The DOI matches its Crossref record.
LFA-3, CD44, and CD45: Physiologic Triggers of Human Monocyte TNF and IL-1 Release
Abstract
The monocyte-derived cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), are central regulators of the immune response, but the physiologic stimuli for their release remain largely undefined. Engagement of three monocyte glycoproteins, LFA-3, CD44, and CD45, by specific monoclonal antibodies immobilized on plastic induced TNF-α and IL-1β release. In addition, TNF-α was released when monocyte LFA-3 bound immobilized, purified CD2, which is its physiologic receptor. Thus, a receptor-ligand interaction that mediates cell-cell adhesion can transmit the necessary signals for the release of monokines.
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Cited by
de la Motte, C. A., Hascall, V. C., Calabro, A., Yen-Lieberman, B., & Strong, S. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30747 · Cited by 189
Cytokine and growth factor production by monocytes/macrophages on protein preadsorbed polymers
Bonfield, T. L., Colton, E., Marchant, R. E., & Anderson, J. M. (1992) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820260702 · Cited by 119
The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers
Nugent, A. P., Roche, H. M., Noone, E. J., Long, A., Kelleher, D. K., & Gibney, M. J. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602132 · Cited by 71
Hayes, A. L., Smith, C., Foxwell, B. M. J., & Brennan, F. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33455 · Cited by 44
Metadata
- Authors
- Webb, D. S. A., Shimizu, Y., Van Seventer, G. A., Shaw, S., & Gerrard, T. L.
- Venue
- Science
- Published
- 1990-09-14
- Volume
- 249
- Issue
- 4974
- Pages
- 1295-1297
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076389722
- Cited by
- 287
- References
- 0
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- closed
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