The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Control by Asparagine Residues of Calcium Permeability and Magnesium Blockade in the NMDA Receptor
Abstract
The N -methyl-D-aspartate (NMDA) receptor forms a cation-selective channel with a high calcium permeability and sensitivity to channel block by extracellular magnesium. These properties, which are believed to be important for the induction of long-term changes in synaptic strength, are imparted by asparagine residues in a putative channel-forming segment of the protein, transmembrane 2 (TM2). In the NR1 subunit, replacement of this asparagine by a glutamine residue decreases calcium permeability of the channel and slightly reduces magnesium block. The same substitution in NR2 subunits strongly reduces magnesium block and increases the magnesium permeability but barely affects calcium permeability. These asparagines are in a position homologous to the site in the TM2 region (Q/R site) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors that is occupied by either glutamine (Q) or arginine (R) and that controls divalent cation permeability of the AMPA receptor channel. Hence AMPA and NMDA receptor channels contain common structural motifs in their TM2 segments that are responsible for some of their ion selectivity and conductance properties.
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Cites
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Cited by
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,658
Molecular diversity of glutamate receptors and implications for brain function
Nakanishi, S. (1992) · Science · doi:10.1126/science.1329206 · Cited by 2,543
Glutamate receptors in the mammalian central nervous system
Ozawa, S., Kamiya, H., & Tsuzuki, K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00085-3 · Cited by 1,122
Metadata
- Authors
- Burnashev, N., Schoepfer, R., Monyer, H., Ruppersberg, J. P., Günther, W., Seeburg, P. H., & Sakmann, B.
- Venue
- Science
- Published
- 1992-09-04
- Volume
- 257
- Issue
- 5075
- Pages
- 1415-1419
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2074340804
- Cited by
- 451
- References
- 35
- FWCI
- 14.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Burnashev, N., Schoepfer, R., Monyer, H., Ruppersberg, J. P., Günther, W., Seeburg, P. H., & Sakmann, B. (1992). Control by Asparagine Residues of Calcium Permeability and Magnesium Blockade in the NMDA Receptor. Science. https://doi.org/10.1126/science.1382314
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
