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Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity
Abstract
The cell type responsible for inhibition by antigen of migration in vitro of peritoneal exudate cells obtained from tuberculin-hypersensitive guinea pigs was studied. Exudate populations were separated into component cell types, the lymphocyte and the macrophage. Peritoneal lymphocytes from sensitive donors were the immunologically active cells in this system, the macrophages, being merely indicator cells which migrate. Sensitized peritoneal lymphocyte populations, upon interaction with specific antigen in vitro, elaborated into the medium a soluble material capable of inhibiting migration of normal exudate cells.
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Citations
Cited by
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MIF Signal Transduction Initiated by Binding to CD74
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“Originally identified over 50 years ago as a secreted lymphocyte product associated with macrophage-dependent delayed-type hypersensitivity (2, 3), MIF has become one of the most enigmatic regulators of innate and adaptive immune responses.”
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Zang, X., Taylor, P., Wang, J. M., Meyer, D. J., Scott, A. L., Walkinshaw, M. D., & Maizels, R. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204655200 · Cited by 108
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Park, S. K., Cho, M. K., Park, H.-K., Lee, K. H., Lee, S. J., Choi, S. H., Ock, M. S., Jeong, H. J., Lee, M. H., & Yu, H. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803533 · Cited by 82
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Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis
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The role of MIF in chronic lung diseases: looking beyond inflammation
Florez-Sampedro, L., Soto-Gamez, A., Poelarends, G. J., & Melgert, B. N. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00521.2019 · Cited by 47
Zhang, Y., Lu, S., Fan, S., Xu, L., Jiang, X., Wang, K., & Cai, B. (2021) · Aging · doi:10.18632/aging.202505 · Cited by 33
Nakamaru, Y., Takagi, D., Oridate, N., Furuta, Y., Nishihira, J., & Fukuda, S. (2004) · Annals of Otology, Rhinology & Laryngology · doi:10.1177/000348940411300306 · Cited by 13
Metadata
- Authors
- Bloom, B. R., & Bennett, B.
- Venue
- Science
- Published
- 1966-07
- Volume
- 153
- Issue
- 3731
- Pages
- 80-82
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001634895
- Cited by
- 1,603
- References
- 0
- FWCI
- 20.78
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
