The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Abstract
The prefrontal cortex is involved in the cognitive process of working memory. Local injections of SCH23390 and SCH39166, selective antagonists of the D1 dopamine receptor, into the prefrontal cortex of rhesus monkeys induced errors and increased latency in performance on an oculomotor task that required memory-guided saccades. The deficit was dose-dependent and sensitive to the duration of the delay period. These D1 antagonists had no effect on performance in a control task requiring visually guided saccades, indicating that sensory and motor functions were unaltered. Thus, D1 dopamine receptors play a selective role in the mnemonic, predictive functions of the primate prefrontal cortex.
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“evidence from non‐human primates (Sawaguchi & Goldman‐Rakic, 1991, 1994; Williams & Goldmanrakic, 1995) and in healthy humans (Fischer et al., 2010) showed that dopamine depletion or antagonism impairs visuospatial WM.”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Sawaguchi & Goldman‐Rakic, 1991
In the citing paper
“Both blockade and excessive stimulation of D1 receptors impair spatial working memory65–67.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [66]
In the citing paper
“Cognitive studies in animals have shown that either blockade of D1/5 receptors or excessive stimulation of D1/5 receptors in the PFC impairs spatial working memory (106–108).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [107]
Citations
Cites
Multiple receptors for dopamine
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Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685
Self-citationCognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500
Self-citationKöhler, C., Hall, H., Ögren, S. O., & Gawell, L. (1985) · Biochemical Pharmacology · doi:10.1016/0006-2952(85)90778-6 · Cited by 505
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Injection of solutions into cerebral tissue: Relation between volume and diffusion
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Self-citationDopamine receptors in human brain: Autoradiographic distribution of D2 sites
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Research works printed but not linked: 4
- BERGER, B, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 15: 428 (1989).
- FUNAHASHI, S, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 12: 554 (1986).
- Goldman-Rakic, P.S., Handbook of Physiology, Section 1: The Nervous Systemn 5: 373 (1987).
- MEMO, M, JOURNAL OF NEURAL TRANSMISSION 22: 19 (1986).
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Metadata
- Authors
- Sawaguchi, T., & Goldman-Rakic, P. S.
- Affiliations
- Yale University (US)
- Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.
- Venue
- Science
- Published
- 1991-02-22
- Volume
- 251
- Issue
- 4996
- Pages
- 947-950
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058396154
- Cited by
- 1,364
- References
- 24
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 24 · 2023: 22 · 2022: 31 · 2021: 30 · 2020: 28 · 2019: 31 · 2018: 33 · 2017: 27 · 2016: 40 · 2015: 54 · 2014: 53 · 2013: 34 · 2012: 41
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 44866, MH38546, P50MH044866)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine D1 receptor, prefrontal cortex, working memory, memory-guided saccades, oculomotor tasks, SCH 23390, delay period, rhesus monkeys, memory function
- MeSH terms
- Animals, Benzazepines, Cerebral Cortex, Macaca mulatta, Memory, Receptors, Dopamine, Salicylamides, Visual Perception, Receptors, Dopamine D1, Dopamine Antagonists, Raclopride
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