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Structure of the Yeast Mitochondrial Large Ribosomal Subunit

Open access
Amunts, Alexey, Brown, Alan, Bai, Xiao-chen, Llácer, Jose L., Hussain, Tanweer, Emsley, Paul, Long, Fei, Murshudov, Garib, Scheres, Sjors H. W., Ramakrishnan, V.·2014·Science

Abstract

Mitoribosomes: Mitochondria—found in all eukaryotic cells—have transferred most of their genes to the nuclear genome. The nuclear-localized mitochondrial genes are expressed and translated in the cytoplasm and the resulting mitochondrial proteins are imported into the mitochondria. Nevertheless, a few genes remain within mitochondria in the mitochondrial genome, and these genes are translated by mitochondrial ribosomes (mitoribosomes). Amunts et al. (p. 1485 ; see the Perspective by Kühlbrandt ) determined the structure of mitoribosomes from yeast using single-particle cryo–electron microscopy. The mitoribosome is highly diverged from the bacterial and eukaryotic ribosomes with, for example, a distinctive exit tunnel for the newly synthesized peptide, and a membrane facing protuberance that might help to anchor the mitoribosome to the mitochondrial membrane.

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Metadata

Authors
Amunts, A., Brown, A., Bai, X.-C., Llácer, J. L., Hussain, T., Emsley, P., Long, F., Murshudov, G., Scheres, S. H. W., & Ramakrishnan, V.
Venue
Science
Published
2014-03-28
Volume
343
Issue
6178
Pages
1485-1489
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2150790075
Cited by
579
References
4
FWCI
29.20
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Structure of the Yeast Mitochondrial Large Ribosomal Subunit. https://app.cochat.ai/papers/10.1126/science.1249410
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Amunts, A., Brown, A., Bai, X.-C., Llácer, J. L., Hussain, T., Emsley, P., Long, F., Murshudov, G., Scheres, S. H. W., & Ramakrishnan, V. (2014). Structure of the Yeast Mitochondrial Large Ribosomal Subunit. Science. https://doi.org/10.1126/science.1249410

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