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Cited by 474

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Antibody landscapes after influenza virus infection or vaccination

Open access
Fonville, J. M., Wilks, S. H., James, S. L., Fox, A., Ventresca, M., Aban, M., Xue, L., Jones, T. C., Le N. M. H., Pham Q. T., Tran N. D., Wong, Y., Mosterin, A., Katzelnick, L. C., Labonte, D., Le T. T., van der Net, G., Skepner, E., Russell, C. A., Kaplan, T. D., Rimmelzwaan, G. F., Masurel, N., de Jong, J. C., Palache, A., Beyer, W. E. P., Le Q. M., Nguyen T. H., Wertheim, H. F. L., Hurt, A. C., Osterhaus, A. D. M. E., Barr, I. G., Fouchier, R. A. M., Horby, P. W., Smith, D. J.·2014·Science

Abstract

We introduce the antibody landscape, a method for the quantitative analysis of antibody-mediated immunity to antigenically variable pathogens, achieved by accounting for antigenic variation among pathogen strains. We generated antibody landscapes to study immune profiles covering 43 years of influenza A/H3N2 virus evolution for 69 individuals monitored for infection over 6 years and for 225 individuals pre- and postvaccination. Upon infection and vaccination, titers increased broadly, including previously encountered viruses far beyond the extent of cross-reactivity observed after a primary infection. We explored implications for vaccination and found that the use of an antigenically advanced virus had the dual benefit of inducing antibodies against both advanced and previous antigenic clusters. These results indicate that preemptive vaccine updates may improve influenza vaccine efficacy in previously exposed individuals.

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Metadata

Authors
Fonville, J. M., Wilks, S. H., James, S. L., Fox, A., Ventresca, M., Aban, M., Xue, L., Jones, T. C., H., L. N. M., T., P. Q., D., T. N., Wong, Y., Mosterin, A., Katzelnick, L. C., Labonte, D., T., L. T., van der Net, G., Skepner, E., Russell, C. A., Kaplan, T. D., Rimmelzwaan, G. F., Masurel, N., de Jong, J. C., Palache, A., Beyer, W. E. P., M., L. Q., H., N. T., Wertheim, H. F. L., Hurt, A. C., Osterhaus, A. D. M. E., Barr, I. G., Fouchier, R. A. M., Horby, P. W., & Smith, D. J.
Venue
Science
Published
2014-11-21
Volume
346
Issue
6212
Pages
996-1000
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2036236122
Cited by
474
References
1
FWCI
20.90
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Antibody landscapes after influenza virus infection or vaccination. https://app.cochat.ai/papers/10.1126/science.1256427
The paper
Fonville, J. M., Wilks, S. H., James, S. L., Fox, A., Ventresca, M., Aban, M., Xue, L., Jones, T. C., H., L. N. M., T., P. Q., D., T. N., Wong, Y., Mosterin, A., Katzelnick, L. C., Labonte, D., T., L. T., van der Net, G., Skepner, E., Russell, C. A., . . . Smith, D. J. (2014). Antibody landscapes after influenza virus infection or vaccination. Science. https://doi.org/10.1126/science.1256427

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.