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Ethane Evolution: A New Index of Lipid Peroxidation
Abstract
Homogenates of mouse liver and brain at 37°C spontaneously formed lipid peroxides and simultaneously evolved ethane. α-Tocopherol, a lipid antioxidant, blocked ethane formation. When mice were injected with carbon tetrachloride (a liquid prooxidant for liver), the animals produced ethane. Ethane evolution in vivo was stimulated by prior administration of phenobarbital and it was diminished by prior injection of α-tocopherol. These data suggest that ethane production may be a useful index of lipid peroxidation in tissue homogenates and in intact animals.
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Cited by
Amann, A., Costello, B. D. L., Miekisch, W., Schubert, J., Buszewski, B., Pleil, J., Ratcliffe, N., & Risby, T. (2014) · Journal of Breath Research · doi:10.1088/1752-7155/8/3/034001 · Cited by 804
Oxygen Activation and Oxygen Toxicity
Elstner, E. F. (1982) · Annual Review of Plant Physiology · doi:10.1146/annurev.pp.33.060182.000445 · Cited by 710
Basu, S. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00157-4 · Cited by 396
Lipid Peroxidation and Mechanisms of Toxicity
Horton, A. A., Fairhurst, S., & Bus, J. S. (1987) · CRC Critical Reviews in Toxicology · doi:10.3109/10408448709089856 · Cited by 339
Breathomics for the clinician: the use of volatile organic compounds in respiratory diseases
Ibrahim, W., Carr, L., Cordell, R., Wilde, M. J., Salman, D., Monks, P. S., Thomas, P., Brightling, C. E., Siddiqui, S., & Greening, N. J. (2021) · Thorax · doi:10.1136/thoraxjnl-2020-215667 · Cited by 115
Metadata
- Authors
- Riely, C. A., Cohen, G., & Lieberman, M.
- Venue
- Science
- Published
- 1974-01-18
- Volume
- 183
- Issue
- 4121
- Pages
- 208-210
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994635899
- Cited by
- 449
- References
- 0
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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