Restricted epigenetic inheritance of H3K9 methylation
Open accessAbstract
Inheritance of a covalent histone modification: Genomic DNA is the repository of all genetic information and is packaged into chromatin. Chromatin is also a repository of regulatory information in the form of covalent marks added to the histones that package the DNA. These marks can determine tissue- and organ-specific gene expression patterns, which must be transmitted to daughter cells to maintain their identity. Ragunathan et al. and Audergon et al. show that in fission yeast, a chromatin mark, like genetic information, can be inherited across many cell generations. The mark can be inherited independently of DNA sequence, DNA methylation, or RNA interference. Thus, histone marks constitute true epigenetic information. Science , this issue 10.1126/science.1258699 ; see also p. 132
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Inherited epigenetic patterns and environmental factors other than childhood trauma may impact the epigenetic pattern and hence childhood trauma-induced differential health outcomes.
“Indeed, inherited epigenetic patterns (254–256) and environmental factors (257, 258) other than childhood trauma (such as heavy metals (259), parenting style, and early trauma such as maternal separation (260)) may all impact the epigenetic pattern and hence childhood trauma-induced differential health outcomes.”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [256]
The Abstract reports that H3K9 methylation can persist through mitotic divisions and meiosis in fission yeast when Epe1 is inactivated, supporting the inherited-epigenetic-patterns part of the citation. It also says active removal normally prevents that inheritance. The paper does not connect this mechanism to childhood trauma or differential health outcomes. (LLM, conf=0.84)
Experimental — accuracy not yet measuredWithout RNAi-dependent amplification, H3K9me3 alone is insufficient for stable epigenetic memory unless Epe1 is mutated.
“By contrast, in the absence of RNAi-dependent amplification, H3K9me3 alone is insufficient to drive stable epigenetic memory, unless the histone demethylase Epe1 is mutated 47,102 .”
From Advances in epigenetics link genetics to the environment and disease (2019) · cites this paper as [102]
Yeast transgenerational epigenetic inheritance involves RNAi-dependent heterochromatin deposition leading to Clr4-dependent H3K9me3 marking of silent heterochromatin.
“In yeast, TEI has been well-documented 101 and is known to involve RNAi-dependent heterochromatin deposition, leading to Clr4dependent H3K9me3 marking of silent heterochromatin 47,102 .”
From Advances in epigenetics link genetics to the environment and disease (2019) · cites this paper as [102]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051 · see citing works
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
Bannister, A. J., Zegerman, P., Partridge, J. F., Miska, E. A., Thomas, J. O., Allshire, R. C., & Kouzarides, T. (2001) · Nature · doi:10.1038/35065138 · Cited by 2,903 · see citing works
Self-citationMethylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868 · see citing works
Histone demethylation by a family of JmjC domain-containing proteins
Tsukada, Y.-I., Fang, J., Erdjument‐Bromage, H., Warren, M., Borchers, C. H., Tempst, P., & Zhang, Y. (2005) · Nature · doi:10.1038/nature04433 · Cited by 2,171 · see citing works
Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly
Nakayama, J.-I., Rice, J. C., Strahl, B. D., Allis, C. D., & Grewal, S. I. S. (2001) · Science · doi:10.1126/science.1060118 · Cited by 1,739 · see citing works
RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond
Castel, S. E., & Martienssen, R. A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3355 · Cited by 977 · see citing works
Dynamics and Memory of Heterochromatin in Living Cells
Hathaway, N. A., Bell, O., Hodges, C., Miller, E. L., Neel, D. S., & Crabtree, G. R. (2012) · Cell · doi:10.1016/j.cell.2012.03.052 · Cited by 446 · see citing works
Aagaard, L., Laible, G., Selenko, P., Schmid, M., Dorn, R., Schotta, G., Kuhfittig, S., Wolf, A., Lebersorger, A., Singh, P. B., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1923 · Cited by 441 · see citing works
Zhang, K., Mosch, K., Fischle, W., & Grewal, S. I. S. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1406 · Cited by 389 · see citing works
Cell cycle control of centromeric repeat transcription and heterochromatin assembly
Chen, E. S., Zhang, K., Nicolas, E., Cam, H. P., Zofall, M., & Grewal, S. I. S. (2008) · Nature · doi:10.1038/nature06561 · Cited by 356 · see citing works
RNAi-Independent Heterochromatin Nucleation by the Stress-Activated ATF/CREB Family Proteins
Jia, S., Noma, K.-I., & Grewal, S. I. S. (2004) · Science · doi:10.1126/science.1099035 · Cited by 324 · see citing works
RNA Interference Guides Histone Modification during the S Phase of Chromosomal Replication
Kloc, A., Zaratiegui, M., Nora, E. P., & Martienssen, R. A. (2008) · Current Biology · doi:10.1016/j.cub.2008.03.016 · Cited by 242 · see citing works
RNA Elimination Machinery Targeting Meiotic mRNAs Promotes Facultative Heterochromatin Formation
Zofall, M., Yamanaka, S., Reyes‐Turcu, F. E., Zhang, K., Rubin, C., & Grewal, S. I. S. (2011) · Science · doi:10.1126/science.1211651 · Cited by 213 · see citing works
PKA-dependent regulation of the histone lysine demethylase complex PHF2–ARID5B
Baba, A., Ohtake, F., Okuno, Y., Yokota, K., Okada, M., Imai, Y., Ni, M., Meyer, C. A., Igarashi, K., Kanno, J., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2228 · Cited by 200 · see citing works
Swi6/HP1 Recruits a JmjC Domain Protein to Facilitate Transcription of Heterochromatic Repeats
Zofall, M., & Grewal, S. I. S. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.010 · Cited by 189 · see citing works
Kinetochore geometry defined by cohesion within the centromere
Sakuno, T., Tada, K., & Watanabe, Y. (2009) · Nature · doi:10.1038/nature07876 · Cited by 175 · see citing works
Synthetic Heterochromatin Bypasses RNAi and Centromeric Repeats to Establish Functional Centromeres
Kagansky, A., Folco, H. D., Almeida, R., Pidoux, A. L., Boukaba, A., Simmer, F., Urano, T., Hamilton, G. L., & Allshire, R. C. (2009) · Science · doi:10.1126/science.1172026 · Cited by 159 · see citing works
Self-citationA Novel jmjC Domain Protein Modulates Heterochromatization in Fission Yeast
Ayoub, N., Noma, K.-I., Isaac, S., Kahan, T., Grewal, S. I. S., & Cohen, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.12.4356-4370.2003 · Cited by 143 · see citing works
Regulation of replication timing in fission yeast
Kim, S.-M., & Huberman, J. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.6115 · Cited by 136 · see citing works
Structural and Functional Coordination of DNA and Histone MethylationPreprint
Cheng, X. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018747 · Cited by 119 · see citing works
Recombination-induced tag exchange to track old and new proteins
Verzijlbergen, K. F., Menéndez-Benito, V., van Welsem, T., van Deventer, S. J., Lindstrom, D. L., Ovaa, H., Neefjes, J., Gottschling, D. E., & van Leeuwen, F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911164107 · Cited by 105 · see citing works
Heterochromatin maintenance and establishment: Lessons from the mouse pericentromere
Almouzni, G., & Probst, A. V. (2011) · Nucleus · doi:10.4161/nucl.2.5.17707 · Cited by 104 · see citing works
Epigenetic inheritance: uncontested
Zhu, B., & Reinberg, D. (2011) · Cell Research · doi:10.1038/cr.2011.26 · Cited by 100 · see citing works
Braun, S. J., Garcia, J. F., Rowley, M., Rougemaille, M., Shankar, S., & Madhani, H. D. (2011) · Cell · doi:10.1016/j.cell.2010.11.051 · Cited by 96 · see citing works
The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin
Trewick, S. C., Minc, E., Antonelli, R., Urano, T., & Allshire, R. C. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601892 · Cited by 95 · see citing works
Self-citationReyes‐Turcu, F. E., & Grewal, S. I. S. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.12.004 · Cited by 81 · see citing works
Histone lysine methylation and chromatin replication
Rivera, C., Gurard‐Levin, Z. A., Almouzni, G., & Loyola, A. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.03.009 · Cited by 80 · see citing works
Buscaino, A., Lejeune, E., Audergon, P. N. C. B., Hamilton, G., Pidoux, A. L., & Allshire, R. C. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.72 · Cited by 77 · see citing works
Self-citationCrystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3
Wang, T., Xu, C., Liu, Y., Fan, K., Li, Z., Sun, X. W., Ouyang, H., Zhang, X., Zhang, J., Li, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052977 · Cited by 71 · see citing works
Jacobs, S. A., Fischle, W., & Khorasanizadeh, S. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)76009-1 · Cited by 47 · see citing works
Wheeler, B. S., Ruderman, B. T., Willard, H. F., & Scott, K. C. (2011) · Genetics · doi:10.1534/genetics.111.137083 · Cited by 16 · see citing works
Flagged first, then by citations
1 of the 32 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The molecular hallmarks of epigenetic control
Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809 · see citing works
Advances in epigenetics link genetics to the environment and disease
Cavalli, G., & Heard, E. (2019) · Nature · doi:10.1038/s41586-019-1411-0 · Cited by 1,509 · see citing works
Epigenetic plasticity and the hallmarks of cancer
Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340 · see citing works
Lämke, J., & Bäurle, I. (2017) · Genome biology · doi:10.1186/s13059-017-1263-6 · Cited by 914 · see citing works
Ten principles of heterochromatin formation and function
Allshire, R. C., & Madhani, H. D. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.119 · Cited by 783 · see citing works
Self-citationGenome-wide programmable transcriptional memory by CRISPR-based epigenome editing
Nuñez, J. K., Chen, J., Pommier, G. C., Cogan, J. Z., Replogle, J. M., Adriaens, C., Ramadoss, G. N., Shi, Q., Hung, K. L., Samelson, A. J., et al. (2021) · Cell · doi:10.1016/j.cell.2021.03.025 · Cited by 760 · see citing works
Molecular mechanisms of transgenerational epigenetic inheritance
Fitz-James, M. H., & Cavalli, G. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-021-00438-5 · Cited by 589 · see citing works
Ecological plant epigenetics: Evidence from model and non‐model species, and the way forward
Richards, C. L., Alonso, C., Becker, C., Bossdorf, O., Bucher, E., Colomé‐Tatché, M., Durka, W., Engelhardt, J., Gáspár, B. K., Gogol‐Döring, A., et al. (2017) · Ecology Letters · doi:10.1111/ele.12858 · Cited by 352 · see citing works
Epigenetic inheritance and the missing heritability
Trerotola, M., Relli, V., Simeone, P., & Alberti, S. (2015) · Human Genomics · doi:10.1186/s40246-015-0041-3 · Cited by 318 · see citing works
Role of H3K9me3 heterochromatin in cell identity establishment and maintenance
Nicetto, D., & Zaret, K. S. (2019) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2019.04.013 · Cited by 312 · see citing works
CRISPR/Cas9-based engineering of the epigenome
Pulecio, J., Verma, N., Mejía-Ramírez, E., Huangfu, D., & Raya, A. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.09.006 · Cited by 300 · see citing works
Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma
Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00808 · Cited by 288 · see citing works
Innate immune memory: An evolutionary perspective
Gourbal, B., Pinaud, S., Beckers, G. J. M., van der Meer, J. W. M., Conrath, U., & Netea, M. G. (2018) · Immunological Reviews · doi:10.1111/imr.12647 · Cited by 283 · see citing works
Chromatin replication and epigenetic cell memory
Stewart-Morgan, K. R., Petryk, N., & Groth, A. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0487-y · Cited by 281 · see citing works
PRC2 is high maintenancePreprint
Yu, J.-R., Lee, C., Oksuz, O., Stafford, J. M., & Reinberg, D. (2019) · Genes & Development · doi:10.1101/gad.325050.119 · Cited by 248 · see citing works
Reverón-Gómez, N., González‐Aguilera, C., Stewart-Morgan, K. R., Petryk, N., Flury, V., Graziano, S., Johansen, J. V., Jakobsen, J. S., Alabert, C., & Groth, A. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.08.010 · Cited by 239 · see citing works
Histone demethylases in chromatin biology and beyond
Dimitrova, E., Turberfield, A. H., & Klose, R. J. (2015) · EMBO Reports · doi:10.15252/embr.201541113 · Cited by 236 · see citing works
Causal role for inheritance of H3K27me3 in maintaining the OFF state of a <i>Drosophila</i> HOX gene
Coleman, R. T., & Struhl, G. (2017) · Science · doi:10.1126/science.aai8236 · Cited by 221 · see citing works
The molecular basis of heterochromatin assembly and epigenetic inheritance
Grewal, S. I. S. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.04.020 · Cited by 210 · see citing works
Epigenome Editing: State of the Art, Concepts, and Perspectives
Kungulovski, G., & Jeltsch, A. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.12.001 · Cited by 208 · see citing works
Wang, Y., Liu, H., & Sun, Z. S. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12322 · Cited by 192 · see citing works
Propagation of Polycomb-repressed chromatin requires sequence-specific recruitment to DNA
Laprell, F., Finkl, K., & Müller, J. (2017) · Science · doi:10.1126/science.aai8266 · Cited by 188 · see citing works
Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery
Sienski, G., Batki, J., Senti, K.-A., Dönertas, D., Tirian, L., Meixner, K., & Brennecke, J. (2015) · Genes & Development · doi:10.1101/gad.271908.115 · Cited by 185 · see citing works
Principles of Transgenerational Small RNA Inheritance in Caenorhabditis elegans
Rechavi, O., & Lev, I. (2017) · Current Biology · doi:10.1016/j.cub.2017.05.043 · Cited by 163 · see citing works
Epigenetic Control of Defense Signaling and Priming in Plants
Espinas, N. A., Saze, H., & Saijo, Y. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01201 · Cited by 160 · see citing works
Super-enhancers in transcriptional regulation and genome organization
Wang, X., Cairns, M. J., & Yan, J. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1038 · Cited by 154 · see citing works
Adaptation to environmental stress at different timescales
Kristensen, T. N., Ketola, T., & Kronholm, I. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13974 · Cited by 139 · see citing works
New Insights into the Regulation of Heterochromatin
Wang, J., Jia, S. T., & Jia, S. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.02.005 · Cited by 140 · see citing works
Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation
Yu, R., Wang, X., & Moazed, D. (2018) · Nature · doi:10.1038/s41586-018-0239-3 · Cited by 128 · see citing works
Epigenetic gene silencing by heterochromatin primes fungal resistance
Torres-Garcia, S., Yaseen, I., Shukla, M. S., Audergon, P. N. C. B., White, S. A., Pidoux, A. L., & Allshire, R. C. (2020) · Nature · doi:10.1038/s41586-020-2706-x · Cited by 128 · see citing works
Self-citationDNA sequence-dependent epigenetic inheritance of gene silencing and histone H3K9 methylation
Wang, X., & Moazed, D. (2017) · Science · doi:10.1126/science.aaj2114 · Cited by 117 · see citing works
Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription
Jih, G. T., Iglesias, N., Currie, M. A., Bhanu, N. V., Paulo, J. A., Gygi, S. P., Garcia, B. A., & Moazed, D. (2017) · Nature · doi:10.1038/nature23267 · Cited by 121 · see citing works
Zhao, J., Wang, M., Chang, L., Yu, J., Song, A., Liu, C., Huang, W., Zhang, T., Wu, X., Shen, X., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0484-1 · Cited by 114 · see citing works
Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2Preprint
Barrales, R. R., Forn, M., Georgescu, P. R., Sarkadi, Z., & Braun, S. J. (2016) · Genes & Development · doi:10.1101/gad.271288.115 · Cited by 113 · see citing works
Iglesias, N., Paulo, J. A., Tatarakis, A., Wang, X., Edwards, A., Bhanu, N. V., Garcia, B. A., Haas, W., Gygi, S. P., & Moazed, D. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.018 · Cited by 107 · see citing works
Parental nucleosome segregation and the inheritance of cellular identity
Escobar, T. M., Loyola, A., & Reinberg, D. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-020-00312-w · Cited by 106 · see citing works
Engineering Epigenetic Regulation Using Synthetic Read-Write Modules
Park, M., Patel, N., Keung, A. J., & Khalil, A. S. (2018) · Cell · doi:10.1016/j.cell.2018.11.002 · Cited by 103 · see citing works
Holla, S., Dhakshnamoorthy, J., Folco, H. D., Balachandran, V., Xiao, H., Sun, L., Wheeler, D. L., Zofall, M., & Grewal, S. I. S. (2019) · Cell · doi:10.1016/j.cell.2019.12.004 · Cited by 102 · see citing works
Epigenetic and Genetic Contributions to Adaptation in Chlamydomonas
Kronholm, I., Bassett, A. R., Baulcombe, D. C., & Collins, S. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx166 · Cited by 99 · see citing works
Green algal molecular responses to temperature stress
Barati, B., Gan, S. Y., Lim, P. E., Beardall, J., & Phang, S. (2019) · Acta Physiologiae Plantarum · doi:10.1007/s11738-019-2813-1 · Cited by 98 · see citing works
A Prion Epigenetic Switch Establishes an Active Chromatin State
Harvey, Z. H., Chakravarty, A. K., Futia, R. A., & Jarosz, D. F. (2019) · Cell · doi:10.1016/j.cell.2020.02.014 · Cited by 86 · see citing works
Taneja, N., Zofall, M., Balachandran, V., Thillainadesan, G., Sugiyama, T., Wheeler, D. L., Zhou, M., & Grewal, S. I. S. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.02.006 · Cited by 91 · see citing works
Shirai, A., Kawaguchi, T., Shimojo, H., Muramatsu, D., Ishida-Yonetani, M., Nishimura, Y., Kimurâ, H., Nakayama, J., & Shinkai, Y. (2017) · eLife · doi:10.7554/elife.25317 · Cited by 88 · see citing works
Wenger, A., Biran, A., Alcaraz, N., Riveiro, A. R., Sell, A. C., Krautz, R., Flury, V., Reverón-Gómez, N., Solis‐Mezarino, V., Völker-Albert, M. C., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01476-x · Cited by 82 · see citing works
Jost, D., & Vaillant, C. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky009 · Cited by 84 · see citing works
Mechanisms, timescales and principles of trans-generational epigenetic inheritance in animals
Kłosin, A., & Lehner, B. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.04.001 · Cited by 82 · see citing works
A cis-acting mechanism mediates transcriptional memory at Polycomb target genes in mammals
Holoch, D., Wassef, M. A., Lövkvist, C., Zielinski, D., Aflaki, S., Lombard, B., Héry, T., Loew, D., Howard, M., & Margueron, R. (2021) · Nature Genetics · doi:10.1038/s41588-021-00964-2 · Cited by 79 · see citing works
A Relay Race on the Evolutionary Adaptation Spectrum
Yona, A. H., Frumkin, I., & Pilpel, Y. (2015) · Cell · doi:10.1016/j.cell.2015.10.005 · Cited by 79 · see citing works
Cutter, A. R., Taneja, N., Dhakshnamoorthy, J., Wheeler, D. L., Holla, S., & Grewal, S. I. S. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100699118 · Cited by 82 · see citing works
Veazey, K. J., Parnell, S. E., Miranda, R. C., & Golding, M. C. (2015) · Epigenetics & Chromatin · doi:10.1186/s13072-015-0031-7 · Cited by 81 · see citing works
Kalinava, N., Ni, J. Z., Peterman, K., Chen, E., & Gu, S. G. (2017) · Epigenetics & Chromatin · doi:10.1186/s13072-017-0114-8 · Cited by 77 · see citing works
Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells
Cuvier, O., & Fierz, B. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.28 · Cited by 75 · see citing works
Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
Moussa, H. F., Bsteh, D., Yelagandula, R., Pribitzer, C., Stecher, K., Bartalska, K., Michetti, L., Wang, J., Zepeda-Martinez, J. A., Elling, U., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09628-6 · Cited by 75 · see citing works
Empirical evidence for epigenetic inheritance driving evolutionary adaptation
Stajic, D., & Jansen, L. E. T. (2021) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2020.0121 · Cited by 74 · see citing works
Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability
Iglesias, N., Currie, M. A., Jih, G. T., Paulo, J. A., Siuti, N., Kalocsay, M., Gygi, S. P., & Moazed, D. (2018) · Nature · doi:10.1038/s41586-018-0398-2 · Cited by 71 · see citing works
Sadeghi, L., Prasad, P., Ekwall, K., Cohen, A., & Svensson, J. P. (2015) · EMBO Reports · doi:10.15252/embr.201541214 · Cited by 70 · see citing works
Use of BABA and INA As Activators of a Primed State in the Common Bean (Phaseolus vulgaris L.)
Martínez-Aguilar, K., Ramírez-Carrasco, G., Hernández-Chávez, J. L., Barraza, A., & Álvarez-Venegas, R. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00653 · Cited by 68 · see citing works
Lee, T. W.-S., David, H. S., Engstrom, A., Carpenter, B. S., & Katz, D. J. (2019) · eLife · doi:10.7554/elife.48498 · Cited by 63 · see citing works
Epigenetic gene regulation by histone demethylases: emerging role in oncogenesis and inflammation
Kang, M., Mehrazarin, S., Park, N., & Wang, C. (2016) · Oral Diseases · doi:10.1111/odi.12569 · Cited by 61 · see citing works
The epigenetically-encoded memory of the innate immune system
Sun, S., & Barreiro, L. B. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.02.002 · Cited by 60 · see citing works
SpEDIT: A fast and efficient CRISPR/Cas9 method for fission yeast
Torres-Garcia, S., di Pompeo, L., Eivers, L., Gaborieau, B., White, S. A., Pidoux, A. L., Kanigowska, P., Yaseen, I., Cai, Y., & Allshire, R. C. (2020) · Wellcome Open Research · doi:10.12688/wellcomeopenres.16405.1 · Cited by 56 · see citing works
Self-citationNucleation and spreading of a heterochromatic domain in fission yeast
Obersriebnig, M. J., Pallesen, E. M. H., Sneppen, K., Trusina, A., & Thon, G. (2016) · Nature Communications · doi:10.1038/ncomms11518 · Cited by 56 · see citing works
Meller, B., Kuźnicki, D., Arasimowicz‐Jelonek, M., Deckert, J., & Floryszak‐Wieczorek, J. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.01228 · Cited by 58 · see citing works
Generalized nucleation and looping model for epigenetic memory of histone modifications
Erdel, F., & Greene, E. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605862113 · Cited by 56 · see citing works
Mechanisms of chromatin-based epigenetic inheritance
Du, W., Shi, G., Shan, C., Li, Z., Zhu, B., Jia, S., Li, Q., & Zhang, Z. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2120-1 · Cited by 53 · see citing works
The fork protection complex promotes parental histone recycling and epigenetic memory
Charlton, S. J., Flury, V., Kanoh, Y., Genzor, A. V., Kollenstart, L., Ao, W., Brøgger, P., Weisser, M. B., Adamus, M., Alcaraz, N., et al. (2024) · Cell · doi:10.1016/j.cell.2024.07.017 · Cited by 56 · see citing works
A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance
Yu, J., Zhang, Y., Fang, Y., Paulo, J. A., Yaghoubi, D., Hua, X., Shipkovenska, G. G., Toda, T., Zhang, Z., Gygi, S. P., et al. (2024) · Cell · doi:10.1016/j.cell.2024.07.006 · Cited by 56 · see citing works
Chromatin Replication and Histone Dynamics
Alabert, C., Jasencakova, Z., & Groth, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6955-0_15 · Cited by 54 · see citing works
Control of mesenchymal stem cell biology by histone modifications
Ren, J., Huang, D., Li, R., Wang, W., & Zhou, C. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-0378-8 · Cited by 54 · see citing works
The epigenome: the next substrate for engineering
Park, M., Keung, A. J., & Khalil, A. S. (2016) · Genome biology · doi:10.1186/s13059-016-1046-5 · Cited by 52 · see citing works
Human endogenous retroviruses in cancer: Expression, regulation and function (Review)
Gao, Y., Yu, X., & Chen, T. (2020) · Oncology Letters · doi:10.3892/ol.2020.12382 · Cited by 52 · see citing works
The Genetics of Epigenetic Inheritance: Modes, Molecules, and Mechanisms
Schaefer, S., & Nadeau, J. H. (2015) · The Quarterly Review of Biology · doi:10.1086/683699 · Cited by 50 · see citing works
Epigenetic memory independent of symmetric histone inheritance
Saxton, D. S., & Rine, J. (2019) · eLife · doi:10.7554/elife.51421 · Cited by 51 · see citing works
Wang, J., Cohen, A. L., Letian, A., Tadeo, X., Moresco, J. J., Liu, J., Yates, J. R., Qiao, F., & Jia, S. (2016) · Genes & Development · doi:10.1101/gad.266718.115 · Cited by 51 · see citing works
Heterochromatin definition and function
Bell, O., Burton, A., Dean, C., Gasser, S. M., & Torres‐Padilla, M. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00599-7 · Cited by 49 · see citing works
Changes to histone modifications following prenatal alcohol exposure: An emerging picture
Chater‐Diehl, E., Laufer, B. I., & Singh, S. M. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.01.005 · Cited by 48 · see citing works
Cotobal, C., Rodríguez‐López, M., Duncan, C. D. S., Hasan, A., Yamashita, A., Yamamoto, M. P., Bähler, J., & Mata, J. (2015) · Epigenetics & Chromatin · doi:10.1186/s13072-015-0018-4 · Cited by 48 · see citing works
Persistent epigenetic reprogramming of sweet taste by diet
Vaziri, A., Khabiri, M., Genaw, B. T., May, C. E., Freddolino, P. L., & Dus, M. (2020) · Science Advances · doi:10.1126/sciadv.abc8492 · Cited by 47 · see citing works
A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading
Shan, C., Wang, J., Xu, K., Chen, H., Yue, J., Andrews, S. J., Moresco, J. J., Yates, J. R., Nagy, P. L., Tong, L., et al. (2016) · eLife · doi:10.7554/elife.17903 · Cited by 45 · see citing works
Yeast epigenetics: the inheritance of histone modification states
O’Kane, C. J., & Hyland, E. M. (2019) · Bioscience Reports · doi:10.1042/bsr20182006 · Cited by 46 · see citing works
Questa, J. I., Antoniou-Kourounioti, R. L., Rosa, S., Li, P., Duncan, S. H., Whittaker, C., Howard, M., & Dean, C. (2020) · Genes & Development · doi:10.1101/gad.333245.119 · Cited by 45 · see citing works
Shipkovenska, G. G., Durango, A., Kalocsay, M., Gygi, S. P., & Moazed, D. (2020) · eLife · doi:10.7554/elife.54341 · Cited by 44 · see citing works
The Transmission of Intergenerational Epigenetic Information by Sperm microRNAs
Lee, G. S., & Conine, C. C. (2022) · Epigenomes · doi:10.3390/epigenomes6020012 · Cited by 43 · see citing works
Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma
Dupéré-Richer, D., & Licht, J. D. (2017) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000358 · Cited by 43 · see citing works
Padeken, J., Methot, S. P., Zeller, P. J., Delaney, C. E., Kalck, V., & Gasser, S. M. (2020) · Genes & Development · doi:10.1101/gad.344234.120 · Cited by 43 · see citing works
SUV39 SET domains mediate crosstalk of heterochromatic histone marks
Stirpe, A., Guidotti, N., Northall, S. J., Kilic, S., Hainard, A., Vadas, O., Fierz, B., & Schalch, T. (2021) · eLife · doi:10.7554/elife.62682 · Cited by 41 · see citing works
The Arabidopsis epigenetic regulator ICU11 as an accessory protein of Polycomb Repressive Complex 2
Bloomer, R. H., Hutchison, C. E., Bäurle, I., Walker, J., Fang, X., Perera, P., Velanis, C. N., Gümüs, S., Spanos, C., Rappsilber, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920621117 · Cited by 42 · see citing works
Mrc1 regulates parental histone segregation and heterochromatin inheritance
Toda, T., Fang, Y., Shan, C., Hua, X., Kim, J.-K., Tang, L. C., Jovanović, M., Tong, L., Qiao, F., Zhang, Z., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.07.002 · Cited by 41 · see citing works
The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin
Maison, C., Bailly, D., Quivy, J., & Almouzni, G. (2016) · Nature Communications · doi:10.1038/ncomms12224 · Cited by 40 · see citing works
RNA-mediated regulation of heterochromatin
Johnson, W. L., & Straight, A. F. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.05.004 · Cited by 41 · see citing works
Molecular regulatory mechanisms underlying the adaptability of polyploid plants
Scarrow, M., Wang, Y., & Sun, G. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12661 · Cited by 42 · see citing works
Yelagandula, R., Stecher, K., Novatchkova, M., Michetti, L., Michlits, G., Wang, J., Hofbauer, P., Vainorius, G., Pribitzer, C., Isbel, L., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-022-01051-2 · Cited by 38 · see citing works
The Structural Determinants behind the Epigenetic Role of Histone Variants
Cheema, M. S., & Ausió, J. (2015) · Genes · doi:10.3390/genes6030685 · Cited by 38 · see citing works
Position‐effect variegation revisited: HUSHing up heterochromatin in human cells
Timms, R. T., Tchasovnikarova, I. A., & Lehner, P. J. (2016) · BioEssays · doi:10.1002/bies.201500184 · Cited by 38 · see citing works
Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3
Martins, N. M. C., Bergmann, J. H., Shono, N., Kimurâ, H., Larionov, V., Masumoto, H., & Earnshaw, W. C. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-08-0605 · Cited by 38 · see citing works
Broche, J., Kungulovski, G., Bashtrykov, P., Rathert, P., & Jeltsch, A. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1169 · Cited by 38 · see citing works
MicroRNA regulates the toxicological mechanism of four mycotoxins in vivo and in vitro
Chen, J., Yang, S., Li, P., Wu, A., Nepovimová, E., Long, M., Wu, W., & Kuča, K. (2022) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00653-4 · Cited by 37 · see citing works
The epigenetic origin of life history transitions in plants and algae
Vigneau, J., & Borg, M. (2021) · Plant Reproduction · doi:10.1007/s00497-021-00422-3 · Cited by 37 · see citing works
Hore, T. A. (2017) · Epigenomics · doi:10.2217/epi-2017-0021 · Cited by 36 · see citing works
Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatinPreprint
Bao, K., Shan, C., Moresco, J. J., Yates, J. R., & Jia, S. (2018) · Genes & Development · doi:10.1101/gad.318030.118 · Cited by 36 · see citing works
- Authors
- Audergon, P. N. C. B., Catania, S., Kagansky, A., Tong, P., Shukla, M., Pidoux, A. L., & Allshire, R. C.
- Affiliations
- Wellcome Centre for Cell Biology (GB)
- Corresponding author
- Allshire, Robin C.
- ORCID
- Venue
- Science
- Published
- 2015-04-03
- Volume
- 348
- Issue
- 6230
- Pages
- 132-135
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4397586
- OpenAlex
- W2105077884
- Cited by
- 254
- References
- 32
- Citations by year
- 2026: 14 · 2025: 10 · 2024: 29 · 2023: 20 · 2022: 21 · 2021: 23 · 2020: 26 · 2019: 22 · 2018: 15 · 2017: 35 · 2016: 26 · 2015: 13
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ERA (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (93852)
- Wellcome Trust Principal Research Fellowship (95021)
- EC-NOE-EpiGeneSys (HEALTH-F4-2010-257082)
- Wellcome Trust Centre for Cell Biology (92076)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- H3K9 methylation, epigenetic inheritance, heterochromatin, Clr4, histone demethylase, histone methyltransferase, transgenerational inheritance, meiosis, mitotic inheritance, Schizosaccharomyces pombe
- MeSH terms
- Heterochromatin, Histones, Lysine, Methylation, Methyltransferases, Mutation, Nuclear Proteins, Histone-Lysine N-Methyltransferase, Protein Processing, Post-Translational, Schizosaccharomyces, Cell Cycle Proteins, Schizosaccharomyces pombe Proteins, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review