Milbrandt, Jeffrey

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

Araki, T., Sasaki, Y., & Milbrandt, J. (2004) · Science

Sirtuins and Resveratrol in MedicineNerve injury and regeneration

Cited by 1,060

Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme

Revollo, J. R., Körner, A., Mills, K. F., Satoh, A., Wang, T., Garten, A., Dasgupta, B., Sasaki, Y., Wolberger, C., Townsend, R. R., et al. (2007) · Cell Metabolism

Sirtuins and Resveratrol in MedicinePancreatic function and diabetes

Cited by 911

Resveratrol stimulates AMP kinase activity in neurons

Dasgupta, B., & Milbrandt, J. (2007) · Proceedings of the National Academy of Sciences

Sirtuins and Resveratrol in MedicineMetabolism, Diabetes, and Cancer

Cited by 723

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

Kotzbauer, P. T., Lampe, P. A., Heuckeroth, R. O., Golden, J. P., Creedon, D. J., Johnson Jr, E. M., & Milbrandt, J. (1996) · Nature

Nerve injury and regenerationNuclear Receptors and Signaling

Cited by 710

The SARM1 toll/interleukin-1 receptor domain possesses intrinsic NAD(+) cleavage activity that promotes pathological axonal degeneration

Essuman, K., Summers, D. W., Sasaki, Y., Mao, X., DiAntonio, A., & Milbrandt, J. (2017) · Neuron

Nerve injury and regenerationCell death mechanisms and regulation

Cited by 619

SARM1 activation triggers axon degeneration locally via NAD + destruction

Gerdts, J., Brace, E. J., Sasaki, Y., DiAntonio, A., & Milbrandt, J. (2015) · Science

Nerve injury and regenerationCell death mechanisms and regulation

Cited by 593

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

Figley, M. D., Gu, W., Nanson, J. D., Shi, Y., Sasaki, Y., Cunnea, K., Malde, A. K., Jia, X., Luo, Z., Saikot, F. K., et al. (2021) · Neuron

Sirtuins and Resveratrol in MedicineNerve injury and regeneration

Cited by 324

Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3

Tourtellotte, W. G., & Milbrandt, J. (1998) · Nature Genetics

Muscle Physiology and DisordersDevelopmental Biology and Gene Regulation

Cited by 306

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

Miller, B. R., Press, C., Daniels, R. W., Sasaki, Y., Milbrandt, J., & DiAntonio, A. (2009) · Nature Neuroscience

Nerve injury and regenerationNeurobiology and Insect Physiology Research

Cited by 301

Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy

Sasaki, Y., Araki, T., & Milbrandt, J. (2006) · The Journal of Neuroscience

Nerve injury and regenerationSirtuins and Resveratrol in Medicine

Cited by 269

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

Sasaki, Y., Nakagawa, T., Mao, X., DiAntonio, A., & Milbrandt, J. (2016) · eLife

Nerve injury and regenerationSirtuins and Resveratrol in Medicine

Cited by 192

Direct, Androgen Receptor-Mediated Regulation of the FKBP5 Gene via a Distal Enhancer Element

Magee, J. A., Chang, L.-W., Stormo, G. D., & Milbrandt, J. (2006) · Endocrinology

Prostate Cancer Treatment and ResearchGenomics and Chromatin Dynamics

Cited by 174

Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration In Vivo

Sasaki, Y., Vohra, B. P. S., Baloh, R. H., & Milbrandt, J. (2009) · The Journal of Neuroscience

Nerve injury and regenerationHereditary Neurological Disorders

Cited by 152

Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice

Crawford, P. A., Sadovsky, Y., Woodson, K., Lee, S. L., & Milbrandt, J. (1995) · Molecular and Cellular Biology

Adrenal Hormones and DisordersNuclear Receptors and Signaling

Cited by 145

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice

Geisler, S., Huang, S. X., Strickland, A., Doan, R. A., Summers, D. W., Mao, X., Park, J., DiAntonio, A., & Milbrandt, J. (2019) · Journal of Experimental Medicine

Nerve injury and regenerationHereditary Neurological Disorders

Cited by 145

Single-cell RNA-seq uncovers a robust transcriptional response to morphine by glia

Avey, D., Sankararaman, S., Yim, A. K. Y., Barve, R., Milbrandt, J., & Mitra, R. D. (2018) · Cell Reports

Single-cell and spatial transcriptomicsNeurotransmitter Receptor Influence on Behavior

Cited by 143

Feeding the brain and nurturing the mind: linking nutrition and the gut microbiota to brain development

Goyal, M. S., Venkatesh, S., Milbrandt, J., Gordon, J. I., & Raichle, M. E. (2015) · Proceedings of the National Academy of Sciences

Gut microbiota and healthInfant Nutrition and Health

Cited by 141

Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress

Press, C., & Milbrandt, J. (2008) · The Journal of Neuroscience

Nerve injury and regenerationHereditary Neurological Disorders

Cited by 137

Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage

Crawford, P. A., Sadovsky, Y., & Milbrandt, J. (1997) · Molecular and Cellular Biology

Pluripotent Stem Cells ResearchEstrogen and related hormone effects

Cited by 134

Unimpaired Macrophage Differentiation and Activation in Mice Lacking the Zinc Finger Transcription Factor NGFI-A (EGR1)

Lee, S. L., Wang, Y., & Milbrandt, J. (1996) · Molecular and Cellular Biology

Immune cells in cancerGenomics and Chromatin Dynamics

Cited by 93

Identification of Genes Induced in Peripheral Nerve after Injury

Araki, T., Nagarajan, R., & Milbrandt, J. (2001) · Journal of Biological Chemistry

Nerve injury and regenerationHereditary Neurological Disorders

Cited by 76

Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (NMNAT) protein transduction into transected axons

Sasaki, Y., & Milbrandt, J. (2010) · Journal of Biological Chemistry

Nerve injury and regenerationNeuroprotection in Cerebral Ischemia

Cited by 66

Identifying DNA-Binding Sites and Analyzing DNA-Binding Domains Using a Yeast Selection System

Liu, J., Wilson, T. E., Milbrandt, J., & Johnston, M. (1993) · Methods

Fungal and yeast genetics researchGenomics and Chromatin Dynamics

Cited by 54

Disruption of lactate metabolism in the peripheral nervous system leads to motor-selective deficits

Bloom, A. J., Hackett, A. R., Strickland, A., Yamada, Y., Ippolito, J., Schmidt, R. E., Sasaki, Y., DiAntonio, A., & Milbrandt, J. (2022) · Glia

Hereditary Neurological DisordersPeripheral Neuropathies and Disorders

Cited by 8