The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Dermal adipocytes protect against invasive Staphylococcus aureus skin infection
Open accessAbstract
Skin infection triggers fat responses: Obesity is associated with chronic inflammation, but does fat tissue offer protection during infection? Zhang et al. noticed that the fat layers in the skin of mice thickened after inoculation with the pathogenic bacterium Staphylococcus aureus (see the Perspective by Alcorn and Kolls). Mutant mice incapable of forming new fat cells were more susceptible to infection. The differentiating fat cells secreted a small-molecule peptide called cathelicidin, specifically in response to the infection. By contrast, mature fat cells produce less cathelicidin, and are thus less protective. Science , this issue p. 67 ; see also p. 26
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“During S. aureus subcutaneous infection in mice, dermal fibroblasts undergo reactive adipogenesis and expand as preadipocytes that secrete CAMP (Cathelicidin Antimicrobial Peptide) [97].”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [97]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“epicutaneous and intradermal infection elicits different immune responses [41, 42]”
From Single-cell transcriptomics unveils skin cell specific antifungal immune responses and IL-1Ra- IL-1R immune evasion strategies of emerging fungal pathogen Candida auris (2024) · cites this paper as [42]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237
Atopic Dermatitis: Global Epidemiology and Risk Factors
Nutten, S. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000370220 · Cited by 3,124
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Self-citationSkin immune sentinels in health and disease
Nestle, F. O., Meglio, P. D., Qin, J., & Nickoloff, B. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2622 · Cited by 1,520
Green, H., & Kehinde, O. (1975) · Cell · doi:10.1016/0092-8674(75)90087-2 · Cited by 1,381
Distinct fibroblast lineages determine dermal architecture in skin development and repair
Driskell, R. R., Lichtenberger, B. M., Hoste, E., Kretzschmar, K., Simons, B. D., Charalambous, M., Ferron, S. R., Herault, Y., Pavlovic, G., Ferguson-Smith, A. C., et al. (2013) · Nature · doi:10.1038/nature12783 · Cited by 1,291
Innate antimicrobial peptide protects the skin from invasive bacterial infection
Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198
Self-citationAntibacterial peptides: basic facts and emerging concepts
Boman, H. G. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01228.x · Cited by 1,171
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F., & Daley, G. Q. (2009) · Nature · doi:10.1038/nature08099 · Cited by 1,129
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S. E., & Cotsarelis, G. (2007) · Nature · doi:10.1038/nature05766 · Cited by 1,064
Epithelial antimicrobial defence of the skin and intestine
Gallo, R. L., & Hooper, L. V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3228 · Cited by 1,020
Self-citationSørensen, O. E., Follin, P., Johnsen, A. H., Calafat, J., Tjabringa, G. S., Hiemstra, P. S., & Borregaard, N. (2001) · Blood · doi:10.1182/blood.v97.12.3951 · Cited by 894
Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
Yamasaki, K., Nardo, A. D., Bardan, A., Murakami, M., Ohtake, T., Coda, A. B., Dorschner, R. A., Bonnart, C., Descargues, P., Hovnanian, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1616 · Cited by 864
Self-citationPPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scalePreprint
Lefterova, M. I., Zhang, Y., Steger, D. J., Schupp, M., Schug, J., Cristancho, A. G., Feng, D., Zhuo, D. X., Stoeckert, C. J., Liu, X. S., et al. (2008) · Genes & Development · doi:10.1101/gad.1709008 · Cited by 826
Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene
Tanaka, T., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7432 · Cited by 804
Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury
Lai, Y., Di Nardo, A., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A. L., Wu, Z.-R., Hooper, L. V., Schmidt, R. R., von Aulock, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2062 · Cited by 781
Self-citationAdipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling
Festa, E., Fretz, J. A., Berry, R., Schmidt, B., Rodeheffer, M. S., Horowitz, M. C., & Horsley, V. (2011) · Cell · doi:10.1016/j.cell.2011.07.019 · Cited by 616
Transcriptional Control of Adipose Lipid Handling by IRF4
Eguchi, J., Wang, X., Yu, S., Kershaw, E. E., Chiu, P. C., Dushay, J. R., Estall, J. L., Klein, U., Maratos–Flier, E., & Rosen, E. D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.005 · Cited by 597
Dorschner, R. A., Pestonjamasp, V. K., Tamakuwala, S., Ohtake, T., Rudisill, J., Nizet, V., Agerberth, B., Gudmundsson, G. H., & Gallo, R. L. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01340.x · Cited by 567
Self-citationTranscriptional control of preadipocyte determination by Zfp423
Gupta, R. K., Arany, Z. P., Seale, P., Mepani, R. J., Li, Y., Conroe, H. M., Roby, Y. A., Kulaga, H. M., Reed, R. R., & Spiegelman, B. M. (2010) · Nature · doi:10.1038/nature08816 · Cited by 555
Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study
Pütsep, K., Carlsson, G., Boman, H. G., & Andersson, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11201-3 · Cited by 499
Adipose tissue stem cells meet preadipocyte commitment: going back to the future
Cawthorn, W. P., Scheller, E. L., & MacDougald, O. A. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r021089 · Cited by 467
Methicillin-resistant Staphylococcus aureus strain USA300: origin and epidemiology
Tenover, F. C., & Goering, R. V. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp241 · Cited by 456
Immunity against Staphylococcus aureus cutaneous infections
Miller, L. S., & Cho, J. S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3010 · Cited by 439
Gupta, R. K., Mepani, R. J., Kleiner, S., Lo, J. C., Khandekar, M. J., Cohen, P., Frontini, A., Bhowmick, D. C., Ye, L., Cinti, S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.010 · Cited by 426
Intradermal adipocytes mediate fibroblast recruitment during skin wound healing
Schmidt, B. A., & Horsley, V. (2013) · Development · doi:10.1242/dev.087593 · Cited by 318
Innate immunity and adipose tissue biology
Schäffler, A., & Schölmerich, J. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.03.001 · Cited by 283
Minireview: Pref-1: Role in Adipogenesis and Mesenchymal Cell Fate
Sul, H. S. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0160 · Cited by 218
A single clone of Staphylococcus aureus causes the majority of cases of toxic shock syndrome.
Musser, J. M., Schlievert, P. M., Chow, A. W., Ewan, P., Kreiswirth, B. N., Rosdahl, V. T., Naidu, A. S., Witte, W., & Selander, R. K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.225 · Cited by 190
Processing of Seminal Plasma hCAP-18 to ALL-38 by Gastricsin
Sørensen, O. E., Gram, L., Johnsen, A. H., Andersson, E., Bangsbøll, S., Tjabringa, G. S., Hiemstra, P. S., Malm, J., Egesten, A., & Borregaard, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301608200 · Cited by 166
Pref-1 Marks Very Early Mesenchymal Precursors Required for Adipose Tissue Development and Expansion
Hudak, C. S. S., Gulyaeva, О. N., Wang, Y., Park, S.-M., Lee, L. P., Kang, C., & Sul, H. S. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.060 · Cited by 125
ADAM 12 Protease Induces Adipogenesis in Transgenic Mice
Kawaguchi, N., Xu, X., Tajima, R., Kronqvist, P., Sundberg, C., Loechel, F., Albrechtsen, R., & Wewer, U. M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61136-4 · Cited by 101
Hyaluronan digestion controls DC migration from the skin
Muto, J., Morioka, Y., Yamasaki, K., Kim, M., Garcia, A., Carlin, A. F., Varki, A., & Gallo, R. L. (2014) · Journal of Clinical Investigation · doi:10.1172/jci67947 · Cited by 84
Self-citationAlcaraz, W. A., Gold, D. A., Raponi, É., Gent, P. M., Concepcion, D., & Hamilton, B. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609184103 · Cited by 79
Zhang, L., Vogel, W., Liu, X., Topark‐Ngarm, A., Arbogast, B. L., Maier, C. S., Filtz, T. M., & Leid, M. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.344176 · Cited by 74
Self-citationSillat, T., Saat, R., Pöllänen, R., Hukkanen, M., Takagi, M., & Konttinen, Y. T. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01442.x · Cited by 68
Cheng, L. E., Zhang, J., & Reed, R. R. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.04.005 · Cited by 60
Zhang, L., Bhattacharya, S., Leid, M. E., Ganguli‐Indra, G., & Indra, A. K. (2012) · Journal of Cell Science · doi:10.1242/jcs.108969 · Cited by 43
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806
Cellular and molecular mechanisms of skin wound healing
Peña, O. A., & Martin, P. B. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00715-1 · Cited by 1,827
Fibroblasts: Origins, definitions, and functions in health and disease
Plikus, M. V., Wang, X., Sinha, S., Forte, E., Thompson, S. M., Herzog, E. L., Driskell, R. R., Rosenthal, N. A., Biernaskie, J. A., & Horsley, V. (2021) · Cell · doi:10.1016/j.cell.2021.06.024 · Cited by 1,247
Self-citationNakatsuji, T., Chen, T. H., Narala, S., Chun, K. A., Two, A. M., Yun, T., Shafiq, F., Kotol, P. F., Bouslimani, A., Melnik, A. V., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah4680 · Cited by 1,095
Self-citationDiabetic Wound-Healing Science
Burgess, J. L., Wyant, W. A., Abujamra, B. A., Kirsner, R. S., & Jozic, I. (2021) · Medicina · doi:10.3390/medicina57101072 · Cited by 1,024
Metadata
- Authors
- Zhang, L.-J., Guerrero-Juarez, C. F., Hata, T., Bapat, S. P., Ramos, R., Plikus, M. V., & Gallo, R. L.
- Affiliations
- University of California San Diego (US)
- Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA.
- Salk Institute for Biological Studies (US)
- University of California, Irvine (US)
- Corresponding author
- Gallo, Richard L.
- Venue
- Science
- Published
- 2015-01-02
- Volume
- 347
- Issue
- 6217
- Pages
- 67-71
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4318537
- OpenAlex
- W2021691433
- Cited by
- 471
- References
- 38
- Citations by year
- 2026: 30 · 2025: 37 · 2024: 47 · 2023: 43 · 2022: 46 · 2021: 52 · 2020: 36 · 2019: 44 · 2018: 45 · 2017: 36 · 2016: 30 · 2015: 25
- FWCI
- 38.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH (R01 AI083358, R01AI052453, AR052728, DK096828)
- California Institute for Regenerative Medicine (TG2-01152)
- The Atopic Dermatitis Research Network (HHSN272201000020C)
- Edward Mallinckrodt Jr. Foundation Research
- Dermatology Foundation Research
- NIH NIAMS (R01-AR067273)
- NIH MBRS-IMSD (GM055246)
- NSF Graduate Research Fellowship (DGE-1321846)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- Staphylococcus aureus, skin infections, host defense, adipogenesis, preadipocyte proliferation, cathelicidin, antimicrobial peptides, PPARγ, Zfp423, bacterial virulence
- MeSH terms
- Animals, DNA-Binding Proteins, Mice, Mutant Strains, Staphylococcal Skin Infections, Staphylococcus aureus, Transcription Factors, Adipocytes, Dermis, Antimicrobial Cationic Peptides, 3T3-L1 Cells, Adipogenesis, Mice, Cathelicidins, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
