The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Murine Leukemia Virus: High-Frequency Activation in vitro by 5-Iododeoxyuridine and 5-Bromodeoxyuridine
Abstract
Cells of embryos of the high leukemic mouse strain AKR can be grown in culture as virus-negative cell lines. However, these lines and clonal sublines uniformly have the capacity to initiate synthesis of murine leukemia virus. Exposure of the cells to 5-iododeoxyuridine or 5-bromodeoxyuridine induced synthesis of virus in as high as 0.1 to 0.5 percent of the cells; many of the cells were producing virus as soon as 3 days after initiation of treatment. Induction of virus by these drugs is several orders of magnitude greater than that obtained with any other treatment tested. These studies indicate that the full genome of murine leukemia virus is present in an unexpressed form in all AKR cells and provide a potentially powerful technique for activating leukemia virus genomes in other cell systems.
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Citations
Cites
Plaque assay techniques for murine leukemia viruses
Rowe, W. P., Pugh, W. E., & Hartley, J. W. (1970) · Virology · doi:10.1016/0042-6822(70)90362-4 · Cited by 1,243
Self-citationOn the natural history of the murine leukemias: presidential address.
Kaplan, H. S. (1967) · PubMed · Cited by 327
MIXED CULTURE CYTOPATHOGENICITY: A NEW TEST FOR GROWTH OF MURINE LEUKEMIA VIRUSES IN TISSUE CULTURE
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Self-citationInduction of avian tumor viruses in normal cells by physical and chemical carcinogens
Weiss, R. A., Friis, R. R., Katz, E., & Vogt, P. K. (1971) · Virology · doi:10.1016/0042-6822(71)90091-2 · Cited by 245
Isolation of Naturally Occurring Viruses of the Murine Leukemia Virus Group in Tissue Culture
Hartley, J. W., Rowe, W. P., Capps, W. I., & Huebner, R. J. (1969) · Journal of Virology · doi:10.1128/jvi.3.2.126-132.1969 · Cited by 214
Self-citationRowe, W. P., Hartley, J. W., Lander, M. R., Pugh, W. E., & Teich, N. M. (1971) · Virology · doi:10.1016/0042-6822(71)90087-0 · Cited by 178
Self-citationEvidence for a DNA Replicative Genome for RNA-Containing Tumor Viruses
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Rowe, W. P. (1971) · Virology · doi:10.1016/0042-6822(71)90038-9 · Cited by 13
Self-citation
Cited by
Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus
Like, A. A., & Rossini, A. A. (1976) · Science · doi:10.1126/science.180605 · Cited by 979
Varmus, H. (1988) · Science · doi:10.1126/science.3287617 · Cited by 523
Lieber, M., Mazzetta, J., Nelson‐Rees, W., Kaplan, M., & Todaro, G. (1975) · International Journal of Cancer · doi:10.1002/ijc.2910150505 · Cited by 508
Historical review of the causes of cancer
Blackadar, C. B. (2016) · World Journal of Clinical Oncology · doi:10.5306/wjco.v7.i1.54 · Cited by 389
Induction of HTLV-III/LAV from a Nonvirus-Producing T-Cell Line: Implications for Latency
Folks, T., Powell, D. M., Lightfoote, M. M., Benn, S., Martin, M. A., & Fauci, A. S. (1986) · Science · doi:10.1126/science.3003906 · Cited by 260
Metadata
- Authors
- Lowy, D. R., Rowe, W. P., Teich, N., & Hartley, J. W.
- Venue
- Science
- Published
- 1971-10-08
- Volume
- 174
- Issue
- 4005
- Pages
- 155-156
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985893537
- Cited by
- 585
- References
- 8
- FWCI
- 35.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lowy, D. R., Rowe, W. P., Teich, N., & Hartley, J. W. (1971). Murine Leukemia Virus: High-Frequency Activation in vitro by 5-Iododeoxyuridine and 5-Bromodeoxyuridine. Science. https://doi.org/10.1126/science.174.4005.155
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
