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D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory

Sawaguchi, Toshiyuki, Goldman-Rakic, Patricia S.·1991·Science

DOI 10.1126/science.1825731

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Abstract

The prefrontal cortex is involved in the cognitive process of working memory. Local injections of SCH23390 and SCH39166, selective antagonists of the D1 dopamine receptor, into the prefrontal cortex of rhesus monkeys induced errors and increased latency in performance on an oculomotor task that required memory-guided saccades. The deficit was dose-dependent and sensitive to the duration of the delay period. These D1 antagonists had no effect on performance in a control task requiring visually guided saccades, indicating that sensory and motor functions were unaltered. Thus, D1 dopamine receptors play a selective role in the mnemonic, predictive functions of the primate prefrontal cortex.

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Authors: Sawaguchi, T., & Goldman-Rakic, P. S.
Affiliations: Yale University (US)
Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1991-02-22
Volume: 251
Issue: 4996
Pages: 947-950
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1825731
OpenAlex: W2058396154
Cited by: 1,364
References: 24
Citations by year: 2026: 9 · 2025: 21 · 2024: 24 · 2023: 22 · 2022: 31 · 2021: 30 · 2020: 28 · 2019: 31 · 2018: 33 · 2017: 27 · 2016: 40 · 2015: 54 · 2014: 53 · 2013: 34 · 2012: 41
FWCI: 10.34
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 44866, MH38546, P50MH044866)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine D1 receptor, prefrontal cortex, working memory, memory-guided saccades, oculomotor tasks, SCH 23390, delay period, rhesus monkeys, memory function
MeSH terms: Animals, Benzazepines, Cerebral Cortex, Macaca mulatta, Memory, Receptors, Dopamine, Salicylamides, Visual Perception, Receptors, Dopamine D1, Dopamine Antagonists, Raclopride

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D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory

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