The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Dermal adipocytes protect against invasive Staphylococcus aureus skin infection
Open accessAbstract
Skin infection triggers fat responses: Obesity is associated with chronic inflammation, but does fat tissue offer protection during infection? Zhang et al. noticed that the fat layers in the skin of mice thickened after inoculation with the pathogenic bacterium Staphylococcus aureus (see the Perspective by Alcorn and Kolls). Mutant mice incapable of forming new fat cells were more susceptible to infection. The differentiating fat cells secreted a small-molecule peptide called cathelicidin, specifically in response to the infection. By contrast, mature fat cells produce less cathelicidin, and are thus less protective. Science , this issue p. 67 ; see also p. 26
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“During S. aureus subcutaneous infection in mice, dermal fibroblasts undergo reactive adipogenesis and expand as preadipocytes that secrete CAMP (Cathelicidin Antimicrobial Peptide) [97].”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [97]
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“epicutaneous and intradermal infection elicits different immune responses [41, 42]”
From Single-cell transcriptomics unveils skin cell specific antifungal immune responses and IL-1Ra- IL-1R immune evasion strategies of emerging fungal pathogen Candida auris (2024) · cites this paper as [42]
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Citations
Cites
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237
Atopic Dermatitis: Global Epidemiology and Risk Factors
Nutten, S. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000370220 · Cited by 3,124
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Self-citationSkin immune sentinels in health and disease
Nestle, F. O., Meglio, P. D., Qin, J., & Nickoloff, B. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2622 · Cited by 1,529
Green, H., & Kehinde, O. (1975) · Cell · doi:10.1016/0092-8674(75)90087-2 · Cited by 1,381
Distinct fibroblast lineages determine dermal architecture in skin development and repair
Driskell, R. R., Lichtenberger, B. M., Hoste, E., Kretzschmar, K., Simons, B. D., Charalambous, M., Ferron, S. R., Herault, Y., Pavlovic, G., Ferguson-Smith, A. C., et al. (2013) · Nature · doi:10.1038/nature12783 · Cited by 1,291
Innate antimicrobial peptide protects the skin from invasive bacterial infection
Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198
Self-citationAntibacterial peptides: basic facts and emerging concepts
Boman, H. G. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01228.x · Cited by 1,171
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F., & Daley, G. Q. (2009) · Nature · doi:10.1038/nature08099 · Cited by 1,129
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S. E., & Cotsarelis, G. (2007) · Nature · doi:10.1038/nature05766 · Cited by 1,064
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Peña, O. A., & Martin, P. B. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00715-1 · Cited by 1,827
Fibroblasts: Origins, definitions, and functions in health and disease
Plikus, M. V., Wang, X., Sinha, S., Forte, E., Thompson, S. M., Herzog, E. L., Driskell, R. R., Rosenthal, N. A., Biernaskie, J. A., & Horsley, V. (2021) · Cell · doi:10.1016/j.cell.2021.06.024 · Cited by 1,247
Self-citationNakatsuji, T., Chen, T. H., Narala, S., Chun, K. A., Two, A. M., Yun, T., Shafiq, F., Kotol, P. F., Bouslimani, A., Melnik, A. V., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah4680 · Cited by 1,095
Self-citationDiabetic Wound-Healing Science
Burgess, J. L., Wyant, W. A., Abujamra, B. A., Kirsner, R. S., & Jozic, I. (2021) · Medicina · doi:10.3390/medicina57101072 · Cited by 1,024
Metadata
- Authors
- Zhang, L.-J., Guerrero-Juarez, C. F., Hata, T., Bapat, S. P., Ramos, R., Plikus, M. V., & Gallo, R. L.
- Affiliations
- University of California San Diego (US)
- Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA.
- Salk Institute for Biological Studies (US)
- University of California, Irvine (US)
- Corresponding author
- Gallo, Richard L.
- Venue
- Science
- Published
- 2015-01-02
- Volume
- 347
- Issue
- 6217
- Pages
- 67-71
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4318537
- OpenAlex
- W2021691433
- Cited by
- 471
- References
- 38
- Citations by year
- 2026: 30 · 2025: 37 · 2024: 47 · 2023: 43 · 2022: 46 · 2021: 52 · 2020: 36 · 2019: 44 · 2018: 45 · 2017: 36 · 2016: 30 · 2015: 25
- FWCI
- 38.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH (R01 AI083358, R01AI052453, AR052728, DK096828)
- California Institute for Regenerative Medicine (TG2-01152)
- The Atopic Dermatitis Research Network (HHSN272201000020C)
- Edward Mallinckrodt Jr. Foundation Research
- Dermatology Foundation Research
- NIH NIAMS (R01-AR067273)
- NIH MBRS-IMSD (GM055246)
- NSF Graduate Research Fellowship (DGE-1321846)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- Staphylococcus aureus, skin infections, host defense, adipogenesis, preadipocyte proliferation, cathelicidin, antimicrobial peptides, PPARγ, Zfp423, bacterial virulence
- MeSH terms
- Animals, DNA-Binding Proteins, Mice, Mutant Strains, Staphylococcal Skin Infections, Staphylococcus aureus, Transcription Factors, Adipocytes, Dermis, Antimicrobial Cationic Peptides, 3T3-L1 Cells, Adipogenesis, Mice, Cathelicidins, Host-Pathogen Interactions
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