The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
The Human Y Chromosome: Overlapping DNA Clones Spanning the Euchromatic Region
Abstract
The human Y chromosome was physically mapped by assembling 196 recombinant DNA clones, each containing a segment of the chromosome, into a single overlapping array. This array included more than 98 percent of the euchromatic portion of the Y chromosome. First, a library of yeast artificial chromosome (YAC) clones was prepared from the genomic DNA of a human XYYYY male. The library was screened to identify clones containing 160 sequence-tagged sites and the map was then constructed from this information. In all, 207 Y-chromosomal DNA loci were assigned to 127 ordered intervals on the basis of their presence or absence in the YAC's, yielding ordered landmarks at an average spacing of 220 kilobases across the euchromatic region. The map reveals that Y-chromosomal genes are scattered among a patchwork of X-homologous, Y-specific repetitive, and single-copy DNA sequences. This map of overlapping clones and ordered, densely spaced markers should accelerate studies of the chromosome.
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Cites
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Self-citationCloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors
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The sex-determining region of the human Y chromosome encodes a finger protein
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Self-citation
Cited by
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes
Skaletsky, H., Kuroda-Kawaguchi, T., Minx, P. J., Cordum, H. S., Hillier, L., Brown, L. G., Repping, S., Pyntikova, T., Ali, J., Bieri, T., et al. (2003) · Nature · doi:10.1038/nature01722 · Cited by 2,120
Self-citationAn STS-Based Map of the Human Genome
Hudson, T. J., Stein, L. D., Gerety, S. S., Ma, J., Castle, A. B., Silva, J., Slonim, D. K., Baptista, R., Kruglyak, L., Xu, S.-H., et al. (1995) · Science · doi:10.1126/science.270.5244.1945 · Cited by 773
Self-citationApparent intrachromosomal exchange on the human Y chromosome explained by population history
Kittler, R., Erler, A., Brauer, S., Stoneking, M., & Kayser, M. (2003) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200960 · Cited by 51
Metadata
- Authors
- Foote, S., Vollrath, D., Hilton, A., & Page, D. C.
- Venue
- Science
- Published
- 1992-10-02
- Volume
- 258
- Issue
- 5079
- Pages
- 60-66
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965412944
- Cited by
- 386
- References
- 43
- FWCI
- 26.62
- Type
- journal article
- Language
- en
- Open access
- closed
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