The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Expression of a Ryanodine Receptor-Ca 2+ Channel that is Regulated by TGF-β
Abstract
Ryanodine receptors (RyRs) are intracellular channels that release calcium ions from the sarcoplasmic reticulum (SR) in response to either plasma membrane depolarization (in skeletal muscle) or increases in the concentration of intracellular free Ca 2+ (in the heart). A gene (β4) encoding a ryanodine receptor (similar to, but distinct from, the muscle RyRs) was identified. The β4 gene was expressed in all tissues investigated, with the exception of heart. Treatment of mink lung epithelial cells (Mv1Lu) with transforming growth factor beta (TGF-β) induced expression of the β4 gene together with the release of Ca 2+ in response to ryanodine (but not in response to caffeine, the other drug active on muscle RyRs). This ryanodine receptor may be important in the regulation of intracellular Ca 2+ homeostasis.
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Cites
Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor
Takeshima, H., Nishimura, S., Matsumoto, T., Ishida, H., Kangawa, K., Minamino, N., Matsuo, H., Ueda, M., Hanaoka, M., Hirose, T., et al. (1989) · Nature · doi:10.1038/339439a0 · Cited by 1,146
Cited by
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
INTRACELLULAR CALCIUM RELEASE AND CARDIAC DISEASE
Wehrens, X. H. T., Lehnart, S. E., & Marks, A. R. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.114521 · Cited by 355
Galione, A., McDougall, A., Busa, W. B., Willmott, N., Gillot, I., & Whitaker, M. (1993) · Science · doi:10.1126/science.8392748 · Cited by 310
Wong, P. W., Brackney, W. R., & Pessah, I. N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15145 · Cited by 124
Metadata
- Authors
- Giannini, G., Clementi, E., Ceci, R., Marziali, G., & Sorrentino, V.
- Venue
- Science
- Published
- 1992-07-03
- Volume
- 257
- Issue
- 5066
- Pages
- 91-94
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037744654
- Cited by
- 246
- References
- 1
- FWCI
- 10.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Giannini, G., Clementi, E., Ceci, R., Marziali, G., & Sorrentino, V. (1992). Expression of a Ryanodine Receptor-Ca 2+ Channel that is Regulated by TGF-β. Science. https://doi.org/10.1126/science.1320290
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
