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Atomic Force Microscopy and Dissection of Gap Junctions
Abstract
An atomic force microscope (AFM) was used to study the structure of isolated hepatic gap junctions in phosphate-buffered saline (PBS). The thickness of these gap junctions appears to be 14.4 nanometers, close to the dimensions reported by electron microscopy (EM). When an increasing force is applied to the microscope tip, the top membrane of the gap junction can be "dissected" away, leaving the extracellular domains of the bottom membrane exposed. When such "force dissection" is performed on samples both trypsinized and fixed with glutaraldehyde, the hexagonal array of gap junction hemichannels is revealed, with a center-to-center spacing of 9.1 nanometers.
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Cited by
Reproducible Imaging and Dissection of Plasmid DNA Under Liquid with the Atomic Force Microscope
Hansma, H. G., Vesenka, J., Siegerist, C., Kelderman, G., Morrett, H., Sinsheimer, R. L., Elings, V., Bustamante, C., & Hansma, P. K. (1992) · Science · doi:10.1126/science.256.5060.1180 · Cited by 517
AFM: a versatile tool in biophysics
Alessandrini, A., & Facci, P. (2005) · Measurement Science and Technology · doi:10.1088/0957-0233/16/6/r01 · Cited by 384
Human cornea and sclera studied by atomic force microscopy
Meller, D., Meller, K., & Peters, K. (1997) · Cell and Tissue Research · doi:10.1007/s004410050798 · Cited by 88
Metadata
- Authors
- Hoh, J. H., Lal, R., John, S. A., Revel, J.-P., & Arnsdorf, M. F.
- Venue
- Science
- Published
- 1991-09-20
- Volume
- 253
- Issue
- 5026
- Pages
- 1405-1408
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995685967
- Cited by
- 245
- References
- 0
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Atomic Force Microscopy and Dissection of Gap Junctions. https://app.cochat.ai/papers/10.1126/science.1910206
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- Hoh, J. H., Lal, R., John, S. A., Revel, J.-P., & Arnsdorf, M. F. (1991). Atomic Force Microscopy and Dissection of Gap Junctions. Science. https://doi.org/10.1126/science.1910206
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
