The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes
Abstract
Despite decades of intensive investigation, the basic pathophysiological mechanisms responsible for the metabolic derangements associated with diabetes mellitus have remained elusive. Explored here is the possibility that traditional concepts in this area might have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance and hyperglycemia might be more readily understood if viewed in the context of underlying abnormalities of lipid metabolism.
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In the citing paper
“Although it is clear that insulin resistance plays a major role in the pathogenesis of T2DM”
From Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men (2006) · cites this paper as [12]
In the citing paper
“and that insulin resistance is strongly associated with increases in hepatic (HTG) and ∕ or intramyocellular lipid content”
From Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men (2006) · cites this paper as [12]
Citations
Cites
Pathogenesis of NIDDM. A balanced overview.
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McGarry, J. D., & Foster, D. W. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.002143 · Cited by 1,460
Self-citationStorlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., & Kraegen, E. W. (1991) · Diabetes · doi:10.2337/diab.40.2.280 · Cited by 967
Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM
Reaven, G. M., Hollenbeck, C., Jeng, C.-Y., Wu, M. S., & Chen, Y.-D. I. (1988) · Diabetes · doi:10.2337/diab.37.8.1020 · Cited by 753
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
Vionnet, N., Stoffel, M., Takeda, J., Yasuda, K., Bell, G. I., Zouali, H., Lesage, S., Velho, G., Iris, F., Passa, P., et al. (1992) · Nature · doi:10.1038/356721a0 · Cited by 605
Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase
McGarry, J., Woeltje, K. F., Kuwajima, M., & Foster, D. W. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050305 · Cited by 359
Self-citationVaag, A., Henriksen, J. E., & Beck-Nielsen, H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115656 · Cited by 299
Diabetic Hyperglycemia: Link to Impaired Glucose Transport in Pancreatic β Cells
Unger, R. H. (1991) · Science · doi:10.1126/science.2006409 · Cited by 263
Mechanisms decreasing glucose oxidation in diabetes and starvation: Role of lipid fuels and hormones
Randle, P. J., Kerbey, A. L., & Espinal, J. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040702 · Cited by 241
Bailey, C. J., & Flatt, P. R. (1990) · Medical Entomology and Zoology · Cited by 214
Research works printed but not linked: 3
- MARBAN, S.L., DIABETES 41: 145A (1992).
- Unger, R. H., Handbook of Experimental Pharmacology: Glucagon II 2: 431 (1983).
- Wolf, H. P. O. , New Antidiabetic Drugs: 217 (1990).
Cited by
Sorted by citations
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714
Metadata
- Authors
- McGarry, J. D.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- McGarry, J. Denis
- ORCID
- McGarry, J. Denis
- Venue
- Science
- Published
- 1992-10-30
- Volume
- 258
- Issue
- 5083
- Pages
- 766-770
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036344921
- Cited by
- 657
- References
- 24
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 16 · 2019: 10 · 2018: 12 · 2017: 18 · 2016: 16 · 2015: 20 · 2014: 16 · 2013: 21 · 2012: 25
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk011313-25)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 18573, DK11313)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- diabetes mellitus, insulin resistance, hyperglycemia, lipid metabolism, metabolic disorders, diabetes pathophysiology
- MeSH terms
- Acetoacetates, Adipose Tissue, Blood Glucose, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Glucose Tolerance Test, Humans, Hydroxybutyrates, Insulin, Insulin Resistance, Islets of Langerhans, Ketone Bodies, Lipoproteins, VLDL, Liver, Triglycerides, 3-Hydroxybutyric Acid, Lipid Metabolism
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