The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Complement Is Activated by IgG Hexamers Assembled at the Cell Surface
Open accessAbstract
Hexing Complement: Complement activation is an immediate and potent immune defense mechanism, but how immunoglobulin G (IgG) antibodies activate complement at the molecular level is poorly understood. Using high-resolution crystallography, Diebolder et al. (p. 1260 ) show that human IgGs form hexameric structures by interacting with neighboring IgG molecules, and the complex then activates complement. Thus, IgG molecules and the complement system can coexist in the blood because complement activation will only be triggered after IgG senses a surface antigen and starts to aggregate.
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Cites
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654
Complement and its role in innate and adaptive immune responses
Dunkelberger, J. R., & Song, W.-C. (2010) · Cell Research · doi:10.1038/cr.2009.139 · Cited by 1,932
Teeling, J. L. (2004) · Blood · doi:10.1182/blood-2004-01-0039 · Cited by 630
Cited by
IgG Subclasses and Allotypes: From Structure to Effector Functions
Vidarsson, G., Dekkers, G., & Rispens, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00520 · Cited by 2,667
Complement System Part I – Molecular Mechanisms of Activation and Regulation
Merle, N. S., Church, S. E., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00262 · Cited by 1,620
Staphylococcus aureus host interactions and adaptation
Howden, B. P., Giulieri, S. G., Wong Fok Lung, T., Baines, S. L., Sharkey, L. K., Lee, J. Y. H., Hachani, A., Monk, I. R., & Stinear, T. P. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00852-y · Cited by 689
High-Resolution Native Mass Spectrometry
Tamara, S., den Boer, M. A., & Heck, A. J. R. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00212 · Cited by 511
Self-citationContext-dependent roles of complement in cancer
Roumenina, L. T., Daugan, M. V., Petitprez, F., Sautès-Fridman, C., & Fridman, W. H. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0210-0 · Cited by 389
Metadata
- Authors
- Diebolder, C. A., Beurskens, F. J., de Jong, R. N., Koning, R. I., Strumane, K., Lindorfer, M. A., Voorhorst, M., Ugurlar, D., Rosati, S., Heck, A. J. R., van de Winkel, J. G. J., Wilson, I. A., Koster, A. J., Taylor, R. P., Ollmann Saphire, E., Burton, D. R., Schuurman, J., Gros, P., & Parren, P. W. H. I.
- Venue
- Science
- Published
- 2014-03-14
- Volume
- 343
- Issue
- 6176
- Pages
- 1260-1263
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985960971
- Cited by
- 796
- References
- 3
- FWCI
- 22.17
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Diebolder, C. A., Beurskens, F. J., de Jong, R. N., Koning, R. I., Strumane, K., Lindorfer, M. A., Voorhorst, M., Ugurlar, D., Rosati, S., Heck, A. J. R., van de Winkel, J. G. J., Wilson, I. A., Koster, A. J., Taylor, R. P., Ollmann Saphire, E., Burton, D. R., Schuurman, J., Gros, P., & Parren, P. W. H. I. (2014). Complement Is Activated by IgG Hexamers Assembled at the Cell Surface. Science. https://doi.org/10.1126/science.1248943
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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