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The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

Duensing, Stefan, Lee, Lily Y., Duensing, Anette, Basile, John, Piboonniyom, Siribang-on, Gonzalez, Sonia, Crum, Christopher P., Münger, Karl·2000·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.170093297
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Abstract

Loss of genomic integrity is a defining feature of many human malignancies, including human papillomavirus (HPV)-associated preinvasive and invasive genital squamous lesions. Here we show that aberrant mitotic spindle pole formation caused by abnormal centrosome numbers represents an important mechanism in accounting for numeric chromosomal alterations in HPV-associated carcinogenesis. Similar to what we found in histopathological specimens, HPV-16 E6 and E7 oncoproteins cooperate to induce abnormal centrosome numbers, aberrant mitotic spindle pole formation, and genomic instability. The low-risk HPV-6 E6 and E7 proteins did not induce such abnormalities. Whereas the HPV-16 E6 oncoprotein has no immediate effects on centrosome numbers, HPV-16 E7 rapidly induces abnormal centrosome duplication. Thus our results suggest a model whereby HPV-16 E7 induces centrosome-related mitotic disturbances that are potentiated by HPV-16 E6.

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Research works printed but not linked: 36

  1. 10.1126/science.1659743 · DOI
  2. 10.1073/pnas.94.8.3854 · DOI
  3. 10.1073/pnas.93.1.479 · DOI
  4. 10.1099/0022-1317-72-7-1569 · DOI
  5. 10.1101/gad.8.6.666 · DOI
  6. 10.1101/gad.8.18.2227 · DOI
  7. T D Kessis, D C Conolly, L Hedrick, K R Cho Oncogene 13, 427–431 (1996).
  8. 10.1016/0092-8674(90)90409-8 · DOI · Paper page
  9. 10.1128/JVI.72.2.1131-1137.1998 · DOI
  10. S N Boyer, D E Wazer, V Band Cancer Res 56, 4620–4624 (1996).
  11. 10.1126/science.283.5403.851 · DOI
  12. 10.1016/S0960-9822(99)80191-2 · DOI
  13. 10.1073/pnas.96.6.2817 · DOI
  14. G A Pihan, A Purohit, J Wallace, H Knecht, B Woda, P Quesenberry, S J Doxsey Cancer Res 58, 3974–3985 (1998).
  15. 10.1101/gad.11.16.2101 · DOI · Paper page
  16. 10.1016/S0076-6879(97)83011-X · DOI
  17. 10.1128/jvi.65.1.473-478.1991 · DOI · Paper page
  18. 10.1093/nar/23.4.628 · DOI
  19. 10.1126/science.2144057 · DOI
  20. 10.1128/mcb.7.8.2745-2752.1987 · DOI
  21. 10.1073/pnas.96.17.9637 · DOI
  22. 10.1126/science.8266103 · DOI
  23. 10.1128/MCB.16.7.3698 · DOI
  24. 10.1016/0092-8674(94)90504-5 · DOI
  25. 10.1016/0092-8674(91)90390-K · DOI
  26. 10.1128/jvi.66.4.2418-2427.1992 · DOI · Paper page
  27. 10.1006/viro.1997.8851 · DOI · Paper page
  28. 10.1038/10054 · DOI · Paper page
  29. 10.1073/pnas.95.6.2950 · DOI
  30. 10.1038/386623a0 · DOI
  31. 10.1038/sj.onc.1201495 · DOI
  32. 10.1126/science.271.5256.1744 · DOI
  33. 10.1128/JVI.72.2.975-985.1998 · DOI
  34. 10.1073/pnas.89.10.4549 · DOI
  35. 10.1038/2496 · DOI
  36. 10.1016/S0962-8924(99)01661-X · DOI

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Metadata

Authors
Duensing, S., Lee, L. Y., Duensing, A., Basile, J., Piboonniyom, S.-O., Gonzalez, S., Crum, C. P., & Münger, K.
Affiliations
Department of Pathology and Harvard Center for Cancer Biology, Department of Pathology, Solid Tumor Cytogenetics, Brigham and Women's Hospital, and Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2000-08-15
Volume
97
Issue
18
Pages
10002-10007
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.170093297
Cited by
397
References
2
Language
en

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CoChat. (2026). Citation check: The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. https://app.cochat.ai/papers/10.1073/pnas.170093297
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Duensing, S., Lee, L. Y., Duensing, A., Basile, J., Piboonniyom, S.-O., Gonzalez, S., Crum, C. P., & Münger, K. (2000). The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.170093297