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Conversion of Channelrhodopsin into a Light-Gated Chloride Channel
Abstract
Optogenetic Insights: Mapping functional neural circuits for many behaviors has been almost impossible, so Vogelstein et al. (p. 386 , published online 27 March; see the Perspective by O'Leary and Marder ) developed a broadly applicable optogenetic method for neuron-behavior mapping and used it to phenotype larval Drosophila and thus developed a reference atlas. As optogenetic experiments become routine in certain fields of neuroscience research, creating even more specialized tools is imperative (see the Perspective by Hayashi ). By engineering channelrhodopsin, Wietek et al. (p. 409 , published online 27 March) and Berndt et al. (p. 420 ) created two different light-gated anion channels to block action potential generation during synaptic stimulation or depolarizing current injections. These new tools not only improve understanding of channelrhodopsins but also provide a way to silence cells.
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Citations
Cited by
Integration of optogenetics with complementary methodologies in systems neuroscience
Kim, C. K., Adhikari, A., & Deisseroth, K. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.15 · Cited by 690
Microbial Rhodopsins: Diversity, Mechanisms, and Optogenetic Applications
Govorunova, E. G., Sineshchekov, O. A., Li, H., & Spudich, J. L. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-101910-144233 · Cited by 363
Silencing Neurons: Tools, Applications, and Experimental Constraints
Wiegert, J. S., Mahn, M., Prigge, M., Printz, Y., & Yizhar, O. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.050 · Cited by 312
Self-citationOptogenetic inhibition of behavior with anion channelrhodopsins
Mohammad, F., Stewart, J. C., Ott, S., Chlebikova, K., Chua, J. Y., Koh, T.-W., Ho, J., & Claridge-Chang, A. (2017) · Nature Methods · doi:10.1038/nmeth.4148 · Cited by 276
Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics
Bedbrook, C. N., Yang, K. K., Robinson, J. E., Mackey, E. D., Gradinaru, V., & Arnold, F. H. (2019) · Nature Methods · doi:10.1038/s41592-019-0583-8 · Cited by 205
Metadata
- Authors
- Wietek, J., Wiegert, J. S., Adeishvili, N., Schneider, F., Watanabe, H., Tsunoda, S. P., Vogt, A., Elstner, M., Oertner, T. G., & Hegemann, P.
- Venue
- Science
- Published
- 2014-04-25
- Volume
- 344
- Issue
- 6182
- Pages
- 409-412
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2074089338
- Cited by
- 348
- References
- 0
- FWCI
- 23.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wietek, J., Wiegert, J. S., Adeishvili, N., Schneider, F., Watanabe, H., Tsunoda, S. P., Vogt, A., Elstner, M., Oertner, T. G., & Hegemann, P. (2014). Conversion of Channelrhodopsin into a Light-Gated Chloride Channel. Science. https://doi.org/10.1126/science.1249375
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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