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D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Abstract
The prefrontal cortex is involved in the cognitive process of working memory. Local injections of SCH23390 and SCH39166, selective antagonists of the D1 dopamine receptor, into the prefrontal cortex of rhesus monkeys induced errors and increased latency in performance on an oculomotor task that required memory-guided saccades. The deficit was dose-dependent and sensitive to the duration of the delay period. These D1 antagonists had no effect on performance in a control task requiring visually guided saccades, indicating that sensory and motor functions were unaltered. Thus, D1 dopamine receptors play a selective role in the mnemonic, predictive functions of the primate prefrontal cortex.
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In the citing paper
“evidence from non‐human primates (Sawaguchi & Goldman‐Rakic, 1991, 1994; Williams & Goldmanrakic, 1995) and in healthy humans (Fischer et al., 2010) showed that dopamine depletion or antagonism impairs visuospatial WM.”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Sawaguchi & Goldman‐Rakic, 1991
In the citing paper
“Both blockade and excessive stimulation of D1 receptors impair spatial working memory65–67.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [66]
In the citing paper
“Cognitive studies in animals have shown that either blockade of D1/5 receptors or excessive stimulation of D1/5 receptors in the PFC impairs spatial working memory (106–108).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [107]
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Metadata
- Authors
- Sawaguchi, T., & Goldman-Rakic, P. S.
- Affiliations
- Yale University (US)
- Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.
- Venue
- Science
- Published
- 1991-02-22
- Volume
- 251
- Issue
- 4996
- Pages
- 947-950
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058396154
- Cited by
- 1,364
- References
- 24
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 24 · 2023: 22 · 2022: 31 · 2021: 30 · 2020: 28 · 2019: 31 · 2018: 33 · 2017: 27 · 2016: 40 · 2015: 54 · 2014: 53 · 2013: 34 · 2012: 41
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 44866, MH38546, P50MH044866)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine D1 receptor, prefrontal cortex, working memory, memory-guided saccades, oculomotor tasks, SCH 23390, delay period, rhesus monkeys, memory function
- MeSH terms
- Animals, Benzazepines, Cerebral Cortex, Macaca mulatta, Memory, Receptors, Dopamine, Salicylamides, Visual Perception, Receptors, Dopamine D1, Dopamine Antagonists, Raclopride
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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