Cited by 657Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetesDiabetes Management and Research

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What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

McGarry, J. Denis·1992·Science

DOI 10.1126/science.1439783

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Abstract

Despite decades of intensive investigation, the basic pathophysiological mechanisms responsible for the metabolic derangements associated with diabetes mellitus have remained elusive. Explored here is the possibility that traditional concepts in this area might have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance and hyperglycemia might be more readily understood if viewed in the context of underlying abnormalities of lipid metabolism.

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Authors: McGarry, J. D.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: McGarry, J. Denis
ORCID: McGarry, J. Denis
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1992-10-30
Volume: 258
Issue: 5083
Pages: 766-770
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1439783
OpenAlex: W2036344921
Cited by: 657
References: 24
Citations by year: 2026: 4 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 16 · 2019: 10 · 2018: 12 · 2017: 18 · 2016: 16 · 2015: 20 · 2014: 16 · 2013: 21 · 2012: 25
FWCI: 6.77
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk011313-25)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 18573, DK11313)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: diabetes mellitus, insulin resistance, hyperglycemia, lipid metabolism, metabolic disorders, diabetes pathophysiology
MeSH terms: Acetoacetates, Adipose Tissue, Blood Glucose, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Glucose Tolerance Test, Humans, Hydroxybutyrates, Insulin, Insulin Resistance, Islets of Langerhans, Ketone Bodies, Lipoproteins, VLDL, Liver, Triglycerides, 3-Hydroxybutyric Acid, Lipid Metabolism

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What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

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