The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
Open accessAbstract
Stem cells can sort mitochondria by age: The renewal of tissues in aging organisms requires stem cells, which have the unusual ability to divide asymmetrically into one daughter cell that retains stem cell properties and another that differentiates into a particular tissue type. Katajisto et al. used photoactivated marker proteins to monitor the age of cell organelles in stemlike cells from human breast tissue and their distribution into daughter cells. Most organelles were evenly distributed, but daughter cells that maintained stem-cell properties received more newly produced mitochondria and fewer old ones. Science , this issue p. 340
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Cites
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
Vives-Bauza, C., Zhou, C., Huang, Y., Cui, M., de Vries, R. L. A., Kim, J., May, J., Tocilescu, M. A., Liu, W., Ko, H. S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911187107 · Cited by 1,616
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Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
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An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast
Hughes, A. L., & Gottschling, D. E. (2012) · Nature · doi:10.1038/nature11654 · Cited by 559
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
Okatsu, K., Saisho, K., Shimanuki, M., Nakada, K., Shitara, H., Sou, Y., Kimura, M., Sato, S., Hattori, N., Komatsu, M., et al. (2010) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01426.x · Cited by 397 · cited 1×
“Mitochondria that have lower membrane potential (ΔΨm)–an index of mitochondrial function– localize perinuclearly (18), and high ΔΨm is linked to stem-like traits (19, 20).”
BackgroundIncreased proteasome activity in human embryonic stem cells is regulated by PSMD11
Vilchez, D., Boyer, L., Morantte, I., Lutz, M., Merkwirth, C., Joyce, D., Spencer, B., Page, L., Masliah, E., Berggren, W. T., et al. (2012) · Nature · doi:10.1038/nature11468 · Cited by 388
Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo
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Cited by
Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
Pickles, S., Vigié, P., & Youle, R. J. (2018) · Current Biology · doi:10.1016/j.cub.2018.01.004 · Cited by 2,081
Cancer metabolism: a therapeutic perspective
Martinez-Outschoorn, U. E., Peiris-Pagés, M., Pestell, R. G., Sotgia, F., & Lisanti, M. P. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.60 · Cited by 1,505
The mitochondrial basis of aging
Sun, N., Youle, R. J., & Finkel, T. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.028 · Cited by 1,441
Mitochondrial Dynamics and Its Involvement in Disease
Chan, D. C. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032711 · Cited by 1,416
NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice
Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255
Metadata
- Authors
- Katajisto, P., Döhla, J., Chaffer, C. L., Pentinmikko, N., Marjanovic, N., Iqbal, S., Zoncu, R., Chen, W., Weinberg, R. A., & Sabatini, D. M.
- Venue
- Science
- Published
- 2015-04-17
- Volume
- 348
- Issue
- 6232
- Pages
- 340-343
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997982747
- Cited by
- 541
- References
- 7
- FWCI
- 24.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Katajisto, P., Döhla, J., Chaffer, C. L., Pentinmikko, N., Marjanovic, N., Iqbal, S., Zoncu, R., Chen, W., Weinberg, R. A., & Sabatini, D. M. (2015). Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Science. https://doi.org/10.1126/science.1260384
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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