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Structure of the Yeast Mitochondrial Large Ribosomal Subunit
Open accessAbstract
Mitoribosomes: Mitochondria—found in all eukaryotic cells—have transferred most of their genes to the nuclear genome. The nuclear-localized mitochondrial genes are expressed and translated in the cytoplasm and the resulting mitochondrial proteins are imported into the mitochondria. Nevertheless, a few genes remain within mitochondria in the mitochondrial genome, and these genes are translated by mitochondrial ribosomes (mitoribosomes). Amunts et al. (p. 1485 ; see the Perspective by Kühlbrandt ) determined the structure of mitoribosomes from yeast using single-particle cryo–electron microscopy. The mitoribosome is highly diverged from the bacterial and eukaryotic ribosomes with, for example, a distinctive exit tunnel for the newly synthesized peptide, and a membrane facing protuberance that might help to anchor the mitoribosome to the mitochondrial membrane.
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Metadata
- Authors
- Amunts, A., Brown, A., Bai, X.-C., Llácer, J. L., Hussain, T., Emsley, P., Long, F., Murshudov, G., Scheres, S. H. W., & Ramakrishnan, V.
- Venue
- Science
- Published
- 2014-03-28
- Volume
- 343
- Issue
- 6178
- Pages
- 1485-1489
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2150790075
- Cited by
- 579
- References
- 4
- FWCI
- 29.20
- Type
- journal article
- Language
- en
- Open access
- green
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