some selective permeability to ions and small molecules. Claudins are the main constituents of tight junctions, and mutations in claudins cause inherited human disorders involving the disruption of ionic balance. Suzuki et al. (p. 304 ) report the structure of mouse claudin-15 at 2.4 angstrom resolution, which shows an extracellular β-sheet domain anchored to a transmembrane four-helix bundle. The electrostatic distribution on the claudin surface reveals a negatively charged groove in the extracellular domain that may provide a pathway for positive ions.
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[20] Processing of X-ray diffraction data collected in oscillation mode
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PHENIX : a comprehensive Python-based system for macromolecular structure solution
Adams, P. D., Afonine, P. V., Bunkóczi, G., Chen, V. B., Davis, I. W., Echols, N., Headd, J. J., Hung, L.-W., Kapral, G. J., Grosse-Kunstleve, R. W., et al. (2010) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444909052925 · Cited by 23,716
Kabsch, W. (2010) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444909047337 · Cited by 16,463
Terwilliger, T. C., Grosse-Kunstleve, R. W., Afonine, P. V., Moriarty, N. W., Zwart, P. H., Hung, L.-W., Read, R. J., & Adams, P. D. (2008) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s090744490705024x · Cited by 1,462
Claudins and the Modulation of Tight Junction Permeability
Günzel, D., & Yu, A. S. L. (2013) · Physiological Reviews · doi:10.1152/physrev.00019.2012 · Cited by 1,456
Structure, function, and regulation of cellular tight junctions
Schneeberger, E. E., & Lynch, R. D. (1992) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1992.262.6.l647 · Cited by 518
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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686
Claudin-5: gatekeeper of neurological function
Greene, C., Hanley, N., & Campbell, M. (2019) · Fluids and Barriers of the CNS · doi:10.1186/s12987-019-0123-z · Cited by 583
Luissint, A.-C., Parkos, C. A., & Nusrat, A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.07.008 · Cited by 555
Architecture of tight junctions and principles of molecular composition
Van Itallie, C. M., & Anderson, J. M. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.08.011 · Cited by 544
The Claudins: From Tight Junctions to Biological Systems
Tsukita, S., Tanaka, H., & Tamura, A. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.09.008 · Cited by 470
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Metadata
- Authors
- Suzuki, H., Nishizawa, T., Tani, K., Yamazaki, Y., Tamura, A., Ishitani, R., Dohmae, N., Tsukita, S., Nureki, O., & Fujiyoshi, Y.
- Venue
- Science
- Published
- 2014-04-18
- Volume
- 344
- Issue
- 6181
- Pages
- 304-307
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994837626
- Cited by
- 366
- References
- 6
- FWCI
- 18.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Suzuki, H., Nishizawa, T., Tani, K., Yamazaki, Y., Tamura, A., Ishitani, R., Dohmae, N., Tsukita, S., Nureki, O., & Fujiyoshi, Y. (2014). Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions. Science. https://doi.org/10.1126/science.1248571
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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