The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC
Abstract
One Swell Ion Channel: When mammalian cells are faced with osmotic challenges, they need to swell or shrink. The molecular characterization of the volume-regulated anion channel (VRAC) remains unknown, although many candidate proteins have been proposed. Voss et al. (p. 634 , published online 10 April; see the Perspective by Mindell ) used a genome-wide screen to identify a group of leucine-rich repeat–containing (LRRC) proteins necessary for forming VRAC. Suppression of LRRC8A nearly eliminated the presence of VRAC in mammalian cells. A heterooligomer of LRRC proteins appears to form VRAC. Identification of VRAC components is an essential step forward in the understanding of swelling-activated ion channels and provides opportunities for understanding both the mechanism of the channel and its role in physiology.
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Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339
RNA-Guided Human Genome Engineering via Cas9
Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Cited by
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793
Mechanically Activated Ion Channels
Ranade, S. S., Syeda, R., & Patapoutian, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.032 · Cited by 652
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo
Wu, Z., He, K., Chen, Y., Li, H., Pan, S., Li, B., Liu, T., Xi, F., Deng, F., Wang, H., et al. (2022) · Neuron · doi:10.1016/j.neuron.2021.11.027 · Cited by 204
Metadata
- Authors
- Voss, F. K., Ullrich, F., Münch, J., Lazarow, K., Lutter, D., Mah, N., Andrade-Navarro, M. A., von Kries, J. P., Stauber, T., & Jentsch, T. J.
- Venue
- Science
- Published
- 2014-05-09
- Volume
- 344
- Issue
- 6184
- Pages
- 634-638
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2046464107
- Cited by
- 619
- References
- 3
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Voss, F. K., Ullrich, F., Münch, J., Lazarow, K., Lutter, D., Mah, N., Andrade-Navarro, M. A., von Kries, J. P., Stauber, T., & Jentsch, T. J. (2014). Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC. Science. https://doi.org/10.1126/science.1252826
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