The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulation of the Apolipoprotein AI Gene by ARP-1, a Novel Member of the Steroid Receptor Superfamily
Abstract
Apolipoprotein AI (apoAI) is a lipid-binding protein that participates in the transport of cholesterol and other lipids in the plasma. A complementary DNA clone for a protein that bound to regulatory elements of the apoAI gene was isolated. This protein, designated apoAI regulatory protein-1 (ARP-1), is a novel member of the steroid hormone receptor superfamily. ARP-1 bound to DNA as a dimer, and its dimerization domain was localized to the COOH-terminal region. ARP-1 also bound to a thyroid hormone-responsive element and to regulatory regions of the apoB, apoCIII, insulin, and ovalbumin genes. In cotransfection experiments, ARP-1 downregulated the apoAI gene. The involvement of ARP-1 in the regulation of apoAI gene expression suggests that it may participate in lipid metabolism and cholesterol homeostasis.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Gene regulation by steroid hormones
Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383
Cited by
Zanaria, E., Muscatelli, F., Bardoni, B., Strom, T. M., Guioli, S., Guo, W., Lalli, E., Moser, C., Walker, A. P., McCabe, E. R. B., et al. (1994) · Nature · doi:10.1038/372635a0 · Cited by 858
Li, P.-X., Wong, J., Ayed, A., Ngo, D., Brade, A. M., Arrowsmith, C., Austin, R. C., & Klamut, H. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909580199 · Cited by 254
Blanchard, K. L., Acquaviva, A. M., Galson, D. L., & Bunn, H. F. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5373 · Cited by 215
Zeitoun, K., Takayama, K., Michael, M. D., & Bulun, S. E. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.2.0229 · Cited by 216
Structure and Function of the Estrogen Receptor
PARKER, M. G., ARBUCKLE, N., DAUVOIS, S., DANIELIAN, P., & WHITE, R. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb32276.x · Cited by 129
Metadata
- Authors
- Ladias, J. A. A., & Karathanasis, S. K.
- Venue
- Science
- Published
- 1991-02
- Volume
- 251
- Issue
- 4993
- Pages
- 561-565
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069968362
- Cited by
- 377
- References
- 2
- FWCI
- 54.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ladias, J. A. A., & Karathanasis, S. K. (1991). Regulation of the Apolipoprotein AI Gene by ARP-1, a Novel Member of the Steroid Receptor Superfamily. Science. https://doi.org/10.1126/science.1899293
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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