Immunological imprinting of the antibody response in COVID-19 patients
Open accessPublished version of a preprint
Abstract
In addition to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), humans are also susceptible to six other coronaviruses, for which consecutive exposures to antigenically related and divergent seasonal coronaviruses are frequent. Despite the prevalence of COVID-19 pandemic and ongoing research, the nature of the antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Here we longitudinally profile the early humoral immune response against SARS-CoV-2 in hospitalized coronavirus disease 2019 (COVID-19) patients and quantify levels of pre-existing immunity to OC43, HKU1 and 229E seasonal coronaviruses, and find a strong back-boosting effect to conserved but not variable regions of OC43 and HKU1 betacoronaviruses spike protein. However, such antibody memory boost to human coronaviruses negatively correlates with the induction of IgG and IgM against SARS-CoV-2 spike and nucleocapsid protein. Our findings thus provide evidence of immunological imprinting by previous seasonal coronavirus infections that can potentially modulate the antibody profile to SARS-CoV-2 infection.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SARS-CoV-2 infection induces an original antigenic sin-type immune response against human coronaviruses to which most people have pre-existing immunity.
“It has been reported that SARS-CoV-2 infection induces an original antigenic sin-type immune response against human coronaviruses (hCoVs) to which the majority of the human population has pre-existing immunity”
From SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2 (2021) · cites this paper as Aydillo et al., 2021
A backboost to β-coronaviruses has been reported for natural SARS-CoV-2 infection.
“has already been shown for natural infection with SARS-CoV-2 where a “backboost” to β-coronaviruses was also found (Aydillo et al., 2021; Song et al., 2020).”
From SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2 (2021) · cites this paper as Aydillo et al., 2021
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A novel coronavirus from patients with pneumonia in China, 2019
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001017 · Cited by 28,244 · see citing works
Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein
Walls, A. C., Park, Y.-J., Tortorici, M. A., Wall, A., McGuire, A. T., & Veesler, D. (2020) · doi:10.1101/2020.02.19.956581 · Cited by 8,586 · see citing works
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211721 · Cited by 5,677 · see citing works
Grifoni, A., Weiskopf, D., Ramirez, S. I., Mateus, J., Dan, J. M., Moderbacher, C. R., Rawlings, S. A., Sutherland, A., Premkumar, L., Jadi, R. S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.015 · Cited by 3,595 · see citing works
Self-citationAn mRNA Vaccine against SARS-CoV-2 — Preliminary Report
Jackson, L. A., Anderson, E. J., Rouphael, N. G., Roberts, P. C., Makhene, M., Coler, R. N., McCullough, M. P., Chappell, J. D., Denison, M. R., Stevens, L. J., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2022483 · Cited by 3,237 · see citing works
Letko, M., Marzi, A., & Munster, V. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0688-y · Cited by 3,109 · see citing works
Coronavirus as a possible cause of severe acute respiratory syndrome
Peiris, M. J. S., Lai, S., Poon, L. L. M., Guan, Y., Yam, L., Lim, W., Nicholls, J. M., Yee, W., Yan, W., Cheung, M., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13077-2 · Cited by 2,916 · see citing works
Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
Wang, Q., Zhang, Y., Wu, L., Niu, S., Song, C., Zhang, Z., Lu, G., Qiao, C., Hu, Y., Yuen, K.-Y., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.045 · Cited by 2,892 · see citing works
An inflammatory cytokine signature predicts COVID-19 severity and survival
Del Valle, D. M., Kim-Schulze, S., Huang, H.-H., Beckmann, N. D., Nirenberg, S., Wang, B., Lavin, Y., Swartz, T. H., Madduri, D., Stock, A., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1051-9 · Cited by 2,605 · see citing works
Bi, Q., Wu, Y., Mei, S., Ye, C., Zou, X., Zhang, Z., Liu, X., Wei, L., Truelove, S., Zhang, T., et al. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30287-5 · Cited by 1,960 · see citing works
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
Ge, X.-Y., Li, J.-L., Yang, X.-L., Chmura, A. A., Zhu, G., Epstein, J. H., Mazet, J. K., Hu, B., Zhang, W., Peng, C., et al. (2013) · Nature · doi:10.1038/nature12711 · Cited by 1,778 · see citing works
A serological assay to detect SARS-CoV-2 seroconversion in humans
Amanat, F., Stadlbauer, D., Strohmeier, S., Nguyen, T. H. O., Chromikova, V., McMahon, M., Jiang, K., Arunkumar, G. A., Jurczyszak, D., Polanco, J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0913-5 · Cited by 1,769 · see citing works
Self-citationHuman neutralizing antibodies elicited by SARS-CoV-2 infection
Ju, B., Zhang, Q., Ge, J., Wang, R., Sun, J., Ge, X., Yu, J., Shan, S., Zhou, B., Song, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2380-z · Cited by 1,667 · see citing works
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
Yuan, M., Wu, N. C., Zhu, X., Lee, C.-C. D., So, R. T. Y., Lv, H., Mok, C. K. P., & Wilson, I. A. (2020) · Science · doi:10.1126/science.abb7269 · Cited by 1,405 · see citing works
Piccoli, L., Park, Y.-J., Tortorici, M. A., Czudnochowski, N., Walls, A. C., Beltramello, M., Silacci-Fregni, C., Pinto, D., Rosen, L. E., Bowen, J. E., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.037 · Cited by 1,395 · see citing works
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19
Braun, J., Loyal, L., Frentsch, M., Wendisch, D., Georg, P., Kurth, F., Hippenstiel, S., Dingeldey, M., Kruse, B., Fauchere, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2598-9 · Cited by 1,310 · see citing works
A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2
Shi, R., Shan, C., Duan, X., Chen, Z., Liu, P., Song, J., Song, T., Bi, X., Han, C., Wu, L., et al. (2020) · Nature · doi:10.1038/s41586-020-2381-y · Cited by 1,286 · see citing works
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
Walls, A. C., Park, Y., Tortorici, M. A., Wall, A., McGuire, A. T., & Veesler, D. (2020) · Cell · doi:10.1016/j.cell.2020.11.032 · Cited by 1,283 · see citing works
SARS-CoV-2 Vaccines: Status Report
Amanat, F., & Krammer, F. (2020) · Immunity · doi:10.1016/j.immuni.2020.03.007 · Cited by 1,120 · see citing works
Self-citationSelective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans
Mateus, J., Grifoni, A., Tarke, A., Sidney, J., Ramirez, S. I., Dan, J. M., Burger, Z. C., Rawlings, S. A., Smith, D. M., Phillips, E., et al. (2020) · Science · doi:10.1126/science.abd3871 · Cited by 1,120 · see citing works
Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic
Boni, M. F., Lemey, P., Jiang, X., Lam, T. T.-Y., Perry, B. W., Castoe, T. A., Rambaut, A., & Robertson, D. L. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0771-4 · Cited by 1,014 · see citing works
ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques
van Doremalen, N., Lambe, T., Spencer, A., Belij-Rammerstorfer, S., Purushotham, J. N., Port, J. R., Avanzato, V. A., Bushmaker, T., Flaxman, A., Ulaszewska, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2608-y · Cited by 914 · see citing works
Weiskopf, D., Schmitz, K. S., Raadsen, M. P., Grifoni, A., Okba, N. M. A., Endeman, H., van den Akker, J. P. C., Molenkamp, R., Koopmans, M. P. G., van Gorp, E. C. M., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abd2071 · Cited by 907 · see citing works
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Ng, K. W., Faulkner, N., Cornish, G. H., Rosa, A., Harvey, R., Hussain, S., Ulferts, R., Earl, C., Wrobel, A. G., Benton, D. J., et al. (2020) · Science · doi:10.1126/science.abe1107 · Cited by 886 · see citing works
Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques
Mercado, N. B., Zahn, R., Wegmann, F., Loos, C., Chandrashekar, A., Yu, J., Liu, J., Peter, L., McMahan, K., Tostanoski, L. H., et al. (2020) · Nature · doi:10.1038/s41586-020-2607-z · Cited by 789 · see citing works
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase
Wang, Q., Wu, J., Wang, H., Gao, Y., Liu, Q., Mu, A., Ji, W., Yan, L., Zhu, Y., Zhu, C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.034 · Cited by 779 · see citing works
Molecular Evolution of Human Coronavirus Genomes
Forni, D., Cagliani, R., Clerici, M., & Sironi, M. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.09.001 · Cited by 741 · see citing works
Emerging Pandemic Diseases: How We Got to COVID-19
Morens, D. M., & Fauci, A. S. (2020) · Cell · doi:10.1016/j.cell.2020.08.021 · Cited by 720 · see citing works
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
Shrock, E., Fujimura, E., Kula, T., Timms, R. T., Lee, I.-H., Leng, Y., Robinson, M. L., Sie, B. M., Li, M. Z., Chen, Y., et al. (2020) · Science · doi:10.1126/science.abd4250 · Cited by 678 · see citing works
Stadlbauer, D., Amanat, F., Chromikova, V., Jiang, K., Strohmeier, S., Arunkumar, G. A., Tan, J., Bhavsar, D., Capuano, C., Roubidoux, E. K., et al. (2020) · Current Protocols in Microbiology · doi:10.1002/cpmc.100 · Cited by 623 · see citing works
Self-citationImbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19
Meckiff, B. J., Ramírez-Suástegui, C., Fajardo, V., Chee, S., Kusnadi, A., Simon, H. A., Eschweiler, S., Grifoni, A., Pelosi, E., Weiskopf, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.001 · Cited by 564 · see citing works
Addetia, A., Crawford, K. H. D., Dingens, A., Zhu, H., Roychoudhury, P., Huang, M.-L., Jerome, K. R., Bloom, J. D., & Greninger, A. L. (2020) · Journal of Clinical Microbiology · doi:10.1128/jcm.02107-20 · Cited by 525 · see citing works
Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
Tortorici, M. A., Beltramello, M., Lempp, F. A., Pinto, D., Dang, H. V., Rosen, L. E., McCallum, M., Bowen, J., Minola, A., Jaconi, S., et al. (2020) · Science · doi:10.1126/science.abe3354 · Cited by 510 · see citing works
A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies
Hassan, A. O., Case, J. B., Winkler, E. S., Thackray, L. B., Kafai, N. M., Bailey, A. L., McCune, B. T., Fox, J. M., Chen, R. E., Alsoussi, W. B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.011 · Cited by 477 · see citing works
Antibody landscapes after influenza virus infection or vaccination
Fonville, J. M., Wilks, S. H., James, S. L., Fox, A., Ventresca, M., Aban, M., Xue, L., Jones, T. C., H., L. N. M., Thái, P. Q., et al. (2014) · Science · doi:10.1126/science.1256427 · Cited by 475 · see citing works
Erbelding, E. J., Post, D. J., Stemmy, E. J., Roberts, P. C., Augustine, A. D., Ferguson, S. E., Paules, C. I., Graham, B. S., & Fauci, A. S. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy103 · Cited by 440 · see citing works
Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections
Lv, H., Wu, N. C., Tsang, O. T.-Y., Yuan, M., Perera, R. A. P. M., Leung, W.-S., So, R. T. Y., Chan, J. M. C., Yip, G. K., Chik, T. S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107725 · Cited by 401 · see citing works
Hulswit, R. J. G., Lang, Y., Bakkers, M. J. G., Li, W., Li, Z., Schouten, A., Ophorst, B., van Kuppeveld, F. J. M., Boons, G., Bosch, B., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809667116 · Cited by 380 · see citing works
Original Antigenic Sin in Dengue
Halstead, S. B., Rojanasuphot, S., & SANGKAWIBHA, N. (1983) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1983.32.154 · Cited by 291 · see citing works
ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques
van Doremalen, N., Lambe, T., Spencer, A., Belij-Rammerstorfer, S., Purushotham, J. N., Port, J. R., Avanzato, V., Bushmaker, T., Flaxman, A., Ulaszewska, M., et al. (2020) · doi:10.1101/2020.05.13.093195 · Cited by 246 · see citing works
Nguyen-Contant, P., Embong, A. K., Kanagaiah, P., Chaves, F. A., Yang, H., Branche, A. R., Topham, D. J., & Sangster, M. Y. (2020) · mBio · doi:10.1128/mbio.01991-20 · Cited by 204 · see citing works
An In-Depth Analysis of Original Antigenic Sin in Dengue Virus Infection
Midgley, C. M., Bajwa-Joseph, M., Vasanawathana, S., Limpitikul, W., Wills, B. A., Flanagan, A., Waiyaiya, E., Tran, H. B., Cowper, A. E., Chotiyarnwon, P., et al. (2010) · Journal of Virology · doi:10.1128/jvi.01826-10 · Cited by 201 · see citing works
The Doctrine of Original Antigenic Sin: Separating Good From Evil
Monto, A. S., Malosh, R. E., Petrie, J. G., & Martin, E. T. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix173 · Cited by 180 · see citing works
Che, X., Qiu, L., Liao, Z., Wang, Y., Wen, K., Pan, Y., Hao, W., Mei, Y., Cheng, V. C., & Yuen, K. (2005) · The Journal of Infectious Diseases · doi:10.1086/430355 · Cited by 165 · see citing works
Prevalence of Antibodies to Four Human Coronaviruses Is Lower in Nasal Secretions than in Serum
Gorse, G. J., Patel, G. B., Vitale, J. N., & O’Connor, T. (2010) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00278-10 · Cited by 165 · see citing works
Gostic, K. M., Bridge, R., Brady, S., Viboud, C. G., Worobey, M., & Lloyd‐Smith, J. O. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008109 · Cited by 163 · see citing works
Ieven, M. M., Coenen, S., Loens, K., Lammens, C., Coenjaerts, F. E. J., Vanderstraeten, A., Henriques‐Normark, B., Crook, D. W., Huygen, K., Butler, C., et al. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.02.004 · Cited by 162 · see citing works
Elslande, J. V., Decru, B., Jonckheere, S., Wijngaerden, E. V., Houben, E., Vandecandelaere, P., Indevuyst, C., Depypere, M., Desmet, S., André, E., et al. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.07.038 · Cited by 142 · see citing works
Dugan, H. L., Guthmiller, J. J., Arevalo, P., Huang, M., Chen, Y.-Q., Neu, K. E., Henry, C., Zheng, N., Lan, L. Y.-L., Tepora, M. E., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abd3601 · Cited by 124 · see citing works
Self-citationSaletti, G., Gerlach, T. H., Jansen, J. M., Molle, A., Elbahesh, H., Ludlow, M., Li, W., Bosch, B., Osterhaus, A. D. M. E., & Rimmelzwaan, G. F. (2020) · Scientific Reports · doi:10.1038/s41598-020-78506-9 · Cited by 75 · see citing works
Meade, P. S., Kuan, G. M., Strohmeier, S., Maier, H. E., Amanat, F., Balmaseda, Á., Ito, K., Roubidoux, E. K., Javier, A., Gresh, L., et al. (2020) · mBio · doi:10.1128/mbio.03243-19 · Cited by 67 · see citing works
Self-citationInfluenza imprinting in childhood and the influence on vaccine response later in life
Kelvin, A. A., & Zambon, M. C. F. A. (2019) · Eurosurveillance · doi:10.2807/1560-7917.es.2019.24.48.1900720 · Cited by 57 · see citing works
Involvement of Aminopeptidase N (CD13) in Infection of Human Neural Cells by Human Coronavirus 229E
Lachance, C., Arbour, N., Cashman, N. R., & Talbot, P. J. (1998) · Journal of Virology · doi:10.1128/jvi.72.8.6511-6519.1998 · Cited by 48 · see citing works
Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 + T CellsPreprint
Meckiff, B. J., Ramírez-Suástegui, C., Fajardo, V., Chee, S., Kusnadi, A., Simon, H. A., Grifoni, A., Pelosi, E., Weiskopf, D., Sette, A., et al. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3641939 · Cited by 46 · see citing works
Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4 + T cellsPreprint
Meckiff, B. J., Ramírez-Suástegui, C., Fajardo, V., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.12.148916 · Cited by 45 · see citing works
Amanat, F., Thapa, M., Lei, T., Ahmed, S. M. S., Adelsberg, D. C., Carreño, J. M., Strohmeier, S., Schmitz, A. J., Zafar, S., Zhou, J. Q., et al. (2021) · medRxiv · doi:10.1101/2021.03.07.21253098 · Cited by 41 · see citing works
Self-citationAydillo, T., Escalera, A., Strohmeier, S., Aslam, S., Sánchez‐Céspedes, J., Ayllón, J., Roca-Oporto, C., Pérez‐Romero, P., Montejo, M., Gavaldà, J., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100130 · Cited by 30 · see citing works
Self-citationde Vries, R. D. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00338-w · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Adaptive immunity to SARS-CoV-2 and COVID-19
Sette, A., & Crotty, S. (2021) · Cell · doi:10.1016/j.cell.2021.01.007 · Cited by 1,860 · see citing works
Dispinseri, S., Secchi, M., Pirillo, M. F., Tolazzi, M., Borghi, M., Brigatti, C., Angelis, M. L. D., Baratella, M., Bazzigaluppi, E., Venturi, G., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22958-8 · Cited by 334 · see citing works
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response
Sokal, A., Chappert, P., Barba-Spaeth, G., Roeser, A., Fourati, S., Azzaoui, I., Vandenberghe, A., Fernandez, I., Meola, A., Bouvier-Alias, M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.050 · Cited by 340 · see citing works
SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2
Amanat, F., Thapa, M., Lei, T., Ahmed, S. M. S., Adelsberg, D. C., Carreño, J. M., Strohmeier, S., Schmitz, A. J., Zafar, S., Zhou, J. Q., et al. (2021) · Cell · doi:10.1016/j.cell.2021.06.005 · Cited by 273 · see citing works
Self-citationHumoral Responses and Serological Assays in SARS-CoV-2 Infections
Galipeau, Y., Greig, M., Liu, C., Driedger, M., & Langlois, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.610688 · Cited by 239 · see citing works
COVID-19 vaccination: The road ahead
Altmann, D. M., & Boyton, R. J. (2022) · Science · doi:10.1126/science.abn1755 · Cited by 195 · see citing works
Viral persistence, reactivation, and mechanisms of long COVID
Chen, B. K., Jülg, B. D., Mohandas, S., Bradfute, S. B., & RECOVER Mechanistic Pathways Task Force (2023) · eLife · doi:10.7554/elife.86015 · Cited by 195 · see citing works
T Cell Responses to SARS-CoV-2
Sette, A., Sidney, J., & Crotty, S. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101721-061120 · Cited by 181 · see citing works
Systems serology detects functionally distinct coronavirus antibody features in children and elderly
Selva, K. J., van de Sandt, C. E., Lemke, M. M., Lee, C. Y., Shoffner, S. K., Chua, B. Y. L., Davis, S. K., Nguyen, T. H. O., Rowntree, L. C., Hensen, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22236-7 · Cited by 172 · see citing works
Self-citationMutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission
Escalera, A., Gonzalez-Reiche, A. S., Aslam, S., Mena, I., Laporte, M., Pearl, R. L., Fossati, A., Rathnasinghe, R., Alshammary, H., van de Guchte, A., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.01.006 · Cited by 169 · see citing works
Self-citationImmunology of SARS-CoV-2 infection in children
Chou, J. S., Thomas, P. G., & Randolph, A. G. (2022) · Nature Immunology · doi:10.1038/s41590-021-01123-9 · Cited by 171 · see citing works
SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals
Sano, K., Bhavsar, D., Singh, G., Floda, D. L., Srivastava, K., Gleason, C., PARIS Study Group, Amoako, A. A., Andre, D., Beach, K. F., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32389-8 · Cited by 174 · see citing works
Self-citationOrtega, N., Ribes, M., Vidal, M., Rubio, R., Aguilar, R., Williams, S. V., Barrios, D., Alonso, S., Hernández-Luis, P., Mitchell, R. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24979-9 · Cited by 166 · see citing works
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants
Reynolds, C. J., Gibbons, J. M., Pade, C., Lin, K., Sandoval, D. M., Pieper, F. P., Butler, D. K., Liu, S., Otter, A. D., Joy, G., et al. (2022) · Science · doi:10.1126/science.abm0811 · Cited by 126 · see citing works
Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity
Aguilar-Bretones, M., Fouchier, R. A. M., Koopmans, M., & van Nierop, G. P. (2023) · Journal of Clinical Investigation · doi:10.1172/jci162192 · Cited by 104 · see citing works
Dobaño, C., Santano, R., Jiménez, A., Vidal, M., Chi, J., Melero, N. R., Popovic, M., López-Aladid, R., Fernández‐Barat, L., Tortajada, M., et al. (2021) · Translational research · doi:10.1016/j.trsl.2021.02.006 · Cited by 105 · see citing works
Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors
Zsichla, L., & Müller, V. (2023) · Viruses · doi:10.3390/v15010175 · Cited by 113 · see citing works
Lin, C.-Y., Wolf, J., Brice, D. C., Sun, Y., Locke, M., Cherry, S., Castellaw, A. H., Wehenkel, M., Crawford, J. C., Zarnitsyna, V. I., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.12.005 · Cited by 99 · see citing works
Cross-reactive antibodies after SARS-CoV-2 infection and vaccination
Grobben, M., van der Straten, K., Brouwer, P. J. M., Brinkkemper, M., Maisonnasse, P., Dereuddre‐Bosquet, N., Appelman, B., Lavell, A. H. A., van Vught, L. A., Burger, J. A., et al. (2021) · eLife · doi:10.7554/elife.70330 · Cited by 100 · see citing works
RETRACTED: SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies
Ng, K. W., Faulkner, N., Finsterbusch, K., Wu, M., Harvey, R., Hussain, S., Greco, M., Liu, Y., Kjær, S., Swanton, C., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn3715 · Cited by 95 · see citing works
RetractedImmune imprinting and SARS-CoV-2 vaccine design
Wheatley, A. K., Fox, A., Tan, H., Juno, J. A., Davenport, M. P., Subbarao, K., & Kent, S. J. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.09.001 · Cited by 93 · see citing works
Muena, N. A., García‐Salum, T., Pardo‐Roa, C., Avendaño, M. J., Serrano, E. F., Lévican, J., Almonacid, L. I., Valenzuela, G. H., Poblete, E., Strohmeier, S., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103972 · Cited by 85 · see citing works
Self-citationCross-protective immunity following coronavirus vaccination and coronavirus infection
Dangi, T., Palacio, N. M., Sanchez, S., Park, M., Class, J., Visvabharathy, L., Ciucci, T., Koralnik, I. J., Richner, J. M., & Penaloza-MacMaster, P. (2021) · Journal of Clinical Investigation · doi:10.1172/jci151969 · Cited by 78 · see citing works
Decay of Fc-dependent antibody functions after mild to moderate COVID-19
Lee, W. S., Selva, K. J., Davis, S. K., Wines, B. D., Reynaldi, A., Esterbauer, R., Kelly, H. G., Haycroft, E. R., Tan, H., Juno, J. A., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100296 · Cited by 78 · see citing works
Antunes, R. D. S., Pallikkuth, S., Williams, E., Yu, E. D., Mateus, J., Quiambao, L. G., Wang, E. W., Rawlings, S. A., Stadlbauer, D., Jiang, K., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab176 · Cited by 70 · see citing works
Self-citationVaccine-Associated Enhanced Disease and Pathogenic Human Coronaviruses
Gartlan, C., Tipton, T., Salguero, F. J., Sattentau, Q. J., GORRINGE, A. R., & Carroll, M. W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.882972 · Cited by 77 · see citing works
Aguilar-Bretones, M., Westerhuis, B. M., Raadsen, M. P., de Bruin, E., Chandler, F. D., Okba, N. M. A., Haagmans, B. L., Langerak, T., Endeman, H., van den Akker, J. P. C., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci150613 · Cited by 71 · see citing works
Structural mapping of antibody landscapes to human betacoronavirus spike proteins
Bangaru, S., Antanasijevic, A., Kose, N., Sewall, L. M., Jackson, A. M., Suryadevara, N., Zhan, X., Torres, J. L., Copps, J., de la Peña, A. T., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn2911 · Cited by 69 · see citing works
Immune imprinting and next-generation coronavirus vaccines
Huang, C. Q., Vishwanath, S., Carnell, G., Chan, A. C. Y., & Heeney, J. L. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01505-9 · Cited by 66 · see citing works
The role of vaccines in the COVID-19 pandemic: what have we learned?
Krammer, F. (2023) · Seminars in Immunopathology · doi:10.1007/s00281-023-00996-2 · Cited by 64 · see citing works
Self-citationCanaday, D. H., Oyebanji, O. A., White, E. M., Keresztesy, D., Payne, M., Wilk, D. J., Carias, L. L., Aung, H., Denis, K. S., Sheehan, M. L., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104066 · Cited by 57 · see citing works
Protective neutralizing epitopes in SARS‐CoV‐2
Liu, H., & Wilson, I. A. (2022) · Immunological Reviews · doi:10.1111/imr.13084 · Cited by 46 · see citing works
Crowley, A. R., Natarajan, H., Hederman, A. P., Bobak, C. A., Weiner, J. A., Wieland-Alter, W., Lee, J., Bloch, E. M., Tobian, A. A. R., Redd, A. D., et al. (2022) · eLife · doi:10.7554/elife.75228 · Cited by 49 · see citing works
Camerini, D., Randall, A., Trappl-Kimmons, K., Oberai, A., Hung, C., Edgar, J., Shandling, A., Huynh, V. T., Teng, A., Hermanson, G., et al. (2021) · medRxiv · doi:10.1128/spectrum.01416-21 · Cited by 30 · see citing works
COVID ‐19 and plasma cells: Is there long‐lived protection?*
Nguyen, D. C., Lamothe, P. A., Woodruff, M. C., Saini, A. S., Faliti, C. E., Sanz, I., & Lee, F. E.-H. (2022) · Immunological Reviews · doi:10.1111/imr.13115 · Cited by 44 · see citing works
de Gier, B., Huiberts, A. J., Hoeve, C. E., den Hartog, G., van Werkhoven, C. H., van Binnendijk, R. S., Hahné, S. J. M., de Melker, H. E., van den Hof, S., & Knol, M. J. (2023) · Nature Communications · doi:10.1038/s41467-023-40195-z · Cited by 46 · see citing works
Abela, I. A., Pasin, C., Schwarzmüller, M., Epp, S., Sickmann, M., Schanz, M., Rusert, P., Weber, J., Schmutz, S., Audigé, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27040-x · Cited by 44 · see citing works
Voss, W. N., Mallory, M. L., Byrne, P. O., Marchioni, J., Knudson, S. A., Powers, J. M., Leist, S. R., Dadonaite, B., Townsend, D. R., Kain, J., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101668 · Cited by 43 · see citing works
McNaughton, A. L., Paton, R. S., Edmans, M. D., Youngs, J., Wellens, J., Phalora, P. K., Fyfe, A. J., Belij‐Rammerstorfer, S., Bolton, J. S., Ball, J., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.156372 · Cited by 44 · see citing works
Circulating multimeric immune complexes contribute to immunopathology in COVID-19
Ankerhold, J., Giese, S., Kolb, P., Maul‐Pavicic, A., Voll, R. E., Göppert, N., Ciminski, K., Kreutz, C., Lother, A., Salzer, U., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32867-z · Cited by 43 · see citing works
Wekalao, J., Patel, S. K., Arun Kumar, U., Armghan, A., Kraiem, H., & Said, Y. (2024) · Plasmonics · doi:10.1007/s11468-024-02712-8 · Cited by 43 · see citing works
SARS-CoV-2—The Role of Natural Immunity: A Narrative Review
Diani, S., Leonardi, E. A., Cavezzi, A., Ferrari, S., Iacono, O., Limoli, A., Bouslenko, Z., Natalini, D., Conti, S., Mantovani, M., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216272 · Cited by 44 · see citing works
Cohen, L., Spiro, D. J., & Viboud, C. G. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010591 · Cited by 41 · see citing works
Amanat, F., Thapa, M., Lei, T., Ahmed, S. M. S., Adelsberg, D. C., Carreño, J. M., Strohmeier, S., Schmitz, A. J., Zafar, S., Zhou, J. Q., et al. (2021) · medRxiv · doi:10.1101/2021.03.07.21253098 · Cited by 41 · see citing works
Self-citationWaning immunity to SARS-CoV-2: implications for vaccine booster strategies
Altmann, D. M., & Boyton, R. J. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00458-6 · Cited by 39 · see citing works
Anderson, E. M., Li, S. H., Awofolaju, M., Eilola, T., Goodwin, E. C., Bolton, M. J., Gouma, S., Manzoni, T. B., Hicks, P. D., Goel, R. R., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111496 · Cited by 35 · see citing works
Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine
Wu, Y., Wang, S., Zhang, Y., Yuan, L., Zheng, Q., Wei, M., Shi, Y., Wang, Z., Ma, J., Wang, K., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.10.011 · Cited by 35 · see citing works
Khoo, W. H., Jackson, K., Phetsouphanh, C., Zaunders, J., Alquicira-Hernández, J., Yazar, S., Ruiz‐Diaz, S., Singh, M., Dhenni, R., Kyaw, W., et al. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109209 · Cited by 30 · see citing works
Pušnik, J., Zorn, J., Monzon‐Posadas, W. O., Peters, K., Osypchuk, E., Blaschke, S., & Streeck, H. (2024) · Nature Communications · doi:10.1038/s41467-024-47451-w · Cited by 36 · see citing works
Maltseva, M., Keeshan, A., Cooper, C., & Langlois, M. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2384192 · Cited by 33 · see citing works
Immune Imprinting and Implications for COVID-19
Zhou, Z., Barrett, J., & He, X. (2023) · Vaccines · doi:10.3390/vaccines11040875 · Cited by 31 · see citing works
King, S. M., Bryan, S. P., Hilchey, S. P., Wang, J., & Zand, M. S. (2023) · Pathogens · doi:10.3390/pathogens12020169 · Cited by 30 · see citing works
Spencer, A. J., Morris, S. J., Ulaszewska, M., Powers, C., Kailath, R., Bissett, C., Truby, A., Thakur, N., Newman, J., Allen, E. R., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103902 · Cited by 29 · see citing works
Seasonal respiratory virus circulation was diminished during the COVID‐19 pandemic
Heiskanen, A., Galipeau, Y., Little, J., Mortimer, L., Ramotar, K., Langlois, M., & Cooper, C. (2022) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.13065 · Cited by 29 · see citing works
Laing, E. D., Sterling, S. L., Richard, S. A., Epsi, N. J., Coggins, S. A., Samuels, E. C., Phogat, S., Yan, L., Moreno, N., Coles, C. L., et al. (2021) · medRxiv · doi:10.1101/2021.02.10.21251518 · Cited by 29 · see citing works
The “original antigenic sin” and its relevance for SARS-CoV-2 (COVID-19) vaccination
Rijkers, G. T., & van Overveld, F. J. (2021) · Clinical Immunology Communications · doi:10.1016/j.clicom.2021.10.001 · Cited by 27 · see citing works
McKimm‐Breschkin, J. L., Hay, A. J., Cao, B., Cox, R. J., Dunning, J. W., Moen, A. C., Olson, D., Pizzorno, A., & Hayden, F. G. (2021) · Antiviral Research · doi:10.1016/j.antiviral.2021.105227 · Cited by 29 · see citing works
Overview of the potential use of fluvoxamine for COVID-19 and long COVID
Hashimoto, K. (2023) · Discover Mental Health · doi:10.1007/s44192-023-00036-3 · Cited by 25 · see citing works
Viral kinetics of sequential SARS-CoV-2 infections
Kissler, S. M., Hay, J. A., Fauver, J. R., Mack, C. D., Tai, C. G.-L., Anderson, D. J., Ho, D. D., Grubaugh, N. D., & Grad, Y. H. (2023) · Nature Communications · doi:10.1038/s41467-023-41941-z · Cited by 27 · see citing works
How immunity from and interaction with seasonal coronaviruses can shape SARS-CoV-2 epidemiology
Waterlow, N. R., van Leeuwen, E., Davies, N. G., CMMID COVID-19 Working Group, Flasche, S., & Eggo, R. M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2108395118 · Cited by 26 · see citing works
Immune interference in effectiveness of influenza and COVID-19 vaccination
Xie, Y., Tian, X., Zhang, X., Yao, H., & Wu, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1167214 · Cited by 28 · see citing works
Li, F. F., Liu, A. C., Gibbs, E., Tanunliong, G., Marquez, A. C., Gantt, S. M., Frykman, H., Krajden, M., Morshed, M. G., Prystajecky, N., et al. (2021) · Journal of Clinical Virology · doi:10.1016/j.jcv.2021.105050 · Cited by 25 · see citing works
Loewen, S. M., Chavesa, A. M., Murray, C. J., Traetta, M. E., Burns, S. E., Pekarik, K. H., & Tremblay, M. (2023) · Developmental Neuroscience · doi:10.1159/000530185 · Cited by 25 · see citing works
Lawrenz, J., Xie, Q., Zech, F., Weil, T., Seidel, A., Krnavek, D., van der Hoek, L., Münch, J., Müller, J. A., & Kirchhoff, F. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciac057 · Cited by 25 · see citing works
Converting non-neutralizing SARS-CoV-2 antibodies into broad-spectrum inhibitors
Weidenbacher, P. A. B., Waltari, E., Kobara, I. D. L. R., Bell, B. N., Morris, M. K., Cheng, Y.-C., Hanson, C. V., Pak, J. E., & Kim, P. S. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01140-1 · Cited by 23 · see citing works
Immunological imprinting of humoral immunity to SARS-CoV-2 in children
Dowell, A. C., Lancaster, T., Bruton, R. K., Ireland, G., Bentley, C., Sylla, P., Zuo, J., Scott, S., Jadir, A., Begum, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39575-2 · Cited by 23 · see citing works
Immune interventions in COVID-19: a matter of time?
Plaçais, L., Richier, Q., Noël, N., Lacombe, K., Mariette, X., & Hermine, O. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00464-w · Cited by 22 · see citing works
Jaago, M., Rähni, A., Pupina, N., Pihlak, A., Sadam, H., Tuvikene, J., Avarlaid, A., Planken, A., Planken, M., Haring, L., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-20849-6 · Cited by 22 · see citing works
Castanha, P. M. S., Tuttle, D. J., Kitsios, G. D., Jacobs, J. L., Braga-Neto, U., Duespohl, M., Rathod, S., Martí, M. M., Wheeler, S., Naqvi, A., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac091 · Cited by 22 · see citing works
Noori, M., Nejadghaderi, S. A., & Rezaei, N. (2021) · Infection Control and Hospital Epidemiology · doi:10.1017/ice.2021.199 · Cited by 22 · see citing works
Coulon, P.-G. A., Prakash, S., Dhanushkodi, N. R., Srivastava, R., Zayou, L., Tifrea, D. F., Edwards, R. A., Figueroa, C. J., Schubl, S. D., Hsieh, L. L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1343716 · Cited by 19 · see citing works
He, X., Aïd, M., Chandrashekar, A., Yu, J., McMahan, K., Wegmann, F., Jacob-Dolan, C., Maron, J. S., Atyeo, C. G., Wan, H., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abm4996 · Cited by 21 · see citing works
Heterologous humoral immunity to human and zoonotic coronaviruses: Aiming for the achilles heel
Ng, K. W., Faulkner, N., Wrobel, A. G., Gamblin, S. J., & Kassiotis, G. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101507 · Cited by 19 · see citing works
Forgacs, D., Silva‐Moraes, V., Sautto, G. A., Hanley, H. B., Gattiker, J. L., Jefferson, A. M., Kolhe, R. B., & Ross, T. M. (2022) · Vaccines · doi:10.3390/vaccines10050696 · Cited by 21 · see citing works
Immune response induced by novel coronavirus infection
Sun, Y., Zou, Y., Wang, H., Cui, G.-Y., Yu, Z., & Ren, Z.-G. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.988604 · Cited by 14 · see citing works
Rational design of a booster vaccine against COVID-19 based on antigenic distance
Hu, Y., Yuen, T. T., Gong, H.-R., Hu, B., Hu, J., Lin, X., Li, R., Zhou, C. L., Chen, L., Wang, X., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.07.004 · Cited by 20 · see citing works
Herman, J. D., Atyeo, C. G., Zur, Y., Cook, C., Patel, N. J., Vanni, K. M. M., Kowalski, E., Qian, G., Srivatsan, S., Shadick, N. A., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adf6598 · Cited by 26 · see citing works
Evans, J. P., & Liu, S. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300315 · Cited by 19 · see citing works
Amanat, F., Clark, J. J., Carreño, J. M., Strohmeier, S., Yellin, T., Meade, P. S., Bhavsar, D., Muramatsu, H., Sun, W., Coughlan, L., et al. (2023) · Journal of Virology · doi:10.1128/jvi.01664-22 · Cited by 20 · see citing works
Self-citationPeddireddy, S. P., Rahman, S. A., Cillo, A. R., Vijay, G. K. M., Somasundaram, A., Workman, C. J., Bain, W., McVerry, B. J., Methé, B. A., Lee, J. S., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111020 · Cited by 19 · see citing works
Autoantibodies neutralizing type I IFNs in a fatal case of H5N1 avian influenza
Zhang, Q., Conrad, T. S., Moncada‐Vélez, M., Jiang, K., Čupić, A., Eaton, J., Hutchinson, K., Gervais, A., Chen, R., Puel, A., et al. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20251962 · Cited by 17 · see citing works
Self-citationDeliyannis, G., Gherardin, N. A., Wong, C. Y., Grimley, S. L., Cooney, J. P., Redmond, S. J., Ellenberg, P. C., Davidson, K. C., Mordant, F. L., Smith, T., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104574 · Cited by 17 · see citing works
SARS-CoV-2 infection induces robust mucosal antibody responses in the upper respiratory tract
Escalera, A., Rojo-Fernandez, A., Rombauts, A., Abelenda-Alonso, G., Carratalà, J., García‐Sastre, A., & Aydillo, T. (2024) · iScience · doi:10.1016/j.isci.2024.109210 · Cited by 16 · see citing works
Self-citationKang, C. K., Shin, H. M., Choe, P. G., Park, J., Hong, J., Seo, J. S., Lee, Y. H., Chang, E., Kim, M., Kim, M., et al. (2022) · BMC Medicine · doi:10.1186/s12916-022-02383-4 · Cited by 16 · see citing works
Emergent variant modeling of the serological repertoire to norovirus in young children
Lindesmith, L. C., Brewer-Jensen, P. D., Conrad, H., O’Reilly, K. M., Mallory, M. L., Kelly, D., Williams, R. J., Edmunds, W. J., Allen, D. J., Breuer, J., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.100954 · Cited by 15 · see citing works
Singh, G., Abbad, A., Kleiner, G., Srivastava, K., Gleason, C., PARIS Study Group, Carreño, J. M., Simon, V. R., Krammer, F., Andre, D., et al. (2023) · mBio · doi:10.1128/mbio.02250-23 · Cited by 16 · see citing works
Self-citationWietschel, K. A., Fechtner, K., Antileo, E., Abdurrahman, G., Drechsler, C. A., Makuvise, M. K., Rose, R., Voß, M., Krumbholz, A., Michalik, S., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1382911 · Cited by 15 · see citing works
Wang, J., Li, D., Cameron, A., Zhou, Q., Wiltse, A., Nayak, J. L., Pecora, N., & Zand, M. S. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac022 · Cited by 15 · see citing works
SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavagePreprint
Escalera, A., Gonzalez-Reiche, A. S., Aslam, S., Mena, I., Pearl, R. L., Laporte, M., Fossati, A., Rathnasinghe, R., Alshammary, H., van de Guchte, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.05.455290 · Cited by 15 · see citing works
Self-citationBurgio, S., de Macario, E. C., Macario, A. J. L., & Cappello, F. (2021) · Cell Stress and Chaperones · doi:10.1007/s12192-021-01211-7 · Cited by 14 · see citing works
A Complementary Union of SARS-CoV2 Natural and Vaccine Induced Immune Responses
Torresi, J., Edeling, M. A., Nolan, T. M., & Godfrey, D. I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.914167 · Cited by 15 · see citing works
Tunheim, G., Fossum, E., Robertson, A. H., Rø, G., Chopra, A., Vaage, J. T., Vikse, E. L., Kran, A. B., Magnus, P. M., Trogstad, L., et al. (2024) · BMC Infectious Diseases · doi:10.1186/s12879-024-09670-w · Cited by 13 · see citing works
Incomplete IgG avidity maturation after seasonal coronavirus infections
Struck, F., Schreiner, P. A., Staschik, E., Wochinz‐Richter, K., Schulz, S., Soutschek, E., Motz, M., & Bauer, G. (2021) · Journal of Medical Virology · doi:10.1002/jmv.27291 · Cited by 13 · see citing works
Vaccination after prior COVID-19 infection: Implications for dose sparing and booster shots
Kent, S. J., & Juno, J. A. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103586 · Cited by 13 · see citing works
Immune imprinting of SARS-CoV-2 responses: changing first immune impressions
Torresi, J., & Edeling, M. A. (2024) · mSphere · doi:10.1128/msphere.00758-23 · Cited by 12 · see citing works
Jiménez-Cabello, L., Utrilla-Trigo, S., Calvo-Pinilla, E., Lorenzo, G., Illescas-Amo, M., Benavides, J., Moreno, S., Marín-López, A., Nogales, A., & Ortego, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1440407 · Cited by 12 · see citing works
Deakin, C. T., Cornish, G. H., Ng, K. W., Faulkner, N., Bolland, W., Hope, J., Rosa, A., Harvey, R., Hussain, S., Earl, C. P., et al. (2021) · Med · doi:10.1016/j.medj.2021.08.001 · Cited by 12 · see citing works
Wang, J., Young, B. E., Li, D., Seppo, A., Zhou, Q., Wiltse, A., Nowak-Wegrzyn, A. H., Murphy, K., Widrick, K., Diaz, N., et al. (2022) · Vaccines · doi:10.3390/vaccines10060980 · Cited by 12 · see citing works
Yin, D., Han, Z., Lang, B., Li, Y., Mai, G., Chen, H., Feng, L., Chen, Y.-Q., Luo, H., Xiong, Y., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1195533 · Cited by 11 · see citing works
Olafsdottir, T. A., Bjarnadóttir, K., Norddahl, G. L., Halldorsson, G. H., Melsted, P., Gunnarsdóttir, K., Ivarsdottir, E. V., Ólafsdóttir, Þ., Arnthorsson, A. O., Theódórs, F., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03893-w · Cited by 11 · see citing works
- Authors
- Aydillo, T., Rombauts, A., Stadlbauer, D., Aslam, S., Abelenda-Alonso, G., Escalera, A., Amanat, F., Jiang, K., Krammer, F., Carratala, J., & García-Sastre, A.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Instituto de Salud Carlos III (ES)
- Corresponding author
- Krammer, Florian
- ORCID
- Venue
- Nature Communications
- Published
- 2021-06-18
- Volume
- 12
- Issue
- 1
- Pages
- 3781-3781
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC8213790
- OpenAlex
- W3171762393
- Cited by
- 223
- References
- 57
- Citations by year
- 2026: 14 · 2025: 24 · 2024: 25 · 2023: 46 · 2022: 69 · 2021: 44 · 2020: 1
- FWCI
- 14.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- ImmPort
- Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases (75N93019C00051)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- immunological imprinting, SARS-CoV-2, COVID-19 pandemic, antibody response, humoral immunity, seasonal coronaviruses, HCoV-OC43, HCoV-HKU1, 229E, spike protein, nucleocapsid protein, pre-existing immunity, IgG, IgM, hospitalized patients
- MeSH terms
- COVID-19, SARS-CoV-2, Aged, Antibodies, Viral, Antibody Formation, Cross Reactions, Female, Humans, Male, Spike Glycoprotein, Coronavirus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
