The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
Open accessAbstract
Human adult stem cell expansion: Transfused blood saves lives. Despite the widespread use of this critical resource, it is difficult to increase blood cell numbers outside of the body. By screening thousands of small compounds, Fares et al. identify a molecule that expands human stem cell numbers in cord blood. The researchers generate many variations of that molecule and show that one such compound provides even greater human blood cell expansion. If researchers can provide increased numbers of stem cells and progenitor cells, cord blood should find even greater use in the clinic. Science , this issue p. 1509
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Cites
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HLA Match Likelihoods for Hematopoietic Stem-Cell Grafts in the U.S. Registry
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Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells
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Long-Term Propagation of Distinct Hematopoietic Differentiation Programs In Vivo
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Self-citationIdentification of a Hierarchy of Multipotent Hematopoietic Progenitors in Human Cord Blood
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Cited by
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
Dever, D. P., Bak, R. O., Reinisch, A., Camarena, J., Washington, G., Nicolas, C. E., Pavel-Dinu, M., Saxena, N., Wilkens, A. B., Mantri, S., et al. (2016) · Nature · doi:10.1038/nature20134 · Cited by 864
Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration
Zhang, Y., Desai, A., Yang, S. Y., Bae, K. B., Antczak, M. I., Fink, S. P., Tiwari, S., Willis, J. E., Williams, N. S., Dawson, D. M., et al. (2015) · Science · doi:10.1126/science.aaa2340 · Cited by 297
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology
Chou, D. B., Frismantas, V., Milton, Y., David, R., Pop-Damkov, P., Ferguson, D., MacDonald, A., Vargel Bölükbaşı, Ö., Joyce, C. E., Moreira Teixeira, L. S., et al. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0495-z · Cited by 294
Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion
Li, Z., Qian, P., Shao, W., Shi, H., He, X. C., Gogol, M., Yu, Z., Wang, Y., Qi, M., Zhu, Y., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0072-0 · Cited by 257
Haematopoietic stem cell self-renewal in vivo and ex vivo
Wilkinson, A. C., Igarashi, K. J., & Nakauchi, H. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0241-0 · Cited by 226
Metadata
- Authors
- Fares, I., Chagraoui, J., Gareau, Y., Gingras, S., Ruel, R., Mayotte, N., Csaszar, E., Knapp, D. J. H. F., Miller, P., Ngom, M., Imren, S., Roy, D.-C., Watts, K. L., Kiem, H.-P., Herrington, R., Iscove, N. N., Humphries, R. K., Eaves, C. J., Cohen, S., Marinier, A., Zandstra, P. W., & Sauvageau, G.
- Venue
- Science
- Published
- 2014-09-19
- Volume
- 345
- Issue
- 6203
- Pages
- 1509-1512
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081409454
- Cited by
- 565
- References
- 19
- FWCI
- 26.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Fares, I., Chagraoui, J., Gareau, Y., Gingras, S., Ruel, R., Mayotte, N., Csaszar, E., Knapp, D. J. H. F., Miller, P., Ngom, M., Imren, S., Roy, D.-C., Watts, K. L., Kiem, H.-P., Herrington, R., Iscove, N. N., Humphries, R. K., Eaves, C. J., Cohen, S., . . . Sauvageau, G. (2014). Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science. https://doi.org/10.1126/science.1256337
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
