Roles of two preoptic cell groups in tonic and febrile control of rat tail sympathetic fibers
Abstract
In response to cold and in fever, heat dissipation from the skin is reduced by sympathetic vasoconstriction. The preoptic region has been implicated in regulating basal, thermal, and febrile vasoconstriction of cutaneous vessels such as the rat's tail, but the neurons responsible for these functions have not been well localized. We recorded activity from single sympathetic nerve fibers supplying tail vessels in urethane-anesthetized rats, while microinjections of GABA (300 mM, 15-30 nl) were used to inhibit neurons in different parts of the preoptic region. Tail fiber activity increased promptly after GABA injections in two distinct regions: a rostromedial preoptic region (RMPO) centered around the organum vasculosum of the lamina terminalis, and a second region centered approximately 1 mm caudolaterally (CLPO). Responses to GABA within each region were similar. The febrile mediator, PGE(2) (0.2 or 1 ng in 15 nl) was then microinjected into GABA-sensitive preoptic sites. Injections of PGE(2) into the RMPO induced a rapid increase in tail fiber activity followed by a rise in core temperature; injections into the rostromedial part of CLPO gave delayed tail fiber responses; injections into the central and caudal parts of CLPO were without effect. These results indicate that neurons in two distinct preoptic regions provide tonic inhibitory drive to the tail vasoconstrictor supply, but febrile vasoconstriction is mediated by PGE(2) selectively inhibiting neurons in the rostromedial region.
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Warm-sensitive neurons located in the medial preoptic area project to the rostral raphe pallidus, either directly or through the dorsomedial hypothalamus.
“Warm-sensitive neurons located in the medial preoptic area project to the rostral raphe pallidus in the medulla, either directly or through the dorsomedial hypothalamus (Morrison and Nakamura, 2011; Tanaka et al., 2009; Yoshida et al., 2009).”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Tanaka et al., 2009
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Bayliss, D. A., & Shi, Y. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734190697.793552286
- Authors
- Tanaka, M., McKinley, M. J., & McAllen, R. M.
- Affiliations
- The University of Melbourne (AU)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2009-04
- Volume
- 296
- Issue
- 4
- Pages
- R1248-R1257
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2033887998
- Cited by
- 60
- References
- 48
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2018: 10 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 6
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- preoptic area, organum vasculosum of the lamina terminalis, cutaneous vasoconstriction, prostaglandin E2, fever, thermoregulation, core body temperature
- MeSH terms
- Adrenergic Fibers, Animals, Blood Vessels, Body Temperature Regulation, Cold Temperature, Fever, gamma-Aminobutyric Acid, Male, Microinjections, Neural Inhibition, Neural Pathways, Preoptic Area, Skin, Sympathetic Nervous System, Tail, Time Factors, Vasoconstriction, Dinoprostone, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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