Cited by 254Epigenetics and DNA MethylationGenomics and Chromatin DynamicsNuclear Structure and Function

Restricted epigenetic inheritance of H3K9 methylation

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Audergon, Pauline N. C. B., Catania, Sandra, Kagansky, Alexander, Tong, Pin, Shukla, Manu, Pidoux, Alison L., Allshire, Robin C.·2015·Science

Abstract

Inheritance of a covalent histone modification: Genomic DNA is the repository of all genetic information and is packaged into chromatin. Chromatin is also a repository of regulatory information in the form of covalent marks added to the histones that package the DNA. These marks can determine tissue- and organ-specific gene expression patterns, which must be transmitted to daughter cells to maintain their identity. Ragunathan et al. and Audergon et al. show that in fission yeast, a chromatin mark, like genetic information, can be inherited across many cell generations. The mark can be inherited independently of DNA sequence, DNA methylation, or RNA interference. Thus, histone marks constitute true epigenetic information. Science , this issue 10.1126/science.1258699 ; see also p. 132

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  • Inherited epigenetic patterns and environmental factors other than childhood trauma may impact the epigenetic pattern and hence childhood trauma-induced differential health outcomes.

    “Indeed, inherited epigenetic patterns (254–256) and environmental factors (257, 258) other than childhood trauma (such as heavy metals (259), parenting style, and early trauma such as maternal separation (260)) may all impact the epigenetic pattern and hence childhood trauma-induced differential health outcomes.”

    From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [256]

    The Abstract reports that H3K9 methylation can persist through mitotic divisions and meiosis in fission yeast when Epe1 is inactivated, supporting the inherited-epigenetic-patterns part of the citation. It also says active removal normally prevents that inheritance. The paper does not connect this mechanism to childhood trauma or differential health outcomes. (LLM, conf=0.84)

    Experimental — accuracy not yet measured
  • Without RNAi-dependent amplification, H3K9me3 alone is insufficient for stable epigenetic memory unless Epe1 is mutated.

    “By contrast, in the absence of RNAi-dependent amplification, H3K9me3 alone is insufficient to drive stable epigenetic memory, unless the histone demethylase Epe1 is mutated 47,102 .”
  • Yeast transgenerational epigenetic inheritance involves RNAi-dependent heterochromatin deposition leading to Clr4-dependent H3K9me3 marking of silent heterochromatin.

    “In yeast, TEI has been well-documented 101 and is known to involve RNAi-dependent heterochromatin deposition, leading to Clr4dependent H3K9me3 marking of silent heterochromatin 47,102 .”

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Authors
Audergon, P. N. C. B., Catania, S., Kagansky, A., Tong, P., Shukla, M., Pidoux, A. L., & Allshire, R. C.
Affiliations
Wellcome Centre for Cell Biology (GB)
Corresponding author
Allshire, Robin C.
Venue
Science
Published
2015-04-03
Volume
348
Issue
6230
Pages
132-135
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2105077884
Cited by
254
References
32
Citations by year
2026: 14 · 2025: 10 · 2024: 29 · 2023: 20 · 2022: 21 · 2021: 23 · 2020: 26 · 2019: 22 · 2018: 15 · 2017: 35 · 2016: 26 · 2015: 13
FWCI
12.88
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • ERA (submittedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders
  • Wellcome Trust (93852)
  • Wellcome Trust Principal Research Fellowship (95021)
  • EC-NOE-EpiGeneSys (HEALTH-F4-2010-257082)
  • Wellcome Trust Centre for Cell Biology (92076)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords
H3K9 methylation, epigenetic inheritance, heterochromatin, Clr4, histone demethylase, histone methyltransferase, transgenerational inheritance, meiosis, mitotic inheritance, Schizosaccharomyces pombe
MeSH terms
Heterochromatin, Histones, Lysine, Methylation, Methyltransferases, Mutation, Nuclear Proteins, Histone-Lysine N-Methyltransferase, Protein Processing, Post-Translational, Schizosaccharomyces, Cell Cycle Proteins, Schizosaccharomyces pombe Proteins, Epigenesis, Genetic

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